scholarly journals Fibroblast Growth Factor 21 Attenuates Vascular Calcification by Alleviating Endoplasmic Reticulum Stress Mediated Apoptosis in Rats

2019 ◽  
Vol 15 (1) ◽  
pp. 138-147 ◽  
Author(s):  
Yuchen Shi ◽  
Shaoping Wang ◽  
Hongyu Peng ◽  
Yuan Lv ◽  
Wenzheng Li ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Growth Factor ◽  
Endoplasmic Reticulum Stress ◽  
Fibroblast Growth Factor ◽  
Vascular Calcification ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth

scholarly journals Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress–Fibroblast Growth Factor 21 Axis in Skeletal Muscle

Diabetes ◽  
2018 ◽  
Vol 67 (4) ◽  
pp. 594-606 ◽  
Author(s):  
Magdalene K. Montgomery ◽  
Ruzaidi Mokhtar ◽  
Jacqueline Bayliss ◽  
Helena C. Parkington ◽  
Victor M. Suturin ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Endoplasmic Reticulum ◽  
Growth Factor ◽  
Endoplasmic Reticulum Stress ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Perilipin 5

Fibroblast growth factor 21 is induced by endoplasmic reticulum stress

Biochimie ◽  
2013 ◽  
Vol 95 (4) ◽  
pp. 692-699 ◽  
Author(s):  
Frank G. Schaap ◽  
Andreas E. Kremer ◽  
Wouter H. Lamers ◽  
Peter L.M. Jansen ◽  
Ingrid C. Gaemers
Keyword(s):  
Endoplasmic Reticulum ◽  
Growth Factor ◽  
Endoplasmic Reticulum Stress ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth

scholarly journals Fibroblast Growth Factor 21 Predicts and Promotes Vascular Calcification in Haemodialysis Patients

2020 ◽  
Author(s):  
Liqiong Jiang ◽  
Qing Yin ◽  
Min Yang ◽  
Min Li ◽  
Mingming Pan ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Thoracic Aorta ◽  
Vascular Calcification ◽  
Calcium Deposition ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Mineral Density ◽  
Mesenchymal Transition

Abstract Background: Cardiovascular disease (CVD) is the leading cause of death in haemodialysis (HD) patients. Vascular calcification (VC) is dramatically accelerated and is strongly associated with CVD events and mortality in HD patients. VC coexists with osteoporosis in many studies. Fibroblast growth factor 21 (FGF21) as an adipocytokines is a new hypoglycemic strategy and is inversely related to bone mineral density.Methods: To evaluate the contribution of FGF21 to VC in HD patients, we preliminary sreened 802 HD patients of two large HD centers in China. At last 388 HD patients were entered this cross-sectional study. We detected circulating FGF21 levels and measured the whole thoracic aorta calcification scores (TACS) and calcification scores of the three segments of thoracic aorta (TA), including ascending thoracic aorta (ATACS), aortic arch (AoACS), and descending thoracic aorta (DTACS) of our 388 HD patients. In addition, we pre-incubated human aortic endothelial cells (HAECs) with FGF21 in the presence or absence of parathyroid hormone (PTH) in vitro.Results: The median serum FGF21 level in HD patients was 11-fold higher than that in healthy controls. Ln(FGF21) was positively correlated with Ln(TACS+1), Ln(ATACS+1), Ln(AoACS+1) and Ln(DTACS+1) respectively in HD patients. Serum FGF21 was independently associated with TACS and ATACS, AoACS, and DTACS. FGF21 combined with age, calcium and intact parathyroid hormone demonstrated a high area under the curve (AUC=0.84) with optimal sensitivity (84%) and specificity (71%) for the prediction of VC in HD patients. Our vitro results showed that FGF21 enhanced the calcification effect of PTH on HAECs by increasing calcium deposition and endothelial-to-mesenchymal transition (EndMT).Conclusions: Circulating FGF21 was notably higher and was a potential predictor and promoter of VC in HD patients.Trial registration Chinese Clinical Trial Registry, identifier: ChiCTR1900028249. Registered 16 December 2019-Retrospectively registered,http://www.medresman.org.cn/uc/project/projectedit.aspx?proj=5981

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