scholarly journals Inflammatory Stress Exacerbates the Progression of Cardiac Fibrosis in High-Fat-Fed Apolipoprotein E Knockout Mice via Endothelial-Mesenchymal Transition

2013 ◽  
Vol 10 (4) ◽  
pp. 420-426 ◽  
Author(s):  
Kun Ling Ma ◽  
Jing Liu ◽  
Jie Ni ◽  
Yang Zhang ◽  
Lin Li Lv ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Knockout Mice ◽  
Cardiac Fibrosis ◽  
High Fat ◽  
Inflammatory Stress ◽  
Mesenchymal Transition ◽  
Apolipoprotein E Knockout Mice ◽  
Endothelial Mesenchymal Transition

Effect of Saffron on Metabolic Profile and Retina in Apolipoprotein E–Knockout Mice Fed a High-Fat Diet

2017 ◽  
Vol 15 (4) ◽  
pp. 471-481 ◽  
Author(s):  
Evangelos K. Doumouchtsis ◽  
Aspasia Tzani ◽  
Ilias P. Doulamis ◽  
Panagiotis Konstantopoulos ◽  
Korou Laskarina-Maria ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Knockout Mice ◽  
High Fat Diet ◽  
Metabolic Profile ◽  
High Fat ◽  
Apolipoprotein E Knockout Mice

scholarly journals Apolipoprotein E-knockout mice on high-fat diet show autoimmune injury on kidney and aorta

2014 ◽  
Vol 450 (1) ◽  
pp. 788-793 ◽  
Author(s):  
Yuehai Wang ◽  
Huixia Lu ◽  
Ziyang Huang ◽  
Huili Lin ◽  
Zhenmin Lei ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Knockout Mice ◽  
High Fat Diet ◽  
High Fat ◽  
Apolipoprotein E Knockout Mice

scholarly journals MicroRNA-126 inhibits endothelial permeability and apoptosis in apolipoprotein E-knockout mice fed a high-fat diet

2017 ◽  
Vol 16 (3) ◽  
pp. 3061-3068 ◽  
Author(s):  
Xiao-Wen Cheng ◽  
Yu-Feng Wan ◽  
Qing Zhou ◽  
Yuan Wang ◽  
Hua-Qing Zhu
Keyword(s):  
Apolipoprotein E ◽  
Knockout Mice ◽  
High Fat Diet ◽  
Endothelial Permeability ◽  
High Fat ◽  
Apolipoprotein E Knockout Mice

scholarly journals Angiotensin Receptor Blocker and Neprilysin Inhibitor Suppresses Cardiac Dysfunction by Accelerating Myocardial Angiogenesis in Apolipoprotein E-Knockout Mice Fed a High-Fat Diet

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Yasunori Suematsu ◽  
Kohei Tashiro ◽  
Hidetaka Morita ◽  
Akihito Ideishi ◽  
Takashi Kuwano ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Natriuretic Peptide ◽  
Knockout Mice ◽  
Cardiac Dysfunction ◽  
High Fat Diet ◽  
Angiotensin Receptor Blocker ◽  
Left Ventricular ◽  
Angiotensin Receptor ◽  
High Fat ◽  
Apolipoprotein E Knockout Mice

Hypothesis. Myocardial angiogenesis is important for maintaining cardiac contractile function in patients with cardiac hypertrophy. Evidence shows that angiotensin receptor blocker and neprilysin inhibitors (ARNIs) improve heart failure. The present study investigated the myocardial angiogenic effect of valsartan plus sacubitril in early-stage cardiac dysfunction. Materials and Methods. Male apolipoprotein E-knockout mice fed a high-fat diet were divided into control (CTL), valsartan (30 mg/kg) (VAL), sacubitril (30 mg/kg) (SAC), and valsartan plus sacubitril (30 mg/kg each) (VAL/SAC) groups after 4 weeks of prefeeding and were subsequently treated for 12 weeks. Results. The VAL/SAC group exhibited significantly higher serum brain natriuretic peptide levels; more subtle changes in left ventricular systolic diameter, fractional shortening, and ejection fraction, and significantly higher expression levels of natriuretic peptide precursor B and markers of angiogenesis, including clusters of differentiation 34, vascular endothelial growth factor A, and monocyte chemotactic protein 1, than the CTL group. Conclusions. Valsartan plus sacubitril preserved left ventricular systolic function in apolipoprotein E-knockout mice fed a high-fat diet. This result suggests that myocardial angiogenic factors induced by ARNI might provide cardioprotective effects.

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