scholarly journals In vivo characteristics of premixed calcium phosphate cements when implanted in subcutaneous tissues and periodontal bone defects

2010 ◽  
Vol 115 (4) ◽  
pp. 277 ◽  
Author(s):  
Akiyoshi Sugawara ◽  
Kenji Fujikawa ◽  
Satoshi Hirayama ◽  
Shozo Takagi ◽  
Laurence C. Chow
Keyword(s):  
Calcium Phosphate ◽  
Bone Defects ◽  
Calcium Phosphate Cements ◽  
Subcutaneous Tissues ◽  
Periodontal Bone Defects

Therapy and regeneration-combined bone cements for minimally invasive treatment of neoplastic bone defects

2021 ◽  
Author(s):  
Yu Qu ◽  
Hui Zhuang ◽  
Meng Zhang ◽  
Yufeng Wang ◽  
Dong Zhai ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Minimally Invasive ◽  
Tumor Cells ◽  
Bone Tumor ◽  
Tumor Resection ◽  
Bone Defects ◽  
Bone Cements ◽  
Invasive Treatment ◽  
Calcium Phosphate Cements ◽  
Bone Tumor Resection

Although calcium phosphate cements (CPC) have been clinically used to repair bone defects caused by bone tumor resection, traditional CPC cannot kill the remaining tumor cells after surgery and prevent...

scholarly journals Biocompatibility and Bone Formation of Flexible, Cotton Wool-like PLGA/Calcium Phosphate Nanocomposites in Sheep

2011 ◽  
Vol 5 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Oliver D Schneider ◽  
Dirk Mohn ◽  
Roland Fuhrer ◽  
Karina Klein ◽  
Käthi Kämpf ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Antimicrobial Properties ◽  
Drill Hole ◽  
Bone Defects ◽  
Long Bone ◽  
Minimal Amount ◽  
Cotton Wool

Background: The purpose of this preliminary study was to assess the in vivo performance of synthetic, cotton wool-like nanocomposites consisting of a biodegradable poly(lactide-co-glycolide) fibrous matrix and containing either calcium phosphate nanoparticles (PLGA/CaP 60:40) or silver doped CaP nanoparticles (PLGA/Ag-CaP 60:40). Besides its extraordinary in vitro bioactivity the latter biomaterial (0.4 wt% total silver concentration) provides additional antimicrobial properties for treating bone defects exposed to microorganisms. Materials and Methods: Both flexible artificial bone substitutes were implanted into totally 16 epiphyseal and metaphyseal drill hole defects of long bone in sheep and followed for 8 weeks. Histological and histomorphological analyses were conducted to evaluate the biocompatibility and bone formation applying a score system. The influence of silver on the in vivo performance was further investigated. Results: Semi-quantitative evaluation of histology sections showed for both implant materials an excellent biocompatibility and bone healing with no resorption in the adjacent bone. No signs of inflammation were detectable, either macroscopically or microscopically, as was evident in 5 µm plastic sections by the minimal amount of inflammatory cells. The fibrous biomaterials enabled bone formation directly in the centre of the former defect. The area fraction of new bone formation as determined histomorphometrically after 8 weeks implantation was very similar with 20.5 ± 11.2 % and 22.5 ± 9.2 % for PLGA/CaP and PLGA/Ag-CaP, respectively. Conclusions: The cotton wool-like bone substitute material is easily applicable, biocompatible and might be beneficial in minimal invasive surgery for treating bone defects.

