scholarly journals Genome-Scale Technology Driven Advances to Research into Normal and Malignant Haematopoiesis

Scientifica ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-11
Author(s):  
Berthold Göttgens
Keyword(s):  
Cell Biology ◽  
New Technologies ◽  
Adult Stem Cell ◽  
Chip Sequencing ◽  
Diagnosis And Prognosis ◽  
Research Fields ◽  
Current State ◽  
Cancer Genome Sequencing ◽  
Large Numbers ◽  
Genome Scale

Haematopoiesis or blood development has long served as a model system for adult stem cell biology. Moreover, when combined, the various cancers of the blood represent one of the commonest human malignancies. Large numbers of researchers have therefore dedicated their scientific careers to studying haematopoiesis for more than a century. Throughout this period, many new technologies have first been applied towards the study of blood cells, and the research fields of normal and malignant haematopoiesis have also been some of the earliest adopters of genome-scale technologies. This has resulted in significant new insights with implications ranging from basic biological mechanisms to patient diagnosis and prognosis and also produced lessons likely to be relevant for many other areas of biomedical research. This paper discusses the current state of play for a range of genome-scale applications within haemopoiesis research, including gene expression profiling, ChIP-sequencing, genomewide association analysis, and cancer genome sequencing. A concluding outlook section explores likely future areas of progress as well as potential technological and educational bottlenecks.

scholarly journals A short guide to technology development in cell biology

2015 ◽  
Vol 208 (6) ◽  
pp. 655-657 ◽  
Author(s):  
Bas van Steensel
Keyword(s):  
Technological Innovation ◽  
Cell Biology ◽  
New Technologies ◽  
Technology Development ◽  
New Technology ◽  
Development Project ◽  
Successful Outcome ◽  
Bottom Up ◽  
Research Fields ◽  
Technology Development Project

New technologies drive progress in many research fields, including cell biology. Much of technological innovation comes from “bottom-up” efforts by individual students and postdocs. However, technology development can be challenging, and a successful outcome depends on many factors. This article outlines some considerations that are important when embarking on a technology development project. Despite the challenges, developing a new technology can be extremely rewarding and could lead to a lasting impact in a given field.

scholarly journals The Current State of Sensing, Health Management, and Control for Small-to-Medium-Sized Manufacturers

2016 ◽  
Author(s):  
Moneer Helu ◽  
Brian Weiss
Keyword(s):  
Case Studies ◽  
New Technologies ◽  
Health Management ◽  
Shop Floor ◽  
Manufacturing Operations ◽  
Diagnosis And Prognosis ◽  
Industrial Sectors ◽  
Current State ◽  
Medium Enterprises ◽  
And Control

The development of digital technologies for manufacturing has been challenged by the difficulty of navigating the breadth of new technologies available to industry. This difficulty is compounded by technologies developed without a good understanding of the capabilities and limitations of the manufacturing environment, especially within small-to-medium enterprises (SMEs). This paper describes industrial case studies conducted to identify the needs, priorities, and constraints of manufacturing SMEs in the areas of performance measurement, condition monitoring, diagnosis, and prognosis. These case studies focused on contract and original equipment manufacturers with less than 500 employees from several industrial sectors. Solution and equipment providers and National Institute of Standards and Technology (NIST) Hollings Manufacturing Extension Partnership (MEP) centers were also included. Each case study involved discussions with key shop-floor personnel as well as site visits with some participants. The case studies highlight SME’s strong need for access to appropriate data to better understand and plan manufacturing operations. They also help define industrially-relevant use cases in several areas of manufacturing operations, including scheduling support, maintenance planning, resource budgeting, and workforce augmentation.

Introduction

2018 ◽  
Author(s):  
Tim Lewens
Keyword(s):  
Social Sciences ◽  
Human Nature ◽  
Potential Functions ◽  
Human Psychology ◽  
Human Culture ◽  
The Third ◽  
Current State ◽  
Large Numbers ◽  
The Social ◽  
Compare And Contrast

Many evolutionary theorists have enthusiastically embraced human nature, but large numbers of evolutionists have also rejected it. It is also important to recognize the nuanced views on human nature that come from the side of the social sciences. This introduction provides an overview of the current state of the human nature debate, from the anti-essentialist consensus to the possibility of a Gray’s Anatomy of human psychology. Three potential functions for the notion of species nature are identified. The first is diagnostic, assigning an organism to the correct species. The second is species-comparative, allowing us to compare and contrast different species. The third function is contrastive, establishing human nature as a foil for human culture. The Introduction concludes with a brief synopsis of each chapter.

