scholarly journals Comparison of a Two-Lead, Computerized, Resting ECG Signal Analysis Device, the MultiFunction-CardioGramsm or MCG (a.k.a. 3DMP), to Quantitative Coronary Angiography for the Detection of Relevant Coronary Artery Stenosis (>70%) - A Meta-Analysis of all Published Trials Performed and Analyzed in the US

2009 ◽  
pp. 143-155 ◽  
Author(s):  
John E. Strobeck ◽  
Joseph T. Shen ◽  
Binoy Singh ◽  
Kotaro Obunai ◽  
Charles Miceli ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Angiography ◽  
Signal Analysis ◽  
Coronary Artery Stenosis ◽  
Meta Analysis ◽  
Quantitative Coronary Angiography ◽  
Artery Stenosis ◽  
Ecg Signal ◽  
The Us

scholarly journals Influence of Coronary Artery Stenosis Severity and Coronary Collateralization on Extent of Chronic Myocardial Scar: Insights from Quantitative Coronary Angiography and Delayed-Enhancement MRI

2008 ◽  
Vol 2 (1) ◽  
pp. 79-86 ◽  
Author(s):  
Daniel Bexell ◽  
Randolph M Setser ◽  
Paul Schoenhagen ◽  
Michael L Lieber ◽  
Sorin J Brener ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Angiography ◽  
Coronary Artery Stenosis ◽  
Quantitative Coronary Angiography ◽  
Myocardial Scar ◽  
Delayed Enhancement ◽  
Artery Stenosis ◽  
Significant Stenosis ◽  
Stenosis Severity ◽  
The Relationship

Objectives:In patients with chronic ischemic heart disease, the relationship between coronary artery lesion severity and myocardial scarring is unknown.The purpose of this study was to examine the relationship between proximal coronary artery stenosis severity, the amount of coronary collateralization, and myocardial scar extent in the distal distribution of the affected coronary artery based on both quantitative coronary angiography (QCA) and delayed-enhancement magnetic resonance imaging (DE–MRI).Methods:Thirty-four patients (26 males, 8 females; age range: 35-86 years) with a coronary artery containing a single, proximal stenosis ≥30% by quantitative coronary angiography (QCA) underwent DE-MRI. The relationship between stenosis severity, collateralization, and myocardial scar morphology (area, transmurality and patchiness) was examined using linear mixed-model ANCOVA.Results:There was a statistically significant correlation between stenosis severity and scar extent (r=0.53, p<0.01). Patients with hemodynamically significant stenoses (≥70%) exhibited significantly greater collateralization (p<0.05) and scar extent (p<0.01) than patients with <70% stenosis. However, scarring was often found in patients with stenoses <70%. Also, greater stenosis severity (93±14%) and mean scar extent (41±35%) were found in patients with collaterals than in patients without collaterals (diameter stenosis 48±10%, p<0.01) (scar extent 19±29%, p=0.01).Conclusions:Using QCA and DE-MRI, we demonstrate a significant relationship between coronary artery stenosis severity and myocardial scar extent, in the absence of a documented history of acute infarction. The relationship likely reflects increasing ischemia leading to scar formation in the range of angiographically significant stenosis. However, in the absence of collateralization, scar was observed without significant stenosis, especially in females.

Sign in / Sign up

Export Citation Format

Share Document