scholarly journals Atorvastatin Inhibits Myocardial Cell Apoptosis in a Rat Model with Post-myocardial Infarction Heart Failure by Downregulating ER Stress Response

2011 ◽  
Vol 8 (7) ◽  
pp. 564-572 ◽  
Author(s):  
Xian Jing Song ◽  
Chun Yan Yang ◽  
Bin Liu ◽  
Qun Wei ◽  
Melvin T. Korkor ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Stress Response ◽  
Er Stress ◽  
Rat Model ◽  
Cell Apoptosis ◽  
Myocardial Cell ◽  
Post Myocardial Infarction ◽  
Er Stress Response ◽  
Infarction Heart

scholarly journals Yiqi Huoxue Recipe Improves Heart Function through Inhibiting Apoptosis Related to Endoplasmic Reticulum Stress in Myocardial Infarction Model of Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Li-Xia Lou ◽  
Ai-Ming Wu ◽  
Dong-Mei Zhang ◽  
Sheng-Xian Wu ◽  
Yong-Hong Gao ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Endoplasmic Reticulum ◽  
Stress Response ◽  
Er Stress ◽  
Heart Function ◽  
Tunel Staining ◽  
Sham Operation ◽  
Er Stress Response ◽  
Stress Response Pathway

Objective. To explore the mechanism of cardioprotective effects of Chinese medicine, Yiqi Huoxue recipe, in rats with myocardial infarction- (MI-) induced heart failure.Methods. Male Sprague-Dawley rats underwent left anterior descending artery (LAD) ligation or sham operation. The surviving MI rats were divided randomly into three groups: MI (5 mL/kg/d NS by gavage), MI + Metoprolol Tartrate (MT) (12 mg/kg/d MT by gavage), and MI + Yiqi Huoxue (5 mL/kg recipe by gavage). And the sham operation rats were given 5 mL/kg/d normal saline. Treatments were given on the day following surgery for 4 weeks. Then rats were detected for heart structure and function by transthoracic echocardiography. Apoptosis in heart tissues was detected by TUNEL staining. To determine whether the endoplasmic reticulum (ER) stress response pathway is included in the cardioprotective function of the recipe, ER stress related proteins such as GRP78 and caspase-12 were examined.Results. Yiqi Huoxue recipe attenuated heart function injury, reversed histopathological damage, alleviated myocardial apoptosis and inhibited ER stress in MI rats.Conclusion. All the results suggest that Yiqi Huoxue recipe improves the injured heart function maybe through inhibition of ER stress response pathway, which is a promising target in therapy for heart failure.

Abstract 257: Endogenous Activating Transcription Factor 6 Preserves Heart Structure and Function in a Mouse Model of Myocardial Infarction-induced Heart Failure

2017 ◽  
Vol 121 (suppl_1) ◽  
Author(s):  
Winston T Stauffer ◽  
Khalid Azizi ◽  
Erik A Blackwood ◽  
Randal J Kaufman ◽  
Christopher C Glembotski
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Transcription Factor ◽  
Stress Response ◽  
Er Stress ◽  
Heart Function ◽  
Structure And Function ◽  
Er Stress Response ◽  
Activating Transcription Factor ◽  
And Function

Rationale: The ER stress response is activated by the accumulation of misfolded, toxic proteins in the endoplasmic reticulum (ER), and upregulates proteins that restore ER protein-folding capacity. The ER-transmembrane protein, activating transcription factor 6 (ATF6) senses ER stress and responds by transcriptionally inducing many of these genes and is thus a key component of the adaptive ER stress response. We previously showed that in the heart, ischemia activates ATF6. Furthermore, transgenic mouse hearts expressing a conditionally activated form of ATF6, and subjected to ex vivo ischemia/reperfusion, exhibited preserved heart function and smaller infarcts. Our lab also showed that by serving as a novel inducer of a global anti-oxidant gene program, endogenous ATF6 limits cardiac damage caused by reactive oxygen species during reperfusion. However, the effect of endogenous ATF6 in the failing heart is not known. Given that acute ischemia caused by occlusion of the coronary arteries is the cause of myocardial infarction (MI), we hypothesized that endogenous ATF6 limits infarct size and preserves heart function during MI. Additionally, since deleterious cardiac remodeling and heart failure can be long-term consequences of MI, we hypothesized that ATF6 can mitigate these effects. Objective/Methods: To examine the role of endogenous ATF6 in heart failure, in vivo, we used a mouse model of MI-induced heart failure in mice with a global deletion of the ATF6 gene (ATF6 KO). Infarct size was measured by TTC staining and heart function was observed via longitudinal echocardiogram. Results: We found that following infarction, ATF6 KO mouse hearts had larger infarcts compared to control. Thus, ischemic cardiac tissue in the peri-infarct region requires ATF6 to limit cardiac myocyte death. Interestingly, ejection fraction following MI decreased more over 13 weeks in ATF6 KO mice relative to control. While control and ATF6 KO mouse hearts hypertrophied to a similar degree, KO mice showed greater cardiac dilation. Conclusions: Together these findings show for the first time that endogenous ATF6 acts to preserve heart structure and function in an MI model of heart failure, suggesting that ATF6 may be a viable therapeutic target for treatment of this disease.

scholarly journals Early and late effects of the DPP-4 inhibitor vildagliptin in a rat model of post-myocardial infarction heart failure

2011 ◽  
Vol 10 (1) ◽  
pp. 85 ◽  
Author(s):  
Meimei Yin ◽  
Herman HW Silljé ◽  
Maxi Meissner ◽  
Wiek H van Gilst ◽  
Rudolf A de Boer
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Rat Model ◽  
Late Effects ◽  
Post Myocardial Infarction ◽  
Infarction Heart

Levosimendan improves contractilityin vivoandin vitroin a rodent model of post-myocardial infarction heart failure

2014 ◽  
Vol 210 (4) ◽  
pp. 865-874 ◽  
Author(s):  
S. M. Kolseth ◽  
N. P. L. Rolim ◽  
Ø. Salvesen ◽  
D. O. Nordhaug ◽  
A. Wahba ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Rodent Model ◽  
Post Myocardial Infarction ◽  
Infarction Heart

scholarly journals Mitochondrial cyclophilin-D as a potential therapeutic target for post-myocardial infarction heart failure

2011 ◽  
Vol 15 (11) ◽  
pp. 2443-2451 ◽  
Author(s):  
Shiang Y. Lim ◽  
Derek J. Hausenloy ◽  
Sapna Arjun ◽  
Anthony N. Price ◽  
Sean M. Davidson ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Therapeutic Target ◽  
Post Myocardial Infarction ◽  
Cyclophilin D ◽  
Potential Therapeutic Target ◽  
Infarction Heart

Regenerative Approaches to Post-Myocardial Infarction Heart Failure

2014 ◽  
Vol 20 (12) ◽  
pp. 1930-1940 ◽  
Author(s):  
Kenneth Martin ◽  
Chien-Ling Huang ◽  
Noel Caplice
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Post Myocardial Infarction ◽  
Infarction Heart
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