scholarly journals High ovarian GDF-8 levels contribute to elevated estradiol production in ovarian hyperstimulation syndrome by stimulating aromatase expression

2021 ◽  
Vol 17 (9) ◽  
pp. 2338-2347
Author(s):  
Lanlan Fang ◽  
Yang Yan ◽  
Sijia Wang ◽  
Yanjie Guo ◽  
Yiran Li ◽  
...  
Keyword(s):  
Ovarian Hyperstimulation Syndrome ◽  
Ovarian Hyperstimulation ◽  
Aromatase Expression

scholarly journals Melatonin stimulates aromatase expression and estradiol production in human granulosa-lutein cells: relevance for high serum estradiol levels in patients with ovarian hyperstimulation syndrome

2020 ◽  
Vol 52 (8) ◽  
pp. 1341-1350
Author(s):  
Jung-Chien Cheng ◽  
Lanlan Fang ◽  
Yiran Li ◽  
Sijia Wang ◽  
Yuxi Li ◽  
...  
Keyword(s):  
Granulosa Cells ◽  
Follicular Fluid ◽  
Ovarian Hyperstimulation Syndrome ◽  
Elevated Serum ◽  
Ovarian Hyperstimulation ◽  
Serum Estradiol ◽  
Melatonin Receptor ◽  
Aromatase Expression ◽  
Human Granulosa Cells

Abstract Ovarian hyperstimulation syndrome (OHSS) is one of the most life-threatening and potentially fatal complications associated with controlled ovarian hyperstimulation (COH) during in vitro fertilization (IVF) treatment. Although the pathogenesis of OHSS remains unclear, elevated serum estradiol (E2) levels before human chorionic gonadotropin (hCG) administration are associated with the risk of OHSS. The pineal hormone melatonin and its receptors are expressed in human granulosa cells and have been shown to stimulate E2 production. However, the effect of melatonin on the expression of aromatase, an enzyme responsible for a key step in the biosynthesis of E2, in human granulosa cells remains to be determined. Here, we demonstrate that melatonin upregulates aromatase expression in primary cultured human granulosa-lutein (hGL) cells through the melatonin receptor-mediated PKA-CREB pathway. Using a mouse model of OHSS, we demonstrate that administration of the melatonin receptor inhibitor luzindole inhibits the development of OHSS. In addition, the expression of ovarian aromatase and serum E2 levels are upregulated in OHSS mice compared to control mice, but this upregulation is attenuated by inhibition of the function of melatonin. Moreover, clinical results reveal that aromatase expression levels are upregulated in hGL cells from OHSS patients. Melatonin and E2 levels in the follicular fluid are significantly higher in OHSS patients than in non-OHSS patients. Furthermore, melatonin levels are positively correlated with E2 levels in follicular fluid. This study helps to elucidate the mechanisms mediating the expression of aromatase in hGL cells and provides a potential mechanism explaining the high E2 levels in patients with OHSS.

Thrombosis Associated with Ovarian Hyperstimulation Syndrome in a Carrier of the Factor V Leiden Mutation

1996 ◽  
Vol 76 (02) ◽  
pp. 275-277 ◽  
Author(s):  
Sylvie Hollemaert ◽  
Jean-Claude Wautrecht ◽  
Paul Capel ◽  
Marc J Abramowicz ◽  
Yvon Englert ◽  
...  
Keyword(s):  
Ovarian Hyperstimulation Syndrome ◽  
Factor V Leiden ◽  
Ovarian Hyperstimulation ◽  
Factor V ◽  
Factor V Leiden Mutation

Gonadotroph pituitary macroadenoma inducing ovarian hyperstimulation syndrome

2018 ◽  
Author(s):  
Blertina Dyrmishi ◽  
Taulant Olldashi ◽  
Entela Puca ◽  
Ema Lumi ◽  
Dorina Ylli
Keyword(s):  
Ovarian Hyperstimulation Syndrome ◽  
Ovarian Hyperstimulation ◽  
Pituitary Macroadenoma
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