Analysis of Aluminium Beam-to-Column Joints by the Component Method: Existing Studies and Research Needs

2016 ◽  
Vol 710 ◽  
pp. 409-414 ◽  
Author(s):  
Gianfranco De Matteis ◽  
Giuseppe Brando
Keyword(s):  
Current Knowledge ◽  
Component Method ◽  
The Past ◽  
Research Fields ◽  
Numerical Studies ◽  
Current State ◽  
Moment Resisting ◽  
New Research ◽  
Steel Joints

This paper aims at providing an overview on the current state of the art and on possible future developments concerning the component method implementation for the classification of beam-to-column joints belonging to aluminum moment resisting frames.After a brief discussion on the component method theoretical bases, developed in the past to give a feasible calculation procedure for steel joints, recent experimental and numerical studies, carried out for investigating some aluminum components, are presented and discussed. In particular strengths and weaknesses of the current knowledge are put into evidence, also in light of the peculiarities that make aluminum alloys different from steel. The launch of new research fields, aimed at pursuing an update of the current codes dealing with aluminum structures, is therefore proposed.

MIC-Drop: A platform for large-scale in vivo CRISPR screens

Science ◽  
2021 ◽  
pp. eabi8870
Author(s):  
Saba Parvez ◽  
Chelsea Herdman ◽  
Manu Beerens ◽  
Korak Chakraborti ◽  
Zachary P. Harmer ◽  
...  
Keyword(s):  
Large Scale ◽  
Cultured Cells ◽  
Cardiac Development ◽  
Droplet Microfluidics ◽  
Model Organisms ◽  
Genetic Screens ◽  
Large Numbers ◽  
And Function ◽  
Genome Scale

CRISPR-Cas9 can be scaled up for large-scale screens in cultured cells, but CRISPR screens in animals have been challenging because generating, validating, and keeping track of large numbers of mutant animals is prohibitive. Here, we report Multiplexed Intermixed CRISPR Droplets (MIC-Drop), a platform combining droplet microfluidics, single-needle en masse CRISPR ribonucleoprotein injections, and DNA barcoding to enable large-scale functional genetic screens in zebrafish. The platform can efficiently identify genes responsible for morphological or behavioral phenotypes. In one application, we show MIC-Drop can identify small molecule targets. Furthermore, in a MIC-Drop screen of 188 poorly characterized genes, we discover several genes important for cardiac development and function. With the potential to scale to thousands of genes, MIC-Drop enables genome-scale reverse-genetic screens in model organisms.

scholarly journals Inflammatory Regulation of Valvular Remodeling: The Good(?), the Bad, and the Ugly

2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Gretchen J. Mahler ◽  
Jonathan T. Butcher
Keyword(s):  
Heart Valve ◽  
Cell Biology ◽  
Heart Valves ◽  
Valve Disease ◽  
Heart Valve Disease ◽  
Inflammatory Signaling ◽  
Current State ◽  
Valve Remodeling ◽  
Inflammatory Regulation ◽  
Key Questions

Heart valve disease is unique in that it affects both the very young and very old, and does not discriminate by financial affluence, social stratus, or global location. Research over the past decade has transformed our understanding of heart valve cell biology, yet still more remains unclear regarding how these cells respond and adapt to their local microenvironment. Recent studies have identified inflammatory signaling at nearly every point in the life cycle of heart valves, yet its role at each stage is unclear. While the vast majority of evidence points to inflammation as mediating pathological valve remodeling and eventual destruction, some studies suggest inflammation may provide key signals guiding transient adaptive remodeling. Though the mechanisms are far from clear, inflammatory signaling may be a previously unrecognized ally in the quest for controlled rapid tissue remodeling, a key requirement for regenerative medicine approaches for heart valve disease. This paper summarizes the current state of knowledge regarding inflammatory mediation of heart valve remodeling and suggests key questions moving forward.

scholarly journals Challenges of digitalization and artificial intelligence for modern economies, societies and management

2020 ◽  
Vol 28 (3) ◽  
pp. 556-567
Author(s):  
Rolf Clauberg
Keyword(s):  
Artificial Intelligence ◽  
New Technologies ◽  
Technical Information ◽  
Developed Countries ◽  
Negative Effects ◽  
Physical Systems ◽  
Large Numbers ◽  
Official Policy ◽  
The Usa ◽  
New Jobs

