scholarly journals Relationship of Genetic Polymorphisms of Aldosterone Synthase Gene Cytochrome P450 11B2 and Mineralocorticoid Receptors with Coronary Artery Disease in Taiwan

2016 ◽  
Vol 13 (2) ◽  
pp. 117-123 ◽  
Author(s):  
Chi-Hung Chou ◽  
Kwo-Chang Ueng ◽  
Shun-Fa Yang ◽  
Chih-Hsien Wu ◽  
Po-Hui Wang
Keyword(s):  
Coronary Artery Disease ◽  
Cytochrome P450 ◽  
Coronary Artery ◽  
Genetic Polymorphisms ◽  
Mineralocorticoid Receptors ◽  
Aldosterone Synthase ◽  
Artery Disease ◽  
Relationship Of

A GENETIC AND METABOLIC STUDY OF A FAMILY WITH HYPERLIPEMIA

PEDIATRICS ◽  
1962 ◽  
Vol 29 (4) ◽  
pp. 566-578
Author(s):  
George Bialkin ◽  
Saul Zucker ◽  
Burton S. Sklarin ◽  
Kurt Hirschhorn ◽  
Murray Davidson
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Lipid Levels ◽  
Metabolic Study ◽  
Diagnosis And Prognosis ◽  
The Family ◽  
Artery Disease ◽  
Pathologic Physiology ◽  
Relationship Of ◽  
The Relationship

A family consisting of a mother and father, heterozygous for idiopathic hyperlipemia, and their four offspring, one heterozygous and three homozygous for the disease, are described. In addition, a fifth child who is heterozygous, born of same mother but by another incompletely studied father, is presented. The genetics of the disease in this family, and also in the general population, with emphasis on diagnosis and prognosis in heterozygotes is discussed. The interrelationship of various lipid components in serum and their metabolism are briefly reviewed. The possible defective mechanisms in hyperlipemia, the techniques for deciding on the specific defect, and their application to the members of this family are reviewed. The effect of heparin, nicotinic acid, and fat-free diets in the homozygous members of the family are evaluated and their therapeutic applications are discussed. The symptomatology, possible pathologic physiology, relationship to lipid levels in serum and occurrence of abdominal crises in some of the homozygous members of this family are pointed out. The relationship of cholesterol and triglyceride levels in serum to, and the significance of, idiopathic hyperlipemia in the genesis of, atherosclerosis and coronary artery disease is elucidated.

scholarly journals The relationship of Charlson comorbidity index with stent restenosis and extent of coronary artery disease

2018 ◽  
Vol 10 (2) ◽  
pp. 70-75 ◽  
Author(s):  
Turgut Karabağ ◽  
Emіne Altuntaş ◽  
Belma Kalaycı ◽  
Bahar Şahіn ◽  
Mustafa Umut Somuncu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Charlson Comorbidity Index ◽  
Stent Restenosis ◽  
Comorbidity Index ◽  
Artery Disease ◽  
Relationship Of ◽  
The Relationship

The Relationship of Mitral Valve Prolapse to Obstructive Coronary Artery Disease

Cardiology ◽  
1979 ◽  
Vol 64 (1) ◽  
pp. 48-57 ◽  
Author(s):  
Fulvío Pileggi ◽  
Paulo Roberto Camargo ◽  
Egas Armelin ◽  
Giovanni Bellotti ◽  
Protásio da Luz ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Mitral Valve ◽  
Mitral Valve Prolapse ◽  
Obstructive Coronary Artery Disease ◽  
Artery Disease ◽  
Relationship Of ◽  
The Relationship

Genetic variants of PEAR1 and ischemic clinical outcomes in coronary artery disease patients: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Xinyi Zhang ◽  
Sicong Li ◽  
Yuxuan Zhao ◽  
Ningjia Tang ◽  
Tong Jia ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Clinical Outcomes ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Electronic Database ◽  
Artery Disease ◽  
Relationship Of ◽  
The Relationship ◽  
Ischemic Events

Aim: The aim of this study was to assess the association between PEAR1 polymorphisms and ischemic clinical outcomes. Materials & methods: We searched the electronic database for articles on the relationship of PEAR1 SNPs and ischemic events in patients with coronary artery disease (CAD) up to October 2020. Results: A total of 9914 patients with CAD from six studies focusing on 12 SNPs of PEAR1 were included in this study. The A allele of rs12041331 were associated with ischemic events (odds ratio: 1.40; 95% CI: 1.04–1.88; p = 0.03). The AA homozygotes of rs2768759 was related to a higher risk of ischemic events than carriers of the C allele (odds ratio: 2.08; 95% CI: 1.09–3.97; p = 0.03). Conclusion: PEAR1 rs12041331 and rs2768759 are significantly associated with ischemic events in patients with CAD.

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