scholarly journals Common Genomic Aberrations in Mouse and Human Breast Cancers with Concurrent P53 Deficiency and Activated PTEN-PI3K-AKT Pathway

2022 ◽  
Vol 18 (1) ◽  
pp. 229-241
Author(s):  
Jarrod D. Martinez ◽  
Qianxing Mo ◽  
Yixiang Xu ◽  
Li Qin ◽  
Yi Li ◽  
...  
Keyword(s):  
Akt Pathway ◽  
Breast Cancers ◽  
Human Breast ◽  
Genomic Aberrations

scholarly journals MRCKα Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 942
Author(s):  
Mei Qi Kwa ◽  
Rafael Brandao ◽  
Trong H. Phung ◽  
Jianfeng Ge ◽  
Giuseppe Scieri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression Signature ◽  
Genomic Analysis ◽  
Cancer Development ◽  
Breast Cancer Cell Lines ◽  
Normal Mammary Gland ◽  
Breast Cancers ◽  
Human Breast ◽  
Breast Cancer Development

MRCKα is a ubiquitously expressed serine/threonine kinase involved in cell contraction and F-actin turnover, which is highly amplified in human breast cancer and part of a gene expression signature for bad prognosis. Nothing is known about the in vivo function of MRCKα. To explore MRCKα function in development and in breast cancer, we generated mice lacking a functional MRCKα gene. Mice were born close to the Mendelian ratio and showed no obvious phenotype including a normal mammary gland formation. Assessing breast cancer development using the transgenic MMTV-PyMT mouse model, loss of MRCKα did not affect tumor onset, tumor growth and metastasis formation. Deleting MRCKα and its related family member MRCKβ in two triple-negative breast cancer cell lines resulted in reduced invasion of MDA-MB-231 cells, but did not affect migration of 4T1 cells. Further genomic analysis of human breast cancers revealed that MRCKα is frequently co-amplified with the oncogenes ARID4B and AKT3 which might contribute to the prognostic value of MRCKα expression. Collectively, these data suggest that MRCKα might be a prognostic marker for breast cancer, but probably of limited functional importance.

Analysis of the aromatase cytochrome P450 gene in human breast cancers

1994 ◽  
Vol 13 (3) ◽  
pp. 331-337 ◽  
Author(s):  
P Sourdaine ◽  
M G Parker ◽  
J Telford ◽  
W R Miller
Keyword(s):  
Cytochrome P450 ◽  
Breast Cancers ◽  
Human Breast ◽  
Cytochrome P450 Gene ◽  
P450 Gene

Co-expression of Oct-4 and Nestin in human breast cancers

2011 ◽  
Vol 39 (5) ◽  
pp. 5875-5881 ◽  
Author(s):  
Caigang Liu ◽  
Xuezhao Cao ◽  
Yanjun Zhang ◽  
Hong Xu ◽  
Ruishan Zhang ◽  
...  
Keyword(s):  
Breast Cancers ◽  
Human Breast

Overexpression and enhanced specific activity of aldoketo reductases (AKR1B1 & AKR1B10) in human breast cancers

The Breast ◽  
2017 ◽  
Vol 31 ◽  
pp. 137-143 ◽  
Author(s):  
K. Ashok Reddy ◽  
P. Uday Kumar ◽  
M. Srinivasulu ◽  
B. Triveni ◽  
K. Sharada ◽  
...  
Keyword(s):  
Specific Activity ◽  
Breast Cancers ◽  
Human Breast
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