scholarly journals LncRNA FAM83A-AS1 facilitates tumor proliferation and the migration via the HIF-1α/ glycolysis axis in lung adenocarcinoma

2022 ◽  
Vol 18 (2) ◽  
pp. 522-535
Author(s):  
Zhencong Chen ◽  
Zhengyang Hu ◽  
Qihai Sui ◽  
Yiwei Huang ◽  
Mengnan Zhao ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Tumor Proliferation

Clinical and therapeutic impact of family with sequence similarity 83, member B in EGFR gene wild type-lung adenocarcinoma.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e23136-e23136
Author(s):  
Takumi Yamaura ◽  
Naoyuki Okabe ◽  
Hironori Takagi ◽  
Yuki Owada ◽  
Takuya Inoue ◽  
...  
Keyword(s):  
Survival Analysis ◽  
Lung Adenocarcinoma ◽  
Cell Lines ◽  
Cancer Cell ◽  
Therapeutic Target ◽  
Sequence Similarity ◽  
Cancer Cell Lines ◽  
Tumor Proliferation ◽  
Wild Type ◽  
Novel Therapeutic

e23136 Background: We have reported the usefulness of Family with sequence similarity 83, member B (FAM83B) as a novel biomarker for diagnosis and prognosis of lung squamous cell carcinoma. FAM83B expresses not only in lung cancer but also in several types of solid cancer. More recently, novel finding showing FAM83B involve to tumor growth, oncogenesis, and resistance of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) in breast cancer cell lines has been shown. EGFR signaling pathway also plays an important role in lung adenocarcinoma, therefore, we hypothesize that FAM83B associates with tumor proliferation in lung adenocarcinoma (ADC), results in resistance to EGFR-TKI and in a novel therapeutic target in a part of lung ADC. Here we show that correlation between FAM83B expression and clinicopathological features. Methods: This study was conducted with approval of ethics committee in our institute, and informed consent was obtained from all the participants. We identified 216 participants underwent for primary lung ADC between 2008 and 2015. Paired tumor and corresponding normal tissue samples obtained from patients were subjected. FAM83B mRNA expression were examined by cDNA microarray, and analyzed relationship between the level of FAM83B and clinicopathological variables including survival analysis. Further, FAM83B knock down study was performed in several types of cancer cell lines (H1975, HLC-1, H2347) to validate whether FAM83B involve to cell proliferation. Results: FAM83B highly expressed in male (p = 0.007), or smoker (p = 0.007), or EGFR wild type tumor (p<0.001). Multivariate analyses also showed that EGFR wild type-tumor correlate with FAM83B expression. In survival analysis, multivariate analysis showed FAM83B correlated with poor outcome in both disease free survival and overall survival (p = 0.011 and p = 0.001), especially stratified by EGFR wild type-tumor (p = 0.017, p = 0.008). Gene silencing with FAM83B siRNA showed growth suppression of HLC-1 and H1975 cell lines. Conclusions: FAM83B could involve to tumor proliferation of lung ADC in part, and expected to be the novel therapeutic target of EGFR wild type-ADC.

Abstract #619 Primary Lung Adenocarcinoma in a Sea of Metastatic Thyroid Cancer

2019 ◽  
Vol 25 ◽  
pp. 319-320
Author(s):  
Lourdes Rodriguez ◽  
Mary Baker ◽  
Daniel W Karakla ◽  
David Lieb
Keyword(s):  
Thyroid Cancer ◽  
Lung Adenocarcinoma ◽  
Primary Lung Adenocarcinoma ◽  
Metastatic Thyroid Cancer

WNT/TCF Signaling through LEF1 and HOXB9 Mediates Lung Adenocarcinoma Metastasis

2009 ◽  
Vol 138 (1) ◽  
pp. 51-62 ◽  
Author(s):  
Don X. Nguyen ◽  
Anne C. Chiang ◽  
Xiang H.-F. Zhang ◽  
Juliet Y. Kim ◽  
Mark G. Kris ◽  
...  
Keyword(s):  
Lung Adenocarcinoma

Human Chorionic Gonadotropin and CA 15-3 Producing Adenocarcinoma

1998 ◽  
Vol 37 (08) ◽  
pp. 297-298 ◽  
Author(s):  
A. Özet ◽  
A. Arpaci ◽  
S. Kömiircü ◽  
G. Üçkaya
Keyword(s):  
Lung Adenocarcinoma ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Carbohydrate Antigen ◽  
Beta Subunit ◽  
Cancer Antigen ◽  
First Report ◽  
Primary Lung Adenocarcinoma ◽  
Adenocarcinoma Of Lung

Summary50 years old man suffering from primary lung adenocarcinoma presented with high levels of both beta subunit human chorionic gonadotropin (βHCG) and cancer antigen 15-3 (CA 15-3) in the absence of elevated carcinoembrionic antigen (CEA), alfa fetoprotein (AFP) and carbohydrate antigen 19-9 (CA 19-9). Although βHCG or CA 15-3 high levels were reported in adenocarcinoma of lung, this is the first report of a patient with high levels of both markers.

CD26 is overexpressed in lung adenocarcinoma and qualifies as a therapeutic target against lung cancer

2018 ◽  
Author(s):  
N Enz ◽  
F Janker ◽  
F Ramírez Fragoso ◽  
M Haberecker ◽  
A Soltermann ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lung Adenocarcinoma ◽  
Therapeutic Target

A framework for risk stratification in EGFR+ lung adenocarcinoma treated with tyrosine kinase inhibitors

2019 ◽  
Author(s):  
P Christopoulos ◽  
M Kirchner ◽  
F Bozorgmehr ◽  
N Magios ◽  
AL Volckmar ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Tyrosine Kinase ◽  
Lung Adenocarcinoma ◽  
Tyrosine Kinase Inhibitors ◽  
Kinase Inhibitors

Parallel Acquired Resistance Heterogeneity: Novel Patient Derived Synchronous Cell Pair with Distinct Mutations in an ALK-Translocated Lung Adenocarcinoma

2019 ◽  
Author(s):  
Balazs Hegedüs ◽  
Paul Stockhammer ◽  
Till Plönes ◽  
Luca Hegedüs ◽  
Agnes Bankfalvi ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Acquired Resistance ◽  
Cell Pair ◽  
Synchronous Cell
Sign in / Sign up

Export Citation Format

Share Document