scholarly journals Cepharanthine inhibits hepatocellular carcinoma cell growth and proliferation by regulating amino acid metabolism and suppresses tumorigenesis in vivo

2021 ◽  
Vol 17 (15) ◽  
pp. 4340-4352
Author(s):  
Fan Feng ◽  
Lianhong Pan ◽  
Jiaqin Wu ◽  
Lanqing Li ◽  
Haiying Xu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Amino Acid ◽  
Cell Growth ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Carcinoma Cell ◽  
Hepatocellular Carcinoma Cell ◽  
Cell Growth And Proliferation

scholarly journals NIMA-related kinase 2 regulates hepatocellular carcinoma cell growth and proliferation

2017 ◽  
Vol 13 (3) ◽  
pp. 1587-1594 ◽  
Author(s):  
Xiao-Bo Lai ◽  
Yu-Qiang Nie ◽  
Hong-Li Huang ◽  
Ying-Fei Li ◽  
Chuang-Yu Cao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Growth ◽  
Carcinoma Cell ◽  
Hepatocellular Carcinoma Cell ◽  
Cell Growth And Proliferation

scholarly journals Chloroquine inhibits hepatocellular carcinoma cell growth in vitro and in vivo

2015 ◽  
Vol 35 (1) ◽  
pp. 43-49 ◽  
Author(s):  
TAO HU ◽  
PEI LI ◽  
ZHONGGUANG LUO ◽  
XIAOYU CHEN ◽  
JINGYANG ZHANG ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Growth ◽  
Carcinoma Cell ◽  
Hepatocellular Carcinoma Cell

scholarly journals Silencing of hypoxia-inducible adrenomedullin using RNA interference attenuates hepatocellular carcinoma cell growth in vivo

2014 ◽  
Vol 10 (3) ◽  
pp. 1295-1302 ◽  
Author(s):  
FENBAO LI ◽  
RUIMIN YANG ◽  
XIZHONG ZHANG ◽  
AIGUANG LIU ◽  
YONGLI ZHAO ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Rna Interference ◽  
Cell Growth ◽  
Carcinoma Cell ◽  
Hepatocellular Carcinoma Cell

scholarly journals Combination of HSV1-TK/shTERT by retrovirus vector inhibits hepatocellular carcinoma cell growth in vitro and in vivo

2014 ◽  
Vol 33 (3) ◽  
pp. 1307-1313 ◽  
Author(s):  
HONGSHENG LI ◽  
QIAOYU WANG ◽  
DONGLI LI ◽  
QUANSHI WANG ◽  
HUBING WU
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Growth ◽  
Carcinoma Cell ◽  
Retrovirus Vector ◽  
Hepatocellular Carcinoma Cell

scholarly journals LncRNA-SNHG6 promotes the progression of hepatocellular carcinoma by targeting miR-6509-5p and HIF1A

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xiaoxi Fan ◽  
Zhongwei Zhao ◽  
Jingjing Song ◽  
Dengke Zhang ◽  
Fazong Wu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Growth ◽  
Bioinformatics Analysis ◽  
Carcinoma Cell ◽  
Noncoding Rnas ◽  
Migration And Invasion ◽  
Carcinoma Cell Lines ◽  
Huh7 Cells ◽  
Hepatocellular Carcinoma Cell

Abstract Background Accumulating evidences have been reported that long noncoding RNAs play crucial roles in the progression of hepatocellular carcinoma (HCC). SnoRNA host gene 6 (SNHG6) is believed to be involved in several human cancers, but the specific molecular mechanism of SNHG6 in HCC is not well studied. Methods In this study, we experimentally down-regulated the SNHG6 in two hepatocellular carcinoma cell lines in vitro, and then measured the proliferation, migration and invasion abilities and the apoptotic levels. Also, we performed the xenograft assay to investigate the function of SNHG6 during the tumor growth in vivo. Results We found SNHG6 was highly expressed in HCC tissues. Next, using Hep3B and Huh7 cells, we confirmed knockdown of SNHG6 reduced the proliferation, migration and invasion abilities in vitro. Also, by bioinformatics analysis, further molecular and cellular experiments, we found miR-6509-5p bound to SNHG6 directly, and the expression level of HIF1A was regulated through SNHG6/miR-6509-5p axis. Finally, we found that down-regulation of SNHG6 dramatically reduced the tumor growth ability of Huh7 cells in vivo. Conclusions We concluded that SNHG6/miR-6509-5p/HIF1A axis functioned in the progression of hepatocellular carcinoma, and could be the promising therapeutic targets during the development of hepatocellular carcinoma drugs.

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