scholarly journals The Anti-Fibrotic Effect of Bone Morphogenic Protein-7(BMP-7) on Liver Fibrosis

2013 ◽  
Vol 10 (4) ◽  
pp. 441-450 ◽  
Author(s):  
Lan Zhong ◽  
Xiaolin Wang ◽  
Shenglan Wang ◽  
Li Yang ◽  
Hengjun Gao ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Bone Morphogenic Protein ◽  
Bone Morphogenic Protein 7

scholarly journals Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7

2014 ◽  
Vol 15 (1) ◽  
pp. 38 ◽  
Author(s):  
Ann-Marie Heinonen ◽  
Mahbubur Rahman ◽  
Godwin Dogbevia ◽  
Hannah Jakobi ◽  
Stefan Wölfl ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Bone Morphogenic Protein ◽  
Bone Morphogenic Protein 7

Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models

2003 ◽  
Vol 285 (6) ◽  
pp. F1060-F1067 ◽  
Author(s):  
Michael Zeisberg ◽  
Cindy Bottiglio ◽  
Navin Kumar ◽  
Yohei Maeshima ◽  
Frank Strutz ◽  
...  
Keyword(s):  
Mouse Models ◽  
Renal Injury ◽  
Renal Fibrosis ◽  
Type I Collagen ◽  
Chronic Renal Disease ◽  
Bone Morphogenic Protein ◽  
Matrix Metalloproteinase 2 ◽  
Type I ◽  
Protective Function ◽  
Bone Morphogenic Protein 7

Tubulointerstitial fibrosis is a hallmark feature of chronic renal injury. Specific therapies to control the progression of renal fibrosis toward end-stage renal failure are limited. Previous studies have demonstrated that expression of endogenous bone morphogenic protein-7 (BMP-7) is reduced in the kidneys of several inducible mouse models of acute and chronic renal disease and that administration of exogenous recombinant human BMP-7 (rhBMP-7) has a beneficial effect on kidney function. Here we report that treatment with rhBMP-7 leads to improved renal function, histology, and survival in mice deficient in the α3-chain of type IV collagen and MRL/MpJ lpr/lpr lupus mice, two genetic models for chronic renal injury and fibrosis. Such therapeutic benefit is also associated with a significant decrease in the expression of profibrotic molecules, such as type I collagen and fibronectin, in renal fibroblasts. Additionally, rhBMP-7 induces expression of active matrix metalloproteinase-2, which is potentially important for removal of fibrotic matrix. Collectively, these studies provide further evidence for rhBMP-7 as an important bone-associated protein with protective function against renal pathology.

Abstract 4059: The bone morphogenic protein 7 (Bmp7) plays a pro-tumorigenic role in pheochromocytoma

2014 ◽  
Author(s):  
Ines Leinhäuser ◽  
Ines Höfig ◽  
Natasa Anastasov ◽  
Felix Beuschlein ◽  
Massimo Mannelli ◽  
...  
Keyword(s):  
Bone Morphogenic Protein ◽  
Bone Morphogenic Protein 7

scholarly journals Dual Network Hydrogels Incorporated with Bone Morphogenic Protein-7-Loaded Hyaluronic Acid Complex Nanoparticles for Inducing Chondrogenic Differentiation of Synovium-Derived Mesenchymal Stem Cells

Pharmaceutics ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 613
Author(s):  
Qing Min ◽  
Jiaoyan Liu ◽  
Yuchen Zhang ◽  
Bin Yang ◽  
Ying Wan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Hyaluronic Acid ◽  
Chondrogenic Differentiation ◽  
Sol Gel ◽  
Bone Morphogenic Protein ◽  
Cartilage Tissue ◽  
Acid Complex ◽  
Composite Gels ◽  
Bone Morphogenic Protein 7

Alginate-poloxamer (ALG-POL) copolymer with optimal POL content was synthesized, and it was combined with silk fibroin (SF) for building ALG-POL/SF dual network hydrogels. Hyaluronic acid(HA)/chitosan-poly(dioxanone)(CH-PDO) complex nanoparticles (NPs) with optimized composition and high encapsulation efficiency were employed as a vehicle for loading bone morphogenic protein-7 (BMP-7). BMP-7-loaded HA/CH-PDO NPs were incorporated into ALG-POL/SF hydrogel for constructing composite gels to achieve controlled release of BMP-7. These gels showed thermosensitive sol-gel transitions near physiological temperature and pH; and they were tested to be elastic, tough and strong. Some gels exhibited abilities to administer the BMP-7 release in nearly linear manners for a few weeks. Synovium-derived mesenchymal stem cells (SMSCs) were seeded into optimally fabricated gels for assessing their chondrogenic differentiation potency. Real-time PCR analyses showed that the blank ALG-POL/SF gels were not able to induce the chondrogenic differentiation of SMSCs, whereas SMSCs were detected to significantly express cartilage-related genes once they were seeded in the BMP-7-loaded ALG-POL/SF gel for two weeks. The synthesis of cartilaginous matrix components further confirmed that SMSCs seeded in the BMP-7-loaded ALG-POL/SF gel differentiated toward chondrogenesis. Results suggest that BMP-7-loaded ALG-POL/SF composite gels can function as a promising biomaterial for cartilage tissue engineering applications.

scholarly journals Use of Bone Morphogenic Protein-7 as a Treatment for Osteoarthritis

2008 ◽  
Vol 467 (12) ◽  
pp. 3221-3229 ◽  
Author(s):  
Neil Badlani ◽  
Yasushi Oshima ◽  
Rob Healey ◽  
Richard Coutts ◽  
David Amiel
Keyword(s):  
Bone Morphogenic Protein ◽  
Bone Morphogenic Protein 7
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