scholarly journals The Pharmacological Potential of Oil Palm Phenolics (OPP) Individual Components

2019 ◽  
Vol 16 (5) ◽  
pp. 711-719 ◽  
Author(s):  
Syed-Badrul Syarifah-Noratiqah ◽  
Mohamed S Zulfarina ◽  
Shihab Uddin Ahmad ◽  
Syed Fairus ◽  
Isa Naina-Mohamed
Keyword(s):  
Oil Palm ◽  
Oil Palm Phenolics ◽  
Pharmacological Potential

Effect of oil palm phenolics on gastrointestinal transit, contractility and motility in the rat

2015 ◽  
Vol 17 ◽  
pp. 928-937 ◽  
Author(s):  
Glen S. Patten ◽  
Mahinda Y. Abeywardena ◽  
Kalyana Sundram ◽  
Yew Ai Tan ◽  
Ravigadevi Sambanthamurthi
Keyword(s):  
Oil Palm ◽  
Gastrointestinal Transit ◽  
Oil Palm Phenolics

scholarly journals Gene Expression Changes in Spleens and Livers of Tumour-Bearing Mice Suggest Delayed Inflammation and Attenuated Cachexia in Response to Oil Palm Phenolics

2013 ◽  
Vol 6 (6) ◽  
pp. 305-326 ◽  
Author(s):  
Soon-Sen Leow ◽  
Shamala Devi Sekaran ◽  
Kalyana Sundram ◽  
YewAi Tan ◽  
Ravigadevi Sambanthamurthi
Keyword(s):  
Gene Expression ◽  
Oil Palm ◽  
Tumour Bearing ◽  
Oil Palm Phenolics

scholarly journals The in vivo effect of oil palm phenolics (OPP) in atherogenic diet induced rat model of Alzheimer's Disease (AD)

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Yan Wu ◽  
Vindhyaja Srirajavatsavai ◽  
Kenechukwu Monplaisir ◽  
Ravigadevi Sambanthamurthi ◽  
Smiti Gupta
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rat Model ◽  
Oil Palm ◽  
Atherogenic Diet ◽  
Model Of Alzheimer’S Disease ◽  
Oil Palm Phenolics

scholarly journals Effect of oil palm phenolics (OPP) on pancreatic cancer (PC) in transgenic mouse model (KPC)

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Shilpa Vemuri ◽  
Arvind Goja ◽  
Nadia Sadaat ◽  
Poornima Gowthaman ◽  
Michael Chrusciel ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Oil Palm ◽  
Transgenic Mouse Model ◽  
Oil Palm Phenolics

scholarly journals Supplementation of oil palm phenolics in normal healthy human volunteers

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Syed Fairus ◽  
Soon‐Sen Leow ◽  
Naina Mohamed Isa ◽  
Kalyana Sundram ◽  
Kenneth C Hayes ◽  
...  
Keyword(s):  
Oil Palm ◽  
Healthy Human ◽  
Human Volunteers ◽  
Oil Palm Phenolics

scholarly journals The Effects and Potential Mechanism of Oil Palm Phenolics in Cardiovascular Health: A Review on Current Evidence

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 2055
Author(s):  
Nurul ‘Izzah Ibrahim ◽  
Syed Fairus ◽  
Isa Naina Mohamed
Keyword(s):  
Side Effects ◽  
Oil Palm ◽  
Cardiovascular Health ◽  
Lifestyle Modification ◽  
Cholesterol Biosynthesis ◽  
Density Lipoprotein ◽  
Water Soluble ◽  
Current Evidence ◽  
Cardioprotective Effects ◽  
Oil Palm Phenolics

Cardiovascular disease (CVD) is globally known as the number one cause of death with hyperlipidemia as a strong risk factor for CVD. The initiation of drug treatment will be recommended if lifestyle modification fails. However, medicines currently used for improving cholesterol and low-density lipoprotein cholesterols (LDL-C) levels have been associated with various side effects. Thus, alternative treatment with fewer or no side effects needs to be explored. A potential agent, oil palm phenolics (OPP) recovered from the aqueous waste of oil palm milling process contains numerous water-soluble phenolic compounds. It has been postulated that OPP has shown cardioprotective effects via several mechanisms such as cholesterol biosynthesis pathway, antioxidant and anti-inflammatory properties. This review aims to summarize the current evidence explicating the actions of OPP in cardiovascular health and the mechanisms that maybe involved for the cardioprotective effects.

