scholarly journals Molecular evolution of the histone variant H2A.Z

2019 ◽  
Vol 35 (3) ◽  
pp. 217-218
Author(s):  
S. Kitagawa ◽  
M. Kusakabe ◽  
H. Oku ◽  
D. Takahashi ◽  
T. Narimiya ◽  
...  
Keyword(s):  
Molecular Evolution ◽  
Histone Variant

Analysis of the molecular evolution of histone variant H2A.Z using a linker-mediated complex strategy and yeast genetic complementation

2021 ◽  
Author(s):  
Saho Kitagawa ◽  
Masayuki Kusakabe ◽  
Daisuke Takahashi ◽  
Takumi Narimiya ◽  
Yu Nakabayashi ◽  
...  
Keyword(s):  
Molecular Evolution ◽  
Evolutionary Conservation ◽  
Histone Variant ◽  
Genetic Complementation ◽  
Yeast Genetic

Abstract The histone variant H2A.Z is deposited into chromatin by specific machinery and is required for genome functions. Using a linker-mediated complex strategy combined with yeast genetic complementation, we demonstrate evolutionary conservation of H2A.Z together with its chromatin incorporation and functions. This approach is applicable to the evolutionary analyses of proteins that form complexes with interactors.

Molecular evolution of a cytochrome P450 for the synthesis of potential antidepressant (2R,6R)-hydroxynorketamine

2021 ◽  
Author(s):  
Ansgar Bokel ◽  
Michael C. Hutter ◽  
Vlada B. Urlacher
Keyword(s):  
Cytochrome P450 ◽  
Molecular Evolution ◽  
Cytochrome P450 Monooxygenase ◽  
P450 Monooxygenase ◽  
Effective Synthesis

Engineered cytochrome P450 monooxygenase CYP154E1 enables the effective synthesis of the potential antidepressant (2R,6R)-hydroxynorketamine via N-demethylation and regio- and stereoselective hydroxylation of (R)-ketamine.

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