scholarly journals Androgen Receptor as a Driver of Therapeutic Resistance in Advanced Prostate Cancer

2014 ◽  
Vol 10 (6) ◽  
pp. 588-595 ◽  
Author(s):  
Barbara Kahn ◽  
Joanne Collazo ◽  
Natasha Kyprianou
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Advanced Prostate Cancer ◽  
Therapeutic Resistance

scholarly journals Extracellular Vesicles in Advanced Prostate Cancer: Tools to Predict and Thwart Therapeutic Resistance

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3791
Author(s):  
Carolina Saldana ◽  
Amene Majidipur ◽  
Emma Beaumont ◽  
Eric Huet ◽  
Alexandre de la Taille ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Overall Survival ◽  
Androgen Receptor ◽  
Extracellular Vesicles ◽  
Advanced Prostate Cancer ◽  
Initial Response ◽  
Therapeutic Resistance ◽  
Cancer Death ◽  
Cellular Mechanisms

Prostate cancer (PCa) is the second most frequent cancer and the fifth leading cause of cancer death among men worldwide. At first, advanced PCa is treated by androgen deprivation therapy with a good initial response. Nevertheless, recurrences occur, leading to Castrate-Resistance Prostate Cancer (CRPC). During the last decade, new therapies based on inhibition of the androgen receptor pathway or taxane chemotherapies have been used to treat CRPC patients leading to an increase in overall survival, but the occurrence of resistances limits their benefits. Numerous studies have demonstrated the implication of extracellular vesicles (EVs) in different cancer cellular mechanisms. Thus, the possibility to isolate and explore EVs produced by tumor cells in plasma/sera represents an important opportunity for the deciphering of those mechanisms and the discovery of biomarkers. Herein, we summarized the role of EVs in therapeutic resistance of advanced prostate cancer and their use to find biomarkers able to predict these resistances.

scholarly journals A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding Driver in Advanced Prostate Cancer

Cell ◽  
2018 ◽  
Vol 174 (2) ◽  
pp. 422-432.e13 ◽  
Author(s):  
David Y. Takeda ◽  
Sándor Spisák ◽  
Ji-Heui Seo ◽  
Connor Bell ◽  
Edward O’Connor ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Advanced Prostate Cancer

Abstract B14: Developing small-molecule inhibitors to the androgen receptor N-terminus domain for the treatment of advanced prostate cancer

2012 ◽  
Vol 72 (4 Supplement) ◽  
pp. B14-B14
Author(s):  
Marianne D. Sadar ◽  
Jae-Kyung Myung ◽  
Iain McEwan ◽  
Stephen Plymate ◽  
Raymond J. Andersen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Small Molecule ◽  
Advanced Prostate Cancer ◽  
Small Molecule Inhibitors ◽  
N Terminus

scholarly journals Polycomb group proteins EZH2 and EED directly regulate androgen receptor in advanced prostate cancer

2019 ◽  
Vol 145 (2) ◽  
pp. 415-426 ◽  
Author(s):  
Qipeng Liu ◽  
Guangyu Wang ◽  
Qiaqia Li ◽  
Weihua Jiang ◽  
Jung‐Sun Kim ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Advanced Prostate Cancer ◽  
Polycomb Group ◽  
Polycomb Group Proteins
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