scholarly journals Feedback Activation of SGK3 and AKT Contributes to Rapamycin Resistance by Reactivating mTORC1/4EBP1 Axis via TSC2 in Breast Cancer

2019 ◽  
Vol 15 (5) ◽  
pp. 929-941 ◽  
Author(s):  
Hongtao Wang ◽  
Fang Huang ◽  
Zhe Zhang ◽  
Peng Wang ◽  
Yuan Luo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Rapamycin Resistance ◽  
Feedback Activation

Abstract A90: Feedback activation of EGFR drives resistance to BRAF(V600E) inhibition in breast cancer.

2013 ◽  
Author(s):  
Yj Yang ◽  
HJ Na ◽  
Ws Kim ◽  
JP Bong ◽  
SJ Beak ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Braf V600e ◽  
Feedback Activation

Upregulation of Akt/Raptor signaling is associated with rapamycin resistance of breast cancer cells

2020 ◽  
Vol 330 ◽  
pp. 109243 ◽  
Author(s):  
Yuri Shchegolev ◽  
Danila Sorokin ◽  
Alexander Scherbakov ◽  
Alexey Shunaev ◽  
Olga Andreeva ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Rapamycin Resistance

scholarly journals Arsenic Trioxide Overcomes Rapamycin-Induced Feedback Activation of AKT and ERK Signaling to Enhance the Anti-Tumor Effects in Breast Cancer

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e85995 ◽  
Author(s):  
Cynthia Guilbert ◽  
Matthew G. Annis ◽  
Zhifeng Dong ◽  
Peter M. Siegel ◽  
Wilson H. Miller ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Arsenic Trioxide ◽  
Erk Signaling ◽  
Feedback Activation

scholarly journals Estrogen receptor alpha drives mTORC1 inhibitor-induced feedback activation of PI3K/AKT in ER+ breast cancer

Oncotarget ◽  
2018 ◽  
Vol 9 (10) ◽  
pp. 8810-8822 ◽  
Author(s):  
Wei Yang ◽  
Gary N. Schwartz ◽  
Jonathan D. Marotti ◽  
Vivian Chen ◽  
Nicole A. Traphagen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha ◽  
Feedback Activation

Virus-Like Particles in a Human Breast Cancer: Structural Similarity to Previously Reported Particles

1973 ◽  
Vol 31 ◽  
pp. 378-379
Author(s):  
G. Kasnic ◽  
S. E. Stewart ◽  
C. Urbanski
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Human Breast Cancer ◽  
Osteogenic Sarcoma ◽  
Human Tumor ◽  
Structural Similarity ◽  
Cell Tumor ◽  
Human Breast ◽  
Human Tumor Cell ◽  
Type Particle

We have reported the maturation of an intracisternal A-type particle in murine plasma cell tumor cultures and three human tumor cell cultures (rhabdomyosarcoma, lung adenocarcinoma, and osteogenic sarcoma) after IUDR-DMSO activation. In all of these studies the A-type particle seems to develop into a form with an electron dense nucleoid, presumably mature, which is also intracisternal. A similar intracisternal A-type particle has been described in leukemic guinea pigs. Although no biological activity has yet been demonstrated for these particles, on morphologic grounds, and by the manner in which they develop within the cell, they may represent members of the same family of viruses.

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