scholarly journals T Cell Immunity To Enterovirus 71 Infection In Humans And Implications For Vaccine Development

2018 ◽  
Vol 15 (11) ◽  
pp. 1143-1152 ◽  
Author(s):  
Pinn Tsin Isabel Yee ◽  
Chit Laa Poh
Keyword(s):  
T Cell ◽  
Vaccine Development ◽  
Enterovirus 71 ◽  
T Cell Immunity ◽  
Cell Immunity ◽  
Enterovirus 71 Infection

T Cell Immunity and Zika Virus Vaccine Development

2017 ◽  
Vol 38 (8) ◽  
pp. 594-605 ◽  
Author(s):  
Noemia S. Lima ◽  
Morgane Rolland ◽  
Kayvon Modjarrad ◽  
Lydie Trautmann
Keyword(s):  
T Cell ◽  
Virus Vaccine ◽  
Zika Virus ◽  
Vaccine Development ◽  
T Cell Immunity ◽  
Cell Immunity

scholarly journals T-cell immunity of SARS-CoV: Implications for vaccine development against MERS-CoV

2017 ◽  
Vol 137 ◽  
pp. 82-92 ◽  
Author(s):  
William J. Liu ◽  
Min Zhao ◽  
Kefang Liu ◽  
Kun Xu ◽  
Gary Wong ◽  
...  
Keyword(s):  
T Cell ◽  
Vaccine Development ◽  
T Cell Immunity ◽  
Cell Immunity

scholarly journals The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo

2005 ◽  
Vol 201 (4) ◽  
pp. 567-577 ◽  
Author(s):  
Jianuo Liu ◽  
Takashi Miwa ◽  
Brendan Hilliard ◽  
Youhai Chen ◽  
John D. Lambris ◽  
...  
Keyword(s):  
T Cell ◽  
Vaccine Development ◽  
T Cell Immunity ◽  
Cell Secretion ◽  
Inhibitory Protein ◽  
Cell Immunity ◽  
Ifn Γ ◽  
Eae Model

Decay-accelerating factor ([DAF] CD55) is a glycosylphosphatidylinositol-anchored membrane inhibitor of complement with broad clinical relevance. Here, we establish an additional and unexpected role for DAF in the suppression of adaptive immune responses in vivo. In both C57BL/6 and BALB/c mice, deficiency of the Daf1 gene, which encodes the murine homologue of human DAF, significantly enhanced T cell responses to active immunization. This phenotype was characterized by hypersecretion of interferon (IFN)-γ and interleukin (IL)-2, as well as down-regulation of the inhibitory cytokine IL-10 during antigen restimulation of lymphocytes in vitro. Compared with wild-type mice, Daf1−/− mice also displayed markedly exacerbated disease progression and pathology in a T cell–dependent experimental autoimmune encephalomyelitis (EAE) model. However, disabling the complement system in Daf1−/− mice normalized T cell secretion of IFN-γ and IL-2 and attenuated disease severity in the EAE model. These findings establish a critical link between complement and T cell immunity and have implications for the role of DAF and complement in organ transplantation, tumor evasion, and vaccine development.

scholarly journals Insights into innate and adaptive immune responses in vaccine development against EV-A71

2019 ◽  
Vol 7 ◽  
pp. 251513551988899 ◽  
Author(s):  
Hui Xuan Lim ◽  
Chit Laa Poh
Keyword(s):  
T Cell ◽  
Cellular Immunity ◽  
Vaccine Development ◽  
Foot And Mouth Disease ◽  
T Cell Immunity ◽  
Effective Vaccine ◽  
Cell Immunity ◽  
Causative Agents ◽  
Us Fda

Enterovirus A71 (EV-A71) is one of the major causative agents of hand, foot and mouth disease (HFMD) in the world, infecting mostly infants and young children (<5 years of age) in Asia. Approximately 2 million cases of HFMD were reported in China each year, of which approximately 45–50% were due to EV-A71. Most of the HFMD infections caused by EV-A71 usually result in mild symptoms with rashes and ulcers in the mouth. However, virulent strains of EV-A71 can infect the central nervous system and cause severe neurologic diseases, leading to reduced cognitive ability, acute flaccid paralysis and death. The lack of understanding of cellular immunity for long-term protection from the HFMD disease represents a major obstacle for vaccine development. In particular, the role of innate and T cell immunity during HFMD infection remains unclear and there is evidence suggesting the importance of CD4+ and CD8+ T cells for protective immunity. Currently, no US FDA-approved vaccine is available for EV-A71. Although the inactivated vaccines produced in China are highly effective (vaccine efficacy >95%), they lack the cellular immunity required for long-term protection. In this review, we discuss the findings that support the protective roles of innate and T cell immunity against EV-A71 infection, which will provide the knowledge needed for the urgent development of efficacious vaccines that will confer long-term protection.

Role of CD8+T-cell immunity in influenza infection: potential use in future vaccine development

2009 ◽  
Vol 3 (5) ◽  
pp. 523-537 ◽  
Author(s):  
Nicole La Gruta ◽  
Anne Kelso ◽  
Lorena E Brown ◽  
Wiesan Chen ◽  
David C Jackson ◽  
...  
Keyword(s):  
T Cell ◽  
Vaccine Development ◽  
Influenza Infection ◽  
Cd8 T Cell ◽  
T Cell Immunity ◽  
Cell Immunity ◽  
Potential Use

IL-7 and IL-15: Biology and Roles in T-Cell Immunity in Health and Disease

2008 ◽  
Vol 28 (4) ◽  
pp. 325-339 ◽  
Author(s):  
Hang-Rae Kim ◽  
Kyung-A Hwang ◽  
Sung-Hwan Park ◽  
Insoo Kang
Keyword(s):  
T Cell ◽  
T Cell Immunity ◽  
Cell Immunity ◽  
Health And Disease
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