scholarly journals Topical Application of Tat-Rac1 Promotes Cutaneous Wound Healing in Normal and Diabetic Mice

2018 ◽  
Vol 14 (10) ◽  
pp. 1163-1174
Author(s):  
Bin Fan ◽  
Tao Wang ◽  
Li Bian ◽  
Zhe Jian ◽  
Dongyan D. Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Topical Application ◽  
Cutaneous Wound Healing ◽  
Diabetic Mice ◽  
Cutaneous Wound

scholarly journals Sodium Butyrate Plus EGF and PDGF-BB Aids Cutaneous Wound Healing in Diabetic Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-10
Author(s):  
Rohini Keshava ◽  
Rajalakshmi Gope
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Topical Application ◽  
Sodium Butyrate ◽  
Diabetic Patients ◽  
Cutaneous Wound Healing ◽  
Diabetic Mice ◽  
Tissue Samples ◽  
Cutaneous Wound ◽  
Diabetic Wounds

Topical application of growth factors is known to aid defective and/or delayed wound healing in diabetic patients. In this study, the effect of topical application of sodium butyrate (Na-Bu), EGF, and PDGF-BB was analysed on the acute cutaneous wound healing in streptozotocin (STZ) induced diabetic mouse model. Two cutaneous wounds were created, one on each of the dorsolateral sides of the diabetic mice. Na-Bu, EGF, and PDGF-BB were applied to the wound either individually or in various combinations. The wound healing was monitored visually and scored as percentage wound closure. The tissue samples were collected from the wound site at 1, 7, and 14 days after wounding from the treated and untreated diabetic wounds and analysed for the levels of EGF-R, β-PDGF-R, HDAC1, p21, and phosphorylated and hypophosphorylated pRb proteins. Our results indicate that application of EGF plus PDGF-BB at the initial stages followed by subsequent addition of Na-Bu along with these growth factors helps wound healing in diabetic mice. It appears that, in addition to cell proliferative agents, a cell differentiation agent, Na-Bu, is necessary for diabetic wound healing. Topical application of EGF plus PDGF-BB along with Na-Bu could be developed as therapeutic agents to treat and manage human diabetic wounds.

scholarly journals Comparison of EGF with VEGF Non-Viral Gene Therapy for Cutaneous Wound Healing of Streptozotocin Diabetic Mice

2011 ◽  
Vol 35 (3) ◽  
pp. 226 ◽  
Author(s):  
Junghae Ko ◽  
Haejung Jun ◽  
Hyesook Chung ◽  
Changshin Yoon ◽  
Taekyoon Kim ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Wound Healing ◽  
Viral Gene ◽  
Cutaneous Wound Healing ◽  
Diabetic Mice ◽  
Cutaneous Wound ◽  
Viral Gene Therapy

Topical application of omega-3-, omega-6-, and omega-9-rich oil emulsions for cutaneous wound healing in rats

2018 ◽  
Vol 9 (2) ◽  
pp. 418-433 ◽  
Author(s):  
Wan Maznah Wan Ishak ◽  
Haliza Katas ◽  
Ng Pei Yuen ◽  
Maizaton Atmadini Abdullah ◽  
Mohd Hanif Zulfakar
Keyword(s):  
Wound Healing ◽  
Topical Application ◽  
Cutaneous Wound Healing ◽  
Omega 3 ◽  
Cutaneous Wound ◽  
Omega 6 ◽  
3 Omega ◽  
Oil Emulsions

Topical application of metformin accelerates cutaneous wound healing in streptozotocin-induced diabetic rats

2021 ◽  
Author(s):  
Fatma Kubra Tombulturk ◽  
Zeynep Gizem Todurga-Seven ◽  
Onder Huseyinbas ◽  
Sibel Ozyazgan ◽  
Turgut Ulutin ◽  
...  
Keyword(s):  
Wound Healing ◽  
Topical Application ◽  
Diabetic Rats ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound

Topical application of dressing with amino acids improves cutaneous wound healing in aged rats

2010 ◽  
Vol 112 (5) ◽  
pp. 497-507 ◽  
Author(s):  
Giovanni Corsetti ◽  
Giuseppe D’Antona ◽  
Francesco Saverio Dioguardi ◽  
Rita Rezzani
Keyword(s):  
Amino Acids ◽  
Wound Healing ◽  
Topical Application ◽  
Cutaneous Wound Healing ◽  
Aged Rats ◽  
Cutaneous Wound

Topical application of Acalypha indica accelerates rat cutaneous wound healing by up-regulating the expression of Type I and III collagen

2012 ◽  
Vol 142 (1) ◽  
pp. 14-22 ◽  
Author(s):  
Moorthy Ganeshkumar ◽  
Thangavel Ponrasu ◽  
Rajesh Krithika ◽  
Kuttalam Iyappan ◽  
Vinaya Subramani Gayathri ◽  
...  
Keyword(s):  
Wound Healing ◽  
Topical Application ◽  
Type I ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Acalypha Indica
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