scholarly journals Critical Role of p53 and K-ras in the Diagnosis of Early Colorectal Cancer: a One-year, Single-center Analysis

2017 ◽  
Vol 14 (11) ◽  
pp. 1154-1162 ◽  
Author(s):  
Hui-Ying Lu ◽  
Ri-Tian Lin ◽  
Guang-Xi Zhou ◽  
Tian-Ming Yu ◽  
Zhan-Ju Liu
Keyword(s):  
Colorectal Cancer ◽  
Critical Role ◽  
Early Colorectal Cancer ◽  
Single Center ◽  
One Year

The Critical Role of the miR-21-MEG2 Axis in Colorectal Cancer

2020 ◽  
Vol 30 (6) ◽  
pp. 509-518
Author(s):  
Zengtao Bao ◽  
Shanting Gao ◽  
Baoming Zhang ◽  
Wenchao Shi ◽  
Aimin Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Critical Role

The potential role of microRNA-31 expression in early colorectal cancer

2015 ◽  
Vol 65 (10) ◽  
pp. 513-518 ◽  
Author(s):  
Yoko Tateishi ◽  
Koji Okudela ◽  
Hideaki Mitsui ◽  
Shigeaki Umeda ◽  
Takehisa Suzuki ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Potential Role ◽  
Early Colorectal Cancer

The Critical Role of Dysregulated RhoB Signaling Pathway in Radioresistance of Colorectal Cancer

2019 ◽  
Vol 104 (5) ◽  
pp. 1153-1164 ◽  
Author(s):  
Na Liu ◽  
Weiyingqi Cui ◽  
Xia Jiang ◽  
Zhiyong Zhang ◽  
Sebastian Gnosa ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Signaling Pathway ◽  
Critical Role

OC.14.2: Critical Role of the IL-33/ST2 Axis in Colitis-Associated Colorectal Cancer

2017 ◽  
Vol 49 ◽  
pp. e117
Author(s):  
L.R. Lopetuso ◽  
C. De Salvo ◽  
L. Di Martino ◽  
W. Goodman ◽  
F. Scaldaferri ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Critical Role

scholarly journals Roles of Lipid Peroxidation-Derived Electrophiles in Pathogenesis of Colonic Inflammation and Colon Cancer

2021 ◽  
Vol 9 ◽  
Author(s):  
Lei Lei ◽  
Jianan Zhang ◽  
Eric A. Decker ◽  
Guodong Zhang
Keyword(s):  
Colorectal Cancer ◽  
Lipid Peroxidation ◽  
Critical Role ◽  
Redox Stress ◽  
Colonic Inflammation ◽  
Colon Tumorigenesis ◽  
Inflammatory Bowel

Redox stress is a common feature of gut disorders such as colonic inflammation (inflammatory bowel disease or IBD) and colorectal cancer (CRC). This leads to increased colonic formation of lipid-derived electrophiles (LDEs) such as 4-hydroxynonenal (4-HNE), malondialdehyde (MDA), trans, trans-2,4-decadienal (tt-DDE), and epoxyketooctadecenoic acid (EKODE). Recent research by us and others support that treatment with LDEs increases the severity of colitis and exacerbates the development of colon tumorigenesis in vitro and in vivo, supporting a critical role of these compounds in the pathogenesis of IBD and CRC. In this review, we will discuss the effects and mechanisms of LDEs on development of IBD and CRC and lifestyle factors, which could potentially affect tissue levels of LDEs to regulate IBD and CRC development.

Su1861 Critical Role of the IL-33/ST2 Axis in Colitis-Associated Colorectal Cancer

2016 ◽  
Vol 150 (4) ◽  
pp. S573
Author(s):  
Loris R. Lopetuso ◽  
Carlo De Salvo ◽  
Luca Di Martino ◽  
Wendy Goodman ◽  
Franco Scaldaferri ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Critical Role
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