scholarly journals Possibility of Diagnosing Uterine Function in Cows

2016 ◽  
Vol 50 (2) ◽  
pp. 115-119 ◽  
Author(s):  
Kosuke IGA ◽  
Naoki TAKENOUCHI ◽  
Manabu SHIMIZU ◽  
Yuji HIRAO
Keyword(s):  
Uterine Function

Fetal development of in vitro-produced embryos: Possible association with uterine function

2000 ◽  
Vol 77 (E-Suppl) ◽  
pp. 1 ◽  
Author(s):  
C. E. Farin ◽  
P. W. Farin ◽  
P. Blondin ◽  
A. E. Crosier
Keyword(s):  
Fetal Development ◽  
Uterine Function

Uterine Function: From Normal to Polycystic Ovarian Syndrome Alterations

2018 ◽  
Vol 25 (15) ◽  
pp. 1792-1804 ◽  
Author(s):  
Silvana R. Ferreira ◽  
Alicia B. Motta
Keyword(s):  
Endometrial Cancer ◽  
Adhesion Molecules ◽  
Polycystic Ovarian Syndrome ◽  
Cellular Proliferation ◽  
Steroid Receptors ◽  
Reproductive Age ◽  
Present Review ◽  
Implantation Failure ◽  
Uterine Function ◽  
Ovarian Syndrome

Background: The endometrium is one of the most important female reproductive organs. Polycystic ovarian syndrome (PCOS) is a reproductive and endocrine pathology that affect women of reproductive age. PCOS negatively affects the endometrium, leading to implantation failure and proliferative aberrations. Methods: We conducted a search at the http://www.ncbi.nlm.nhi.gov/pubmed/electronic database using the following key words: endometrial steroid receptors, endometrium, uterine function, endometrium and PCOS, implantation window, implantation and PCOS, implantation markers, inflammation, oxidative stress. We selected the articles based on their titles and abstracts, then we analyzed the full text and classified the articles depending on the information provided according to the sections of the present review. Results: The endocrine and metabolic abnormalities displayed in women with PCOS promote complex effects on the endometrium, leading to a low rate of implantation and even infertility. Women with PCOS show alterations in the Hypothalamic-Pituitary- Ovarian axis, which results in constant circulating levels of estrogen, similar to those at the early follicular phase, and a deficiency in the withdrawal of estrogen and progesterone. Besides this deficiency in the withdrawal of estrogen and progesterone, the insulin/ glucose pathway, adhesion molecules, cytokines and the inflammatory cascade, together with the establishment of a pro-oxidative status, lead to an imbalance in the uterine function, which in turn leads to implantation failure or even endometrial cancer. Conclusion: Women with PCOS display a dysregulation of the Hypothalamic-Pituitary- Ovarian axis, which alters the steroid pathway. In addition, the deficiency in the withdrawal of estrogen and progesterone in the endometrium results in abnormal endometrial cellular proliferation. The imbalance in adipose tissue observed in PCOS patients reinforces the increase in circulating hormones. The present review describes the role of hormones, metabolites, cytokines, adhesion molecules and the insulin/glucose pathway related to the uterine endometrium in women with PCOS and their role in implantation failure and development of endometrial cancer.

scholarly journals Forkhead box a2 (FOXA2) is essential for uterine function and fertility

2017 ◽  
Vol 114 (6) ◽  
pp. E1018-E1026 ◽  
Author(s):  
Andrew M. Kelleher ◽  
Wang Peng ◽  
James K. Pru ◽  
Cindy A. Pru ◽  
Francesco J. DeMayo ◽  
...  
Keyword(s):  
Stromal Cell ◽  
Adult Mouse ◽  
Embryo Implantation ◽  
Critical Event ◽  
Mouse Uterus ◽  
Forkhead Box ◽  
Uterine Gland ◽  
Blastocyst Implantation ◽  
Uterine Function ◽  
Uterine Glands

Establishment of pregnancy is a critical event, and failure of embryo implantation and stromal decidualization in the uterus contribute to significant numbers of pregnancy losses in women. Glands of the uterus are essential for establishment of pregnancy in mice and likely in humans. Forkhead box a2 (FOXA2) is a transcription factor expressed specifically in the glands of the uterus and is a critical regulator of postnatal uterine gland differentiation in mice. In this study, we conditionally deleted FOXA2 in the adult mouse uterus using the lactotransferrin Cre (Ltf-Cre) model and in the neonatal mouse uterus using the progesterone receptor Cre (Pgr-Cre) model. The uteri of adult FOXA2-deleted mice were morphologically normal and contained glands, whereas the uteri of neonatal FOXA2-deleted mice were completely aglandular. Notably, adult FOXA2-deleted mice are completely infertile because of defects in blastocyst implantation and stromal cell decidualization. Leukemia inhibitory factor (LIF), a critical implantation factor of uterine gland origin, was not expressed during early pregnancy in adult FOXA2-deleted mice. Intriguingly, i.p. injections of LIF initiated blastocyst implantation in the uteri of both gland-containing and glandless adult FOXA2-deleted mice. Although pregnancy was rescued by LIF and was maintained to term in uterine gland-containing adult FOXA2-deleted mice, pregnancy failed by day 10 in neonatal FOXA2-deleted mice lacking uterine glands. These studies reveal a previously unrecognized role for FOXA2 in regulation of adult uterine function and fertility and provide original evidence that uterine glands and, by inference, their secretions play important roles in blastocyst implantation and stromal cell decidualization.

scholarly journals Oxytocin and Uterine Function in Pregnant and Parturient Rats

1970 ◽  
Vol 2 (3) ◽  
pp. 387-400 ◽  
Author(s):  
Anna-Riitta Fuchs ◽  
Vicente F. Poblete
Keyword(s):  
Uterine Function

scholarly journals Membrane protein CD9 is repositioned and released to enhance uterine function

2018 ◽  
Vol 99 (2) ◽  
pp. 200-209 ◽  
Author(s):  
Maki Iwai ◽  
Toshio Hamatani ◽  
Akihiro Nakamura ◽  
Natsuko Kawano ◽  
Seiya Kanai ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Uterine Function

Regulatory Peptides and Uterine Function

1990 ◽  
pp. 393-422 ◽  
Author(s):  
Bent Ottesen ◽  
Jan Fahrenkrug
Keyword(s):  
Regulatory Peptides ◽  
Uterine Function

PROSTAGLANDINS AND UTERINE FUNCTION

Prostanoids ◽  
1980 ◽  
pp. 161-166
Author(s):  
G. Jėcsai ◽  
S. Bagdány ◽  
B. Tanács ◽  
I. Birtalan ◽  
I. Rákóczi ◽  
...  
Keyword(s):  
Uterine Function

The influence of uterine function on embryonic and fetal survival

2002 ◽  
Vol 80 (E-suppl_2) ◽  
pp. E115-E125 ◽  
Author(s):  
J. L. Vallet ◽  
K. A. Leymaster ◽  
R. K. Christenson
Keyword(s):  
Fetal Survival ◽  
Uterine Function
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