scholarly journals The Therapeutic Effect of Vitamin C in an Animal Model of Complex Regional Pain Syndrome Produced by Prolonged Hindpaw Ischemia-Reperfusion in Rats

2017 ◽  
Vol 14 (1) ◽  
pp. 97-101 ◽  
Author(s):  
Jae Hun Kim ◽  
Yong Chul Kim ◽  
Francis Sahngun Nahm ◽  
Pyung Bok Lee
Keyword(s):  
Animal Model ◽  
Vitamin C ◽  
Complex Regional Pain Syndrome ◽  
Therapeutic Effect ◽  
Ischemia Reperfusion ◽  
Pain Syndrome

scholarly journals Proteomic Identification of Altered Cerebral Proteins in the Complex Regional Pain Syndrome Animal Model

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Francis Sahngun Nahm ◽  
Zee-Yong Park ◽  
Sang-Soep Nahm ◽  
Yong Chul Kim ◽  
Pyung Bok Lee
Keyword(s):  
Animal Model ◽  
Complex Regional Pain Syndrome ◽  
Proteomic Analysis ◽  
Protein Identification ◽  
Pain Syndrome ◽  
Differentially Expressed ◽  
Control Groups ◽  
Altered Expression ◽  
Rat Cerebrum ◽  
And Control

Background. Complex regional pain syndrome (CRPS) is a rare but debilitating pain disorder. Although the exact pathophysiology of CRPS is not fully understood, central and peripheral mechanisms might be involved in the development of this disorder. To reveal the central mechanism of CRPS, we conducted a proteomic analysis of rat cerebrum using the chronic postischemia pain (CPIP) model, a novel experimental model of CRPS.Materials and Methods. After generating the CPIP animal model, we performed a proteomic analysis of the rat cerebrum using a multidimensional protein identification technology, and screened the proteins differentially expressed between the CPIP and control groups.Results. A total of 155 proteins were differentially expressed between the CPIP and control groups: 125 increased and 30 decreased; expressions of proteins related to cell signaling, synaptic plasticity, regulation of cell proliferation, and cytoskeletal formation were increased in the CPIP group. However, proenkephalin A, cereblon, and neuroserpin were decreased in CPIP group.Conclusion. Altered expression of cerebral proteins in the CPIP model indicates cerebral involvement in the pathogenesis of CRPS. Further study is required to elucidate the roles of these proteins in the development and maintenance of CRPS.

scholarly journals Anti-Allodynic Effects of Polydeoxyribonucleotide in an Animal Model of Neuropathic Pain and Complex Regional Pain Syndrome

2020 ◽  
Vol 35 (26) ◽  
Author(s):  
Sung Hyun Lee ◽  
Sie Hyeon Yoo ◽  
Hae-Jin Lee ◽  
Donggyu Han ◽  
Jiyoung Lee ◽  
...  
Keyword(s):  
Animal Model ◽  
Neuropathic Pain ◽  
Complex Regional Pain Syndrome ◽  
Pain Syndrome

Can Vitamin C Prevent Complex Regional Pain Syndrome in Patients with Wrist Fractures?

2007 ◽  
Vol 89 (7) ◽  
pp. 1424-1431 ◽  
Author(s):  
P. E. Zollinger ◽  
W. E. Tuinebreijer ◽  
R. S. Breederveld ◽  
R. W. Kreis
Keyword(s):  
Vitamin C ◽  
Complex Regional Pain Syndrome ◽  
Pain Syndrome ◽  
Wrist Fractures

scholarly journals The influence of vitamin C on the outcome of ankle fractures. A protocol of double-blind RCT

2017 ◽  
Vol 2 (3) ◽  
pp. 2473011417S0000
Author(s):  
Abduljabbar Alhammoud ◽  
Ghalib Ahmed
Keyword(s):  
Vitamin C ◽  
Fracture Healing ◽  
Functional Outcome ◽  
Distal Radius Fracture ◽  
Complex Regional Pain Syndrome ◽  
Distal Radius ◽  
Ankle Fracture ◽  
Pain Syndrome ◽  
Foot And Ankle ◽  
Double Blind

Category: Ankle, Trauma Introduction/Purpose: Ankle fracture is one of the most common orthopedics injuries. Poor functional outcome, residual pain and discomfort is a major burden to the patients daily activities Complex regional pain syndrome (CRPS) is one of serious complication after orthopedics injuries .The incidence of CRPS is 0.3% after foot and ankle surgery. CRPS is well studied in wrist fracture. Vitamin C has been proposed to improve outcomes after a distal radius fracture by promotion of bone and soft-tissue healing and reducing the prevalence of complex regional pain syndrome (CRPS). We aim to detect the effect of vitamin C on the functional outcome, post op pain, incidence of CRPS, wound healing and fracture healing after an ankle fracture Methods: Prospective, Double blind, Randomized control study of 110 subjects (55 subjects in each group). Subjects in study group will receive 500 mg vitamin C for 50 days and standard of care, whereas control group will receive the stander of care alone. Subjects with age from 18-50 years old, with ankle fracture which treated surgically will be recruited, whereas open fracture, Peripheral vascular disease, Allergy to Vitamin C will be excluded. Subjects will be followed up in regular basis for one year. Primary end point will be diagnosis of CRPS and secondary end point will be failure of initial management Results: Although CRPS is more common in wrist injuries comparing to ankle injuries, subclinical of CRPS is more common after ankle fracture. Vitamin C showed promising results in decrease the incidence of CRPS in distal radius fracture. Literature lack of studies looking for CRPS and foot and ankle fracture without high evidence of effect of vitamin C on the functional outcome and post op pain after ankle fractures. Conclusion: We assume that vitamin C will improve functional outcome, decrease post op pain, decrease the incidence of CRPS and improve wound and fracture healing.

scholarly journals Role of peripheral endothelin receptors in an animal model of complex regional pain syndrome type 1 (CRPS-I)

Pain ◽  
2010 ◽  
Vol 151 (1) ◽  
pp. 174-183 ◽  
Author(s):  
Magali Millecamps ◽  
Andre Laferrière ◽  
Vaigunda J. Ragavendran ◽  
Laura S. Stone ◽  
Terence J. Coderre
Keyword(s):  
Animal Model ◽  
Complex Regional Pain Syndrome ◽  
Pain Syndrome ◽  
Endothelin Receptors ◽  
Syndrome Type

scholarly journals Role of NFκB in an Animal Model of Complex Regional Pain Syndrome–type I (CRPS-I)

2009 ◽  
Vol 10 (11) ◽  
pp. 1161-1169 ◽  
Author(s):  
Marissa de Mos ◽  
André Laferrière ◽  
Magali Millecamps ◽  
Mercedes Pilkington ◽  
Miriam C.J.M. Sturkenboom ◽  
...  
Keyword(s):  
Animal Model ◽  
Complex Regional Pain Syndrome ◽  
Pain Syndrome ◽  
Type I ◽  
Syndrome Type
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