scholarly journals Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis

2020 ◽  
Vol 16 (1) ◽  
pp. 147-161 ◽  
Author(s):  
Nan Zhang ◽  
Fu Peng ◽  
Yujia Wang ◽  
Li Yang ◽  
Fengbo Wu ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Jnk Signaling ◽  
Signaling Axis

scholarly journals Blockade of the LRP16-PKR-NF-κB signaling axis sensitizes colorectal carcinoma cells to DNA-damaging cytotoxic therapy

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Xiaolei Li ◽  
Zhiqiang Wu ◽  
Xiaojing An ◽  
Qian Mei ◽  
Miaomiao Bai ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Nuclear Factor Kappa B ◽  
Carcinoma Cells ◽  
Therapeutic Resistance ◽  
Cytotoxic Therapy ◽  
Double Stranded Rna ◽  
Colon Tumorigenesis ◽  
Dna Damaging Agents ◽  
Signaling Axis ◽  
Dramatic Shift

Acquired therapeutic resistance by tumors is a substantial impediment to reducing the morbidity and mortality that are attributable to human malignancies. The mechanisms responsible for the dramatic shift between chemosensitivity and chemoresistance in colorectal carcinoma have not been defined. Here, we report that LRP16 selectively interacts and activates double-stranded RNA-dependent kinase (PKR), and also acts as scaffolds to assist the formation of a ternary complex of PKR and IKKβ, prolonging the polymers of ADP-ribose (PAR)-dependent nuclear factor kappa B (NF-κB) transactivation caused by DNA-damaging agents and confers acquired chemoresistance. We also identified a small molecule, MRS2578, which strikingly abrogated the binding of LRP16 to PKR and IKKβ, converting LRP16 into a death molecule and forestalling colon tumorigenesis. Inclusion of MRS2578 with etoposide, versus each drug alone, exhibited synergistic antitumor cytotoxicity in xenografts. Our combinatorial approach introduces a strategy to enhance the efficacy of genotoxicity therapies for the treatment of tumors.

scholarly journals Correction: Blockade of the LRP16-PKR-NF-κB signaling axis sensitizes colorectal carcinoma cells to DNA-damaging cytotoxic therapy

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Xiaolei Li ◽  
Zhiqiang Wu ◽  
Xiaojing An ◽  
Qian Mei ◽  
Miaomiao Bai ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Cytotoxic Therapy ◽  
Signaling Axis

Angiotensin IV binding sites on colorectal carcinoma cells

2001 ◽  
Author(s):  
Blanka Železná ◽  
Eva Šloncová ◽  
Dana Kučerová ◽  
Jiřina Slaninová ◽  
Štefan Zorad ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Binding Sites ◽  
Carcinoma Cells ◽  
Angiotensin Iv

scholarly journals β3GnT8 regulates the metastatic potential of colorectal carcinoma cells by altering the glycosylation of CD147

2014 ◽  
Vol 31 (4) ◽  
pp. 1795-1801 ◽  
Author(s):  
JIANLONG NI ◽  
ZHI JIANG ◽  
LI SHEN ◽  
LIPING GAO ◽  
MEIYUN YU ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Metastatic Potential ◽  
Carcinoma Cells
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