scholarly journals Oil Palm Phenolics Inhibit theIn VitroAggregation ofβ-Amyloid Peptide into Oligomeric Complexes

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Robert P. Weinberg ◽  
Vera V. Koledova ◽  
Hyeari Shin ◽  
Jennifer H. Park ◽  
Yew Ai Tan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Oil Palm ◽  
Elaeis Guineensis ◽  
Genetically Engineered ◽  
Amyloid Peptide ◽  
Palm Tree ◽  
Transgenic Yeast ◽  
Oil Palm Phenolics

Alzheimer’s disease is a severe neurodegenerative disease characterized by the aggregation of amyloid-βpeptide (Aβ) into toxic oligomers which activate microglia and astrocytes causing acute neuroinflammation. Multiple studies show that the soluble oligomers of Aβ42 are neurotoxic and proinflammatory, whereas the monomers and insoluble fibrils are relatively nontoxic. We show that Aβ42 aggregation is inhibitedin vitroby oil palm phenolics (OPP), an aqueous extract from the oil palm tree(Elaeis guineensis). The data shows that OPP inhibits stacking ofβ-pleated sheets, which is essential for oligomerization. We demonstrate the inhibition of Aβ42 aggregation by (1) mass spectrometry; (2) Congo Red dye binding; (3) 2D-IR spectroscopy; (4) dynamic light scattering; (5) transmission electron microscopy; and (6) transgenic yeast rescue assay. In the yeast rescue assay, OPP significantly reduces the cytotoxicity of aggregating neuropeptides in yeast genetically engineered to overexpress these peptides. The data shows that OPP inhibits (1) the aggregation of Aβinto oligomers; (2) stacking ofβ-pleated sheets; and (3) fibrillar growth and coalescence. These inhibitory effects prevent the formation of neurotoxic oligomers and hold potential as a means to reduce neuroinflammation and neuronal death and thereby may play some role in the prevention or treatment of Alzheimer’s disease.

scholarly journals Positive outcomes of oil palm phenolics on degenerative diseases in animal models

2011 ◽  
Vol 106 (11) ◽  
pp. 1664-1675 ◽  
Author(s):  
Ravigadevi Sambanthamurthi ◽  
YewAi Tan ◽  
Kalyana Sundram ◽  
Kenneth C. Hayes ◽  
Mahinda Abeywardena ◽  
...  
Keyword(s):  
Animal Models ◽  
Cancer Progression ◽  
Oil Palm ◽  
Molecular Mechanisms ◽  
Biological Activities ◽  
Atherogenic Diet ◽  
Positive Effects ◽  
The Metabolic Syndrome ◽  
Oil Palm Phenolics ◽  
Microarray Studies

It is well established that plant phenolics elicit various biological activities, with positive effects on health. Palm oil production results in large volumes of aqueous by-products containing phenolics. In the present study, we describe the effects of oil palm phenolics (OPP) on several degenerative conditions using various animal models. OPP reduced blood pressure in a NO-deficient rat model, protected against ischaemia-induced cardiac arrhythmia in rats and reduced plaque formation in rabbits fed an atherogenic diet. In Nile rats, a spontaneous model of the metabolic syndrome and type 2 diabetes, OPP protected against multiple aspects of the syndrome and diabetes progression. In tumour-inoculated mice, OPP protected against cancer progression. Microarray studies on the tumours showed differential transcriptome profiles that suggest anti-tumour molecular mechanisms involved in OPP action. Thus, initial studies suggest that OPP may have potential against several chronic disease outcomes in mammals.

scholarly journals Oil palm phenolics confer neuroprotective effects involving cognitive and motor functions in mice

2013 ◽  
Vol 16 (5) ◽  
pp. 207-217 ◽  
Author(s):  
Soon-Sen Leow ◽  
Shamala Devi Sekaran ◽  
YewAi Tan ◽  
Kalyana Sundram ◽  
Ravigadevi Sambanthamurthi
Keyword(s):  
Oil Palm ◽  
Neuroprotective Effects ◽  
Motor Functions ◽  
Oil Palm Phenolics
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