scholarly journals Crosstalk between Mitochondrial Fission and Oxidative Stress in Paraquat-Induced Apoptosis in Mouse Alveolar Type II Cells

2017 ◽  
Vol 13 (7) ◽  
pp. 888-900 ◽  
Author(s):  
Guangju Zhao ◽  
Kaiqiang Cao ◽  
Changqin Xu ◽  
Aifang Sun ◽  
Wang Lu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Fission ◽  
Alveolar Type ◽  
Type Ii Cells ◽  
Type Ii ◽  
Alveolar Type Ii Cells ◽  
Induced Apoptosis ◽  
And Oxidative Stress

Lysosomal and mitochondrial pathways in H2O2-induced apoptosis of alveolar type II cells

2004 ◽  
Vol 94 (3) ◽  
pp. 433-445 ◽  
Author(s):  
Lei Yin ◽  
Rebecca Stearns ◽  
Beatriz González-Flecha
Keyword(s):  
Alveolar Type ◽  
Type Ii Cells ◽  
Type Ii ◽  
Alveolar Type Ii Cells ◽  
Induced Apoptosis

scholarly journals Chronic-Alcohol-Abuse-Induced Oxidative Stress in the Development of Acute Respiratory Distress Syndrome

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Yan Liang ◽  
Samantha M. Yeligar ◽  
Lou Ann S. Brown
Keyword(s):  
Oxidative Stress ◽  
Distress Syndrome ◽  
Alcohol Ingestion ◽  
Alveolar Type ◽  
Type Ii Cells ◽  
Type Ii ◽  
Chronic Alcohol ◽  
Alveolar Type Ii Cells ◽  
Alveolar Epithelial ◽  
Chronic Alcohol Ingestion

Chronic alcohol ingestion increases the risk of developing acute respiratory distress syndrome (ARDS), a severe form of acute lung injury, characterized by alveolar epithelial and endothelial barrier disruption and intense inflammation. Alcohol abuse is also associated with a higher incidence of sepsis or pneumonia resulting in a higher rate of admittance to intensive care, longer inpatient stays, higher healthcare costs, and a 2–4 times greater mortality rate. Chronic alcohol ingestion induced severe oxidative stress associated with increased ROS generation, depletion of the critical antioxidant glutathione (GSH), and oxidation of the thiol/disulfide redox potential in the alveolar epithelial lining fluid and exhaled breath condensate. Across intracellular and extracellular GSH pools in alveolar type II cells and alveolar macrophages, chronic alcohol ingestion consistently induced a 40–60 mV oxidation of GSH/GSSG suggesting that the redox potentials of different alveolar GSH pools are in equilibrium. Alcohol-induced GSH depletion or oxidation was associated with impaired functions of alveolar type II cells and alveolar macrophages but could be reversed by restoring GSH pools in the alveolar lining fluid. The aims of this paper are to address the mechanisms for alcohol-induced GSH depletion and oxidation and the subsequent effects in alveolar barrier integrity, modulation of the immune response, and apoptosis.

Giant Lamellar Bodies in Alveolar Type II Cells of Rats Exposed to a Low Concentration of Ozone

Respiration ◽  
1984 ◽  
Vol 46 (3) ◽  
pp. 303-309 ◽  
Author(s):  
Sanae Shimura ◽  
Shinsaku Maeda ◽  
Tamotsu Takismima
Keyword(s):  
Alveolar Type ◽  
Type Ii Cells ◽  
Type Ii ◽  
Lamellar Bodies ◽  
Alveolar Type Ii Cells ◽  
Low Concentration
Sign in / Sign up

Export Citation Format

Share Document