scholarly journals ITSN protein family: regulation of diversity, role in signalling and pathology

2013 ◽  
Vol 29 (3) ◽  
pp. 244-251 ◽  
Author(s):  
L. O. Tsyba ◽  
M. V. Dergai ◽  
I. Ya. Skrypkina ◽  
O. V. Nikolaienko ◽  
O. V. Dergai ◽  
...  
Keyword(s):  
Protein Family ◽  
Family Regulation

scholarly journals Annexin/S100A Protein Family Regulation through p14ARF-p53 Activation: A Role in Cell Survival and Predicting Treatment Outcomes in Breast Cancer

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0169925 ◽  
Author(s):  
Diana Hatoum ◽  
Daniel Yagoub ◽  
Alireza Ahadi ◽  
Najah T. Nassif ◽  
Eileen M. McGowan
Keyword(s):  
Breast Cancer ◽  
Cell Survival ◽  
Treatment Outcomes ◽  
Protein Family ◽  
P53 Activation ◽  
Family Regulation

scholarly journals Homer protein family regulation in skeletal muscle and neuromuscular adaptation

IUBMB Life ◽  
2013 ◽  
Vol 65 (9) ◽  
pp. 769-776 ◽  
Author(s):  
Michele Salanova ◽  
Pompeo Volpe ◽  
Dieter Blottner
Keyword(s):  
Skeletal Muscle ◽  
Protein Family ◽  
Neuromuscular Adaptation ◽  
Homer Protein ◽  
Family Regulation

Investigating the functional link between TMEM165 and SPCA1

2019 ◽  
Vol 476 (21) ◽  
pp. 3281-3293 ◽  
Author(s):  
Elodie Lebredonchel ◽  
Marine Houdou ◽  
Hans-Heinrich Hoffmann ◽  
Kateryna Kondratska ◽  
Marie-Ange Krzewinski ◽  
...  
Keyword(s):  
Subcellular Localization ◽  
Complete Loss ◽  
Protein Family ◽  
Uncharacterized Protein ◽  
Functional Link ◽  
P Type

TMEM165 was highlighted in 2012 as the first member of the Uncharacterized Protein Family 0016 (UPF0016) related to human glycosylation diseases. Defects in TMEM165 are associated with strong Golgi glycosylation abnormalities. Our previous work has shown that TMEM165 rapidly degrades with supraphysiological manganese supplementation. In this paper, we establish a functional link between TMEM165 and SPCA1, the Golgi Ca2+/Mn2+ P-type ATPase pump. A nearly complete loss of TMEM165 was observed in SPCA1-deficient Hap1 cells. We demonstrate that TMEM165 was constitutively degraded in lysosomes in the absence of SPCA1. Complementation studies showed that TMEM165 abundance was directly dependent on SPCA1's function and more specifically its capacity to pump Mn2+ from the cytosol into the Golgi lumen. Among SPCA1 mutants that differentially impair Mn2+ and Ca2+ transport, only the Q747A mutant that favors Mn2+ pumping rescues the abundance and Golgi subcellular localization of TMEM165. Interestingly, the overexpression of SERCA2b also rescues the expression of TMEM165. Finally, this paper highlights that TMEM165 expression is linked to the function of SPCA1.

The involvement of the GGA protein family in BACE transport and APP processing in Alzheimer's disease

2008 ◽  
Vol 35 (S 01) ◽  
Author(s):  
C Steinmetz ◽  
B von Einem ◽  
D Schwanzar ◽  
F Dolp ◽  
A.C Ludolph ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Protein Family ◽  
App Processing
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