Enhancing Transgene Expression from Recombinant AAV8 Vectors in Different Tissues Using Woodchuck Hepatitis Virus Post-Transcriptional Regulatory Element

Lizheng Wang; Zixuan Wang; Fangfang Zhang; Rui Zhu; Jinpeng Bi; Jiaxin Wu; Haihong Zhang; Hui Wu; Wei Kong; Bin Yu; Xianghui Yu

doi:10.7150/ijms.14152

Enhancing Transgene Expression from Recombinant AAV8 Vectors in Different Tissues Using Woodchuck Hepatitis Virus Post-Transcriptional Regulatory Element

International Journal of Medical Sciences ◽

10.7150/ijms.14152 ◽

2016 ◽

Vol 13 (4) ◽

pp. 286-291 ◽

Cited By ~ 7

Author(s):

Lizheng Wang ◽

Zixuan Wang ◽

Fangfang Zhang ◽

Rui Zhu ◽

Jinpeng Bi ◽

...

Keyword(s):

Transgene Expression ◽

Hepatitis Virus ◽

Regulatory Element ◽

Woodchuck Hepatitis Virus ◽

Transcriptional Regulatory Element ◽

Transcriptional Regulatory ◽

Different Tissues

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Enhancement of Green Fluorescent Protein Expression in Adeno-Associated Virus with the Woodchuck Hepatitis Virus Post-Transcriptional Regulatory Element

Green Fluorescent Protein ◽

10.1385/1-59259-280-5:331 ◽

2003 ◽

pp. 331-340 ◽

Cited By ~ 1

Author(s):

Jonathan E. Loeb ◽

Matthew D. Weitzman ◽

Thomas J. Hope

Keyword(s):

Green Fluorescent Protein ◽

Protein Expression ◽

Fluorescent Protein ◽

Hepatitis Virus ◽

Regulatory Element ◽

Woodchuck Hepatitis Virus ◽

Adeno Associated Virus ◽

Transcriptional Regulatory Element ◽

Transcriptional Regulatory ◽

Green Fluorescent

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828. Optimizing the Woodchuck Hepatitis Virus Post-Transcriptional Regulatory Element (WPRE) for Safety and Function in Lentiviral Vectors

Molecular Therapy ◽

10.1016/j.ymthe.2005.07.371 ◽

2005 ◽

Vol 11 ◽

pp. S322

Keyword(s):

Hepatitis Virus ◽

Regulatory Element ◽

Lentiviral Vectors ◽

Woodchuck Hepatitis Virus ◽

Transcriptional Regulatory Element ◽

Transcriptional Regulatory ◽

And Function

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Enhancement of plasmid-mediated stable gene expression by woodchuck hepatitis virus post-transcriptional regulatory element (WPRE) in human embryonic kidney (HEK293) cells

AFRICAN JOURNAL OF BIOTECHNOLOGY ◽

10.5897/ajb12.399 ◽

2012 ◽

Vol 4 (47) ◽

Author(s):

Lingling Ye

Keyword(s):

Gene Expression ◽

Hepatitis Virus ◽

Regulatory Element ◽

Hek293 Cells ◽

Woodchuck Hepatitis Virus ◽

Stable Gene ◽

Human Embryonic Kidney ◽

Transcriptional Regulatory Element ◽

Transcriptional Regulatory ◽

Stable Gene Expression

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The woodchuck hepatitis virus post-transcriptional regulatory element reduces readthrough transcription from retroviral vectors

Gene Therapy ◽

10.1038/sj.gt.3302979 ◽

2007 ◽

Vol 14 (17) ◽

pp. 1298-1304 ◽

Cited By ~ 41

Author(s):

T Higashimoto ◽

F Urbinati ◽

A Perumbeti ◽

G Jiang ◽

A Zarzuela ◽

...

Keyword(s):

Hepatitis Virus ◽

Regulatory Element ◽

Retroviral Vectors ◽

Woodchuck Hepatitis Virus ◽

Transcriptional Regulatory Element ◽

Transcriptional Regulatory

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Woodchuck hepatitis virus post-transcriptional regulatory element deleted from X protein and promoter sequences enhances retroviral vector titer and expression

Gene Therapy ◽

10.1038/sj.gt.3302698 ◽

2005 ◽

Vol 13 (7) ◽

pp. 641-645 ◽

Cited By ~ 102

Author(s):

A Schambach ◽

J Bohne ◽

C Baum ◽

F G Hermann ◽

L Egerer ◽

...

Keyword(s):

Hepatitis Virus ◽

Regulatory Element ◽

Retroviral Vector ◽

Woodchuck Hepatitis Virus ◽

X Protein ◽

Promoter Sequences ◽

Transcriptional Regulatory Element ◽

Transcriptional Regulatory ◽

Vector Titer

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775. The Woodchuck Hepatitis Virus Post-Transcriptional Regulatory Element Reduces Readthrough Transcription from Retroviral Vectors To Improve Vector Titers and Expression

Molecular Therapy ◽

10.1016/s1525-0016(16)44981-6 ◽

2007 ◽

Vol 15 ◽

pp. S298-S299

Keyword(s):

Hepatitis Virus ◽

Regulatory Element ◽

Retroviral Vectors ◽

Woodchuck Hepatitis Virus ◽

Transcriptional Regulatory Element ◽

Transcriptional Regulatory

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275. Effect of the Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element (WPRE) on Transgene Expression Controlled by the Human Synapsin 1 Gene Promoter Following Adenoviral-Mediated Gene Delivery

Molecular Therapy ◽

10.1016/s1525-0016(16)44481-3 ◽

2007 ◽

Vol 15 ◽

pp. S104-S105

Keyword(s):

Gene Delivery ◽

Transgene Expression ◽

Hepatitis Virus ◽

Regulatory Element ◽

Gene Promoter ◽

Woodchuck Hepatitis Virus ◽

Posttranscriptional Regulatory Element ◽

Synapsin 1

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B-cell-specific transgene expression using a self-inactivating retroviral vector with human CD19 promoter and viral post-transcriptional regulatory element

Gene Therapy ◽

10.1038/sj.gt.3302255 ◽

2004 ◽

Vol 11 (12) ◽

pp. 992-1000 ◽

Cited By ~ 30

Author(s):

M Werner ◽

J Kraunus ◽

C Baum ◽

T Brocker

Keyword(s):

B Cell ◽

Transgene Expression ◽

Regulatory Element ◽

Retroviral Vector ◽

Transcriptional Regulatory Element ◽

Transcriptional Regulatory

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603. Towards High-Level and Cell Specific Transgene Expression: The Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element (WPRE) Increases Expression Mediated by the Synapsin Promoter with No Loss of Neuron Specificity

Molecular Therapy ◽

10.1016/s1525-0016(16)43433-7 ◽

2002 ◽

Vol 5 (5) ◽

pp. S197

Keyword(s):

Transgene Expression ◽

Hepatitis Virus ◽

Regulatory Element ◽

Woodchuck Hepatitis Virus ◽

High Level ◽

Posttranscriptional Regulatory Element

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Influence of promoter and WHV post-transcriptional regulatory element on AAV-mediated transgene expression in the rat brain

Gene Therapy ◽

10.1038/sj.gt.3301221 ◽

2000 ◽

Vol 7 (15) ◽

pp. 1304-1311 ◽

Cited By ~ 128

Author(s):

J-C Paterna ◽

T Moccetti ◽

A Mura ◽

J Feldon ◽

H Büeler

Keyword(s):

Rat Brain ◽

Transgene Expression ◽

Regulatory Element ◽

Transcriptional Regulatory Element ◽

Transcriptional Regulatory

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