scholarly journals Interaction between Polymorphisms of DNA Repair Genes Significantly Modulated Bladder Cancer Risk

2012 ◽  
Vol 9 (6) ◽  
pp. 498-505 ◽  
Author(s):  
Yi Zhi ◽  
Jing Yu ◽  
Yang Liu ◽  
Quanfang Wei ◽  
Fang Yuan ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Dna Repair Genes ◽  
Bladder Cancer Risk ◽  
Repair Genes

scholarly journals Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk

2009 ◽  
Vol 30 (5) ◽  
pp. 763-768 ◽  
Author(s):  
Stefan Michiels ◽  
Agnès Laplanche ◽  
Thomas Boulet ◽  
Philippe Dessen ◽  
Bertrand Guillonneau ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Dna Repair Genes ◽  
Bladder Cancer Risk ◽  
Repair Genes

scholarly journals Polymorphisms in DNA Repair Genes, Smoking, and Bladder Cancer Risk: Findings from the International Consortium of Bladder Cancer

2009 ◽  
Vol 69 (17) ◽  
pp. 6857-6864 ◽  
Author(s):  
Mariana C. Stern ◽  
Jie Lin ◽  
Jonine D. Figueroa ◽  
Karl T. Kelsey ◽  
Anne E. Kiltie ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Dna Repair Genes ◽  
Bladder Cancer Risk ◽  
International Consortium ◽  
Repair Genes

Germline mutations in DNA repair genes are associated with bladder cancer risk and unfavourable prognosis

2018 ◽  
Vol 122 (5) ◽  
pp. 808-813 ◽  
Author(s):  
Rong Na ◽  
Yishuo Wu ◽  
Guangliang Jiang ◽  
Hongjie Yu ◽  
Xiaoling Lin ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Germline Mutations ◽  
Dna Repair Genes ◽  
Bladder Cancer Risk ◽  
Unfavourable Prognosis ◽  
Repair Genes

scholarly journals The Cellular Response to Oxidatively Induced DNA Damage and Polymorphism of Some DNA Repair Genes Associated with Clinicopathological Features of Bladder Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Nataliya V. Savina ◽  
Nataliya V. Nikitchenko ◽  
Tatyana D. Kuzhir ◽  
Alexander I. Rolevich ◽  
Sergei A. Krasny ◽  
...  
Keyword(s):  
Dna Damage ◽  
Bladder Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Excision Repair ◽  
Clinicopathological Features ◽  
Low Grade ◽  
Dna Repair Genes ◽  
Muscle Invasive ◽  
Repair Genes

Genome instability and impaired DNA repair are hallmarks of carcinogenesis. The study was aimed at evaluating the DNA damage response in H2O2-treated lymphocytes using the alkaline comet assay in bladder cancer (BC) patients as compared to clinically healthy controls, elderly persons, and individuals with chronic inflammations. Polymorphism in DNA repair genes involved in nucleotide excision repair (NER) and base excision repair (BER) was studied using the PCR-RFLP method in the Belarusian population to elucidate the possible association of their variations with both bladder cancer risk and clinicopathological features of tumors. The increased level of H2O2-induced DNA damage and a higher proportion of individuals sensitive to oxidative stress were found among BC patients as compared to other groups under study. Heterozygosity in theXPDgene (codon 751) increased cancer risk: OR (95% CI) = 1.36 (1.03–1.81),p=0.031. The frequency of theXPD312Asn allele was significantly higher in T ≥ 2 high grade than in T ≥ 2 low grade tumorsp=0.036; theERCC61097Val/Val genotype was strongly associated with muscle-invasive tumors. Combinations of homozygous wild type alleles occurred with the increased frequency in patients with non-muscle-invasive tumors suggesting that the maintenance of normal DNA repair activity may prevent cancer progression.

Abstract 5618: Polymorphisms in DNA repair genes are associated with endometrial cancer risk among Japanese women

2011 ◽  
Author(s):  
Satoyo Hosono ◽  
Keitaro Matsuo ◽  
Hidemi Ito ◽  
Kaoru Hirose ◽  
Miki Watanabe ◽  
...  
Keyword(s):  
Dna Repair ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Japanese Women ◽  
Dna Repair Genes ◽  
Endometrial Cancer Risk ◽  
Repair Genes
Sign in / Sign up

Export Citation Format

Share Document