scholarly journals Adipocytes and macrophages secretomes coregulate catecholamine-synthesizing enzymes

2021 ◽  
Vol 18 (3) ◽  
pp. 582-592
Author(s):  
Andreia Gomes ◽  
Fernanda Leite ◽  
Laura Ribeiro
Keyword(s):  
Catecholamine Synthesizing Enzymes

scholarly journals Effects of Insulin Treatment without and with Recurrent Hypoglycemia on Hypoglycemic Counterregulation and Adrenal Catecholamine-Synthesizing Enzymes in Diabetic Rats

Endocrinology ◽  
2006 ◽  
Vol 147 (4) ◽  
pp. 1860-1870 ◽  
Author(s):  
Karen E. Inouye ◽  
Jessica T. Y. Yue ◽  
Owen Chan ◽  
Tony Kim ◽  
Eitan M. Akirav ◽  
...  
Keyword(s):  
Tyrosine Hydroxylase ◽  
Insulin Treatment ◽  
Diabetic Rats ◽  
Hyperinsulinemic Hypoglycemia ◽  
Mrna Levels ◽  
Relevant Model ◽  
Counterregulatory Hormones ◽  
Catecholamine Synthesizing Enzymes ◽  
Recurrent Hypoglycemia ◽  
Th Mrna

Untreated diabetic rats show impaired counterregulation against hypoglycemia. The blunted epinephrine responses are associated with reduced adrenomedullary tyrosine hydroxylase (TH) mRNA levels. Recurrent hypoglycemia further impairs epinephrine counterregulation and is also associated with reduced phenylethanolamine N-methyltransferase mRNA. This study investigated the adaptations underlying impaired counterregulation in insulin-treated diabetic rats, a more clinically relevant model. We studied the effects of insulin treatment on counterregulatory hormones and adrenal catecholamine-synthesizing enzymes and adaptations after recurrent hypoglycemia. Groups included: normal; diabetic, insulin-treated for 3 wk (DI); and insulin-treated diabetic exposed to seven episodes (over 4 d) of hyperinsulinemic-hypoglycemia (DI-hypo) or hyperinsulinemic-hyperglycemia (DI-hyper). DI-hyper rats differentiated the effects of hyperinsulinemia from those of hypoglycemia. On d 5, rats from all groups were assessed for adrenal catecholamine-synthesizing enzyme levels or underwent hypoglycemic clamps to examine counterregulatory responses. Despite insulin treatment, fasting corticosterone levels remained increased, and corticosterone responses to hypoglycemia were impaired in DI rats. However, glucagon, epinephrine, norepinephrine, and ACTH counterregulatory defects were prevented. Recurrent hypoglycemia in DI-hypo rats blunted corticosterone but, surprisingly, not epinephrine responses. Norepinephrine and ACTH responses also were not impaired, whereas glucagon counterregulation was reduced due to repeated hyperinsulinemia. Insulin treatment prevented decreases in basal TH protein and increased PNMT and dopamine β-hydroxylase protein. DI-hypo rats showed increases in TH, PNMT, and dopamine β-hydroxylase. We conclude that insulin treatment of diabetic rats protects against most counterregulatory defects but not elevated fasting corticosterone and decreased corticosterone counterregulation. Protection against epinephrine defects, both without and with antecedent hypoglycemia, is associated with enhancement of adrenal catecholamine-synthesizing enzyme levels.

Genes of human catecholamine-synthesizing enzymes

1991 ◽  
pp. 19-38
Author(s):  
T. Nagatsu ◽  
N. Kaneda ◽  
K. Kobayashi ◽  
H. Ichinose ◽  
T. Sasaoka ◽  
...  
Keyword(s):  
Catecholamine Synthesizing Enzymes

scholarly journals Immunohistocytochemical localization of catecholamine-synthesizing enzymes in suprarenal, superior cervical and nodose ganglia of dogs.

1981 ◽  
Vol 14 (6) ◽  
pp. 588-595 ◽  
Author(s):  
MASAMI YOSHIDA ◽  
YUKARI KONDO ◽  
NOBUYUKI KARASAWA ◽  
KEIKI YAMADA ◽  
ISAMU TAKAGI ◽  
...  
Keyword(s):  
Nodose Ganglia ◽  
Catecholamine Synthesizing Enzymes
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