This study aims at identifying the challenges of digitalization and artificial intelligence for modern economies, societies and business administration. The implementation of digitalization schemes as Industry 4.0 are presently official policy of many developed countries. The goal is optimization of production processes and supply chains. Artificial intelligence is also affecting many fields. Both technologies are expected to substantially change working conditions for many people. It is important to identify the kind and impact of these changes and possible means to minimize negative effects. For this purpose, this study uses previous results about the disappearance of manufacturing jobs in the USA and their impact on different groups of society together with technical information about the new technologies to deduce expected changes caused by digitalization and artificial intelligence. Results are that both technologies will destroy large numbers of jobs and complete job classes while at the same time creating new jobs very different from the ones destroyed. Extensive permanent education and re-education of employees will be necessary to minimize negative effects, probably even changes to a more broad-based education to improve the potential of job changes into completely new fields. In addition, the technical information about digitalization in cyber-physical systems points to dangers that will require solutions on the international level.

scholarly journals Chitosan Applications on Pharmaceutical Sciences: A Review

2019 ◽  
Vol 9 (3) ◽  
pp. 167-181
Author(s):  
Cintia Alejandra Briones Nieva ◽  
Mercedes Villegas ◽  
Alicia Graciela Cid ◽  
Analía Irma Romero ◽  
José María Bermúdez
Keyword(s):  
New Technologies ◽  
Immunological Response ◽  
Biological Properties ◽  
Future Research ◽  
Pharmaceutical Sciences ◽  
Chemical Derivatization ◽  
Current State ◽  
Pharmaceutical Applications ◽  
Novel Applications ◽  
State Of Art

Background: Chitosan (CS) is a biomaterial derived from chitin, known for its excellent biological properties. One of the most interesting features of CS is its potential for chemical derivatization, which makes it a versatile material and allows to expand its applications. In the last years, the interest on this polymer and its pharmaceutical applications has notably increased. This biopolymer is being widely studied for its interesting properties, such as bioadhesion, antimicrobial activity, biocompatibility, and biodegradability. Other promising properties of CS include its modulation of immunological response, hemostasis, and wound and bone healing activity. Objective: In this work, a critical review is performed covering its conventional and novel applications, specially focused on pharmaceutical area, providing a clear picture of the current state of art to serve as a basis to direct future research in this field. Conclusion: Despite all the qualities of this polymer, there are only few CS-based products in the market, so it is a priority to enhance the research to develop new technologies and CS-based systems to enforce this biopolymer in the industry.

CURRENT STATE OF ELECTRONIC BANKING SERVICES IN THE INTERNATIONAL TECHNOLOGY MARKET AND WAYS TO IMPROVE THEM

2020 ◽  
Vol 4 (11) ◽  
pp. 107-113
Author(s):  
Z. K. DZHAFAROVA ◽  
◽  
Z. ASADULAEVA ◽  
Keyword(s):  
Banking Sector ◽  
New Technologies ◽  
Electronic Banking ◽  
Banking Services ◽  
Current State ◽  
Technology Market

The article examines the features and changes of banking services in connection with the use of new technologies in the banking sector, with the transition to more convenient payment platforms, with the con-nection of electronic banking. The problems faced by banks are identified and ways to solve them are recom-mended.

The undergraduate dissertation as a reflection of education for sustainability and professional identity: the faculty of education of Bilbao

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Nahia Idoiaga Mondragon ◽  
Inge Axpe Saez ◽  
Ainhoa Berciano
Keyword(s):  
Language Learning ◽  
Professional Identity ◽  
New Technologies ◽  
Relevant Information ◽  
Education For Sustainability ◽  
Educational Transformation ◽  
Content Type ◽  
Current State ◽  
Faculty Of Education ◽  
Sustainable Developmental Goals

Purpose The undergraduate dissertation (UD) can be considered to be a reflection of the influence of the sustainable developmental goals (SDG) and the professional identity of the students. The purpose of this paper is to analyse the extent to which the topics of the UD reflect the SDG, considering, moreover, that they may be related to the professional identity developed by the students throughout the degree. Design/methodology/approach This work researches the topic of 308 UDs graded as “Excellent” in the Faculty of Education of Bilbao (FEB), using a lexical analysis method. Findings The results show two main branches: one associated with Childhood and Social Education Degrees (related to gender equality and socio-educational transformation); and another linked to the Primary Education Degree (language learning, innovation and new technologies). These analyses show the influence of the 5th (40.8%) and 4th (38.4%) SDGs in the topics chosen for the UDs. Research limitations/implications The findings provide valuable insights into the current state of Education for Sustainable Development in the Faculty, but should be complemented with an analysis of the topics of all the UDs, to have a more real vision of the situation. Originality/value This study analyses, for the first time, the topics of the UDs from the perspective of sustainability, taking into account the dissertations that reach a standard of excellence in the FEB. These results provide relevant information that can be very helpful to detect the specific needs for the design and implementation of an awareness-raising action that will lead to working on sustainability in a transversal way in the education degrees of the FEB.

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