scholarly journals Genetic Polymorphisms of Matrix Metalloproteinases and Clinical Outcomes in Colorectal Cancer Patients

2013 ◽  
Vol 10 (8) ◽  
pp. 1022-1027 ◽  
Author(s):  
Wen-Chien Ting ◽  
Lu-Min Chen ◽  
Jiunn-Bey Pao ◽  
Ying-Pi Yang ◽  
Bang-Jau You ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Matrix Metalloproteinases ◽  
Cancer Patients ◽  
Clinical Outcomes ◽  
Genetic Polymorphisms ◽  
Colorectal Cancer Patients

scholarly journals Correlation between tumor engraftment in patient-derived xenograft models and clinical outcomes in colorectal cancer patients

Oncotarget ◽  
2015 ◽  
Vol 6 (18) ◽  
pp. 16059-16068 ◽  
Author(s):  
Bo Young Oh ◽  
Woo Yong Lee ◽  
Sungwon Jung ◽  
Hye Kyung Hong ◽  
Do-Hyun Nam ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Clinical Outcomes ◽  
Patient Derived Xenograft ◽  
Xenograft Models ◽  
Colorectal Cancer Patients

scholarly journals MO1-2 Geriatric assessment and clinical outcomes for elderly colorectal cancer patients

2021 ◽  
Vol 32 ◽  
pp. S294
Author(s):  
Ayako Doi ◽  
Hiroyuki Takeda ◽  
Kumiko Umemoto ◽  
Hiroyuki Arai ◽  
Yoshiki Horie ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Clinical Outcomes ◽  
Geriatric Assessment ◽  
Colorectal Cancer Patients

scholarly journals Associations between oncogenic risk markers and clinical outcomes among black and white colorectal cancer patients.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e16078-e16078
Author(s):  
Victoria Starks ◽  
Edith P. Mitchell
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Clinical Outcomes ◽  
Disease Free Survival ◽  
Risk Markers ◽  
Braf Mutations ◽  
Black And White ◽  
Response To Chemotherapy ◽  
Incidence And Mortality ◽  
Colorectal Cancer Patients

e16078 Background: Blacks have a 25% higher incidence of colorectal cancer compared to their white societal counterparts1. Additionally, the overall mortality rate among black colorectal cancer patients is 50% higher than that of whites2. However, little is known about the biomarkers prevalent among blacks and their possible correlation to treatment response and patient outcomes. Objective: The objective of this study is to explore disease trends that may unveil a correlation between molecular markers, pathologic stage at presentation and poor clinical outcomes among black colorectal cancer patients. Methods: De-identified patient data was obtained from The Oncology Data Services Department (Cancer Registry) of TJUH. The population cohort (n = 836) included newly diagnosed colorectal cancer patients treated at TJUH from 2000-2019, & included information regarding patient race, sex, age at presentation, stage at presentation, histological code, tumor markers: KRAS, NRAS, BRAF, MS1, treatment received, surgical findings: tumor size, lymph node involvement, presence of distant metastases at first surgery, response to chemotherapy & disease-free survival. Results: Findings reveal a higher prevalence of BRAF mutations among whites compared to blacks within this population, while black patients were diagnosed later according to AJCC pathological stage at presentation. Future analysis of this cohort will further divide the population by age ( < 50, 50-65, & > 65). This facet of the study will explore relationships between age & stage at presentation among patients of different races. Conclusions: Both oncogenic risk markers and AJCC stage at presentation differ between black and white colorectal cancer patients within this population. Additional analysis regarding age at presentation will further inform us as to how these findings may contribute to the comparatively higher incidence and mortality rates among black colorectal cancer patients. Researchers should continue to explore possible etiologies for the prevalent racial disparities seen among black colorectal cancer patients.

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