scholarly journals A Novel Aurora-A Inhibitor, BPR1K0609S1, Sensitizes Colorectal Tumor cells to 5-Fluorofracil (5-FU) Treatment

2013 ◽  
Vol 9 (9) ◽  
pp. 947-947
Author(s):  
Yoshimi Shionome ◽  
Wen-Hsing Lin ◽  
Hui-Yi Shiao ◽  
Hsing-Pang Hsieh ◽  
John Tsu-An Hsu ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Colorectal Tumor ◽  
Aurora A

scholarly journals A Novel Aurora-A Inhibitor, BPR1K0609S1, Sensitizes Colorectal Tumor cells to 5-Fluorofracil (5-FU) Treatment

2013 ◽  
Vol 9 (4) ◽  
pp. 403-411 ◽  
Author(s):  
Yoshimi Shionome ◽  
Wen-Hsing Lin ◽  
Hui-Yi Shiao ◽  
Hsing-Pang Hsieh ◽  
John Tsu-An Hsu ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Colorectal Tumor ◽  
Aurora A

Supramolecular Chemotherapy: Noncovalent Bond Synergy of Cucurbit[7]uril against Human Colorectal Tumor Cells

Langmuir ◽  
2021 ◽  
Author(s):  
Yueyue Chen ◽  
Li Jing ◽  
Qingtao Meng ◽  
Bin Li ◽  
Rui Chen ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Colorectal Tumor ◽  
Noncovalent Bond

scholarly journals The Blockade of Tumoral IL1β-Mediated Signaling in Normal Colonic Fibroblasts Sensitizes Tumor Cells to Chemotherapy and Prevents Inflammatory CAF Activation

2021 ◽  
Vol 22 (9) ◽  
pp. 4960
Author(s):  
Natalia Guillén Díaz-Maroto ◽  
Gemma Garcia-Vicién ◽  
Giovanna Polcaro ◽  
María Bañuls ◽  
Nerea Albert ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Tumor Cells ◽  
Cell Types ◽  
Colorectal Tumor ◽  
Cytotoxic Drugs ◽  
Differential Sensitivity ◽  
Paracrine Signaling ◽  
Inflammatory Phenotype ◽  
Heterotypic Interactions ◽  
Carcinoma Associated Fibroblasts

Heterotypic interactions between newly transformed cells and normal surrounding cells define tumor’s fate in incipient carcinomas. Once homeostasis has been lost, normal resident fibroblasts become carcinoma-associated fibroblasts, conferring protumorogenic properties on these normal cells. Here we describe the IL1β-mediated interplay between cancer cells and normal colonic myofibroblasts (NCFs), which bestows differential sensitivity to cytotoxic drugs on tumor cells. We used NCFs, their conditioned media (CM), and cocultures with tumor cells to characterize the IL1β-mediated crosstalk between both cell types. We silenced IL1β in tumor cells to demonstrate that such cells do not exert an influence on NCFs inflammatory phenotype. Our results shows that IL1β is overexpressed in cocultured tumor cells. IL1β enables paracrine signaling in myofibroblasts, converting them into inflammatory-CAFs (iCAF). IL1β-stimulated-NCF-CM induces migration and differential sensitivity to oxaliplatin in colorectal tumor cells. Such chemoprotective effect has not been evidenced for TGFβ1-driven NCFs. IL1β induces the loss of a myofibroblastic phenotype in NCFs and acquisition of iCAF traits. In conclusion, IL1β-secreted by cancer cells modify surrounding normal fibroblasts to confer protumorogenic features on them, particularly tolerance to cytotoxic drugs. The use of IL1β-blocking agents might help to avoid the iCAF traits acquisition and consequently to counteract the protumorogenic actions these cells.

scholarly journals MLN8054, an Inhibitor of Aurora A Kinase, Induces Senescence in Human Tumor Cells Both In vitro and In vivo

2010 ◽  
Vol 8 (3) ◽  
pp. 373-384 ◽  
Author(s):  
Jessica J. Huck ◽  
Mengkun Zhang ◽  
Alice McDonald ◽  
Doug Bowman ◽  
Kara M. Hoar ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Human Tumor ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Human Tumor Cells

scholarly journals Transient infection of freshly isolated human colorectal tumor cells by reovirus T3D intermediate subviral particles

2008 ◽  
Vol 15 (5) ◽  
pp. 284-292 ◽  
Author(s):  
W J van Houdt ◽  
N Smakman ◽  
D J M van den Wollenberg ◽  
B L Emmink ◽  
L M Veenendaal ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Colorectal Tumor ◽  
Subviral Particles

Application of hyperthermia in addition to ionizing irradiation fosters necrotic cell death and HMGB1 release of colorectal tumor cells

2010 ◽  
Vol 391 (1) ◽  
pp. 1014-1020 ◽  
Author(s):  
Petra Schildkopf ◽  
Benjamin Frey ◽  
Frederick Mantel ◽  
Oliver J. Ott ◽  
Eva-Maria Weiss ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Cells ◽  
Colorectal Tumor ◽  
Necrotic Cell Death ◽  
Necrotic Cell ◽  
Ionizing Irradiation

scholarly journals Low dose fractionated radiation enhances the radiosensitization effect of paclitaxel in colorectal tumor cells with mutant p53

Cancer ◽  
2000 ◽  
Vol 89 (9) ◽  
pp. 1893-1900
Author(s):  
Damodaran Chendil ◽  
Rachael Oakes ◽  
Rachael A. Alcock ◽  
Nish Patel ◽  
Christopher Mayhew ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Low Dose ◽  
Colorectal Tumor ◽  
Mutant P53 ◽  
Fractionated Radiation

Stimulation of Clonal Growth of Human Colorectal Tumor Cells by IL-3 and GM-CSF

1990 ◽  
Vol 13 (6) ◽  
pp. 437-443 ◽  
Author(s):  
W.E. Berdel ◽  
S. Danhauser-Riedl ◽  
G. Steinhauser ◽  
J. Rastetter
Keyword(s):  
Tumor Cells ◽  
Clonal Growth ◽  
Colorectal Tumor ◽  
Gm Csf ◽  
Stimulation Of
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