Processing and in vivo evaluation of multiphasic calcium phosphate cements with dual tricalcium phosphate phases

2012 ◽  
Vol 8 (9) ◽  
pp. 3500-3508 ◽  
Author(s):  
Marco A. Lopez-Heredia ◽  
Matilde Bongio ◽  
Marc Bohner ◽  
Vincent Cuijpers ◽  
Louis A.J.A. Winnubst ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
In Vivo Evaluation ◽  
Calcium Phosphate Cements

scholarly journals Preliminary in Vivo Evaluation of Bone Healing in Critical Size Bone Defects Implanted with an Injectable Calcium Phosphate Bone Cement (Osteopaste)

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Che Nor Zarida Che Seman ◽  
Zamzuri Zakaria ◽  
Zunariah Buyong ◽  
Mohd Shukrimi Awang ◽  
Ahmad Razali Md Ralib @ Md Raghib
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Bone Tissue ◽  
Bone Repair ◽  
Critical Size ◽  
Healing Process ◽  
Bone Defects ◽  
Calcium Phosphate Bone Cement ◽  
Rabbit Tibia

Introduction: A novel injectable calcium phosphate bone cement (osteopaste) has been developed. Its potential application in orthopaedics as a filler of bone defects has been studied. The biomaterial was composed of tetra-calcium phosphate (TTCP) and tricalcium phosphate (TCP) powder. The aim of the present study was to evaluate the healing process of osteopaste in rabbit tibia. Materials and method: The implantation procedure was carried out on thirty-nine of New Zealand white rabbits. The in vivo bone formation was investigated by either implanting the Osteopaste, Jectos or MIIG – X3 into a critical size defect (CSD) model in the proximal tibial metaphysis. CSD without treatment served as negative control. After 1 day, 6 and 12 weeks, the rabbits were euthanized, the bone were harvested and subjected for analysis. Results: Radiological images and histological sections revealed integration of implants with bone tissue with no signs of graft rejection. There was direct contact between osteopaste material and host bone. The new bone was seen bridging the defect. Conclusion: The result showed that Osteopaste could be a new promising biomaterial for bone repair and has a potential in bone tissue engineering.

scholarly journals Injectable calcium phosphate cements loaded with local analgesics: Design and preliminary �in vivo� results

2016 ◽  
Vol 4 ◽  
Author(s):  
Janvier Pascal ◽  
Masson Martial ◽  
Verron Elise ◽  
Dupleichs Manon ◽  
Pichault Aylwin ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Calcium Phosphate Cements ◽  
Local Analgesics

In vivo behavior of three different injectable hydraulic calcium phosphate cements

Biomaterials ◽  
2004 ◽  
Vol 25 (7-8) ◽  
pp. 1439-1451 ◽  
Author(s):  
D. Apelt ◽  
F. Theiss ◽  
A.O. El-Warrak ◽  
K. Zlinszky ◽  
R. Bettschart-Wolfisberger ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Calcium Phosphate Cements

In Vivo Biological Behavior of Calcium Phosphate Cements with Different Ca/P Ratio

2008 ◽  
Vol 396-398 ◽  
pp. 237-240
Author(s):  
Sybele Saska ◽  
N.S. Nunes ◽  
Emelly Aveiro ◽  
Cristina A.C. Pavan ◽  
S.H. Santagneli ◽  
...  
Keyword(s):  
Thermogravimetric Analysis ◽  
31P Nmr ◽  
Phosphate Buffer Solution ◽  
Biological Behavior ◽  
X Ray Diffraction ◽  
Buffer Solution ◽  
X Ray ◽  
Calcium Phosphate Cements ◽  
Subcutaneous Tissues

Bioceramics with different Ca/P ratio were prepared from a mechanical mixture of NaPO3, CaCO3, Ca(OH)2 and phosphate buffer solution and implanted in rats subcutaneous tissues. The cements were characterized by Thermogravimetric analysis (TG-TDA), X-ray diffraction and 31P-NMR. The implant sites were excised after 1, 4 and 16 weeks, fixed, dehydrated, included in paraffin wax for serial cutting and examined under the light transmitted microscope. They were biocompatible and biodegradable when implanted in rat subcutaneous. None of the materials induced ectopic osteogenesis. According to the results, the studied materials seem to be able for manufacturing reabsorbable bone implants.

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