scholarly journals Long noncoding RNA SH3PXD2A-AS1 promotes colorectal cancer progression by regulating p53-mediated gene transcription

2021 ◽  
Vol 17 (8) ◽  
pp. 1979-1994
Author(s):  
Pingfu Hou ◽  
Tian Lin ◽  
Sen Meng ◽  
Meilin Shi ◽  
Fang Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gene Transcription ◽  
Cancer Progression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Colorectal Cancer Progression

Long noncoding RNA CMPK2 promotes colorectal cancer progression by activating the FUBP3–c-Myc axis

Oncogene ◽  
2020 ◽  
Vol 39 (19) ◽  
pp. 3926-3938 ◽  
Author(s):  
Qingzu Gao ◽  
Rui Zhou ◽  
Yuan Meng ◽  
Rongfei Duan ◽  
Ling Wu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Colorectal Cancer Progression

scholarly journals The Long Noncoding RNA HOTAIR Promotes Colorectal Cancer Progression by Sponging miR-197

2018 ◽  
Vol 26 (3) ◽  
pp. 473-481 ◽  
Author(s):  
Xinyang Lu ◽  
Zhiqiang Liu ◽  
Xiaofei Ning ◽  
Lunhua Huang ◽  
Biao Jiang
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Migration And Invasion ◽  
Downstream Target ◽  
Potential Applications ◽  
Colorectal Cancer Progression

The long noncoding RNA HOX transcript antisense RNA (HOTAIR) has been found to be overexpressed in many human malignancies and involved in tumor progression and metastasis. Although the downstream target through which HOTAIR modulates tumor metastasis is not well known, evidence suggests that microRNA-197 (miR-197) might be involved in this event. In the present study, the significance of HOTAIR and miR-197 in the progression of colorectal cancer was detected in vitro and in vivo. We found that HOTAIR expression was significantly increased in colorectal cancer cells and tissues. In contrast, the expression of miR-197 was obviously decreased. We further demonstrated that HOTAIR knockdown promoted apoptosis and inhibited cell proliferation, migration, and invasion in vitro and in vivo. Moreover, HOTAIR modulated the progression of colorectal cancer by competitively binding miR-197. Taken together, our study has identified a novel pathway through which HOTAIR exerts its oncogenic role and provided a molecular basis for potential applications of HOTAIR in the prognosis and treatment of colorectal cancer.

scholarly journals Long noncoding RNA RHPN1-AS1 promotes colorectal cancer progression via targeting miR-7-5p/OGT axis

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Wei Zheng ◽  
Hui Li ◽  
Hui Zhang ◽  
Chao Zhang ◽  
Zhonglin Zhu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Colorectal Cancer Progression

scholarly journals Long Noncoding RNA PCAT18 Upregulates SPRR3 to Promote Colorectal Cancer Progression by Binding to miR-759

2020 ◽  
Vol Volume 12 ◽  
pp. 11445-11452
Author(s):  
Daqing Yang ◽  
Rizeng Li ◽  
Jianfu Xia ◽  
Wencai Li ◽  
Lili Ma ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Colorectal Cancer Progression

Long noncoding RNA TMEM75 promotes colorectal cancer progression by activation of SIM2

Gene ◽  
2018 ◽  
Vol 675 ◽  
pp. 80-87 ◽  
Author(s):  
Xiaoyan Jin ◽  
Guangming Liu ◽  
Xiuna Zhang ◽  
Na Du
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Colorectal Cancer Progression
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