scholarly journals Efficient Synthetic Approaches to Uric Acid Transporter 1 Inhibitors Bearing Alkoxyl Group-Substituted Triazoles

2017 ◽  
Vol 37 (7) ◽  
pp. 1748
Author(s):  
He Tian ◽  
Jingwei Wu ◽  
Yuqiang Liu ◽  
Yafei Xie ◽  
Jianwu Wang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Alkoxyl Group ◽  
Acid Transporter ◽  
Synthetic Approaches

Mechanism of Traditional Medicine Tongfeng Li’an Granules on Hyperuricemic Rats Based on Regulating Uric Acid Transporter

2021 ◽  
Vol 15 (4) ◽  
pp. 536-541
Author(s):  
Xiangpei Zhao ◽  
Li Li ◽  
Chuanmei Zhong ◽  
Hongli Teng ◽  
Guodong Huang
Keyword(s):  
Uric Acid ◽  
Oral Administration ◽  
Natural Product ◽  
Serum Uric Acid ◽  
Rat Model ◽  
Regulatory Mechanism ◽  
High Dose ◽  
Model Group ◽  
Serum Biochemical ◽  
Acid Transporter

Hyperuricemia (HUA) is a metabolic disorder of purine metabolism which leads to the increase of serum uric acid. Tongfeng Lian granule (TFLA) is a clinical empirical traditional herb prescription in China, is biobased natural product material. To study its regulatory mechanism on uric acid transporter in rats with HUA, the rat model of hyperuricemic was established by oral administration of potassium oxazinate (1.5 g/kg) and adenine (0.05 g/kg). The related indexes were detected to evaluate the uric Acid Transporter after treat with TFLA. In the results, compared with model group, the high dose TFLA can reduce the levels of Related serum biochemical indexes (*P < 0.05, **P < 0.01). TFLA could reduce the levels of URAT1, GLUT9 and increase the expression of OAT3 in kidney. In conclusion, TFLA can effectively inhibit the level of serum uric acid with hyperuricemia rats, and the possible mechanism related to TFLA inhibiting the reabsorption of uric acid by URAT1 and GLUT9, promoting the secretion of OAT3 and uric acid into urine.

scholarly journals Overexpression of Uric Acid Transporter SLC2A9 Inhibits Proliferation of Hepatocellular Carcinoma Cells

2019 ◽  
Vol 27 (5) ◽  
pp. 533-540 ◽  
Author(s):  
Xiaoying Han ◽  
Jing Yang ◽  
Dong Li ◽  
Zewei Guo
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Uric Acid ◽  
Tumor Suppressor ◽  
Cell Apoptosis ◽  
Suppressor Gene ◽  
Potential Contribution ◽  
Acid Transporter ◽  
Underlying Mechanisms ◽  
Hcc Cells

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated mortality worldwide. Although the mechanisms of HCC progression are not well understood, recent studies demonstrated the potential contribution of uric acid transporter SLC2A9 to tumor suppression. However, the roles and underlying mechanisms are still unknown. We aimed to study the roles and mechanisms of SLC2A9 in HCC. The present study showed that SLC2A9 expression was decreased in human HCC tissues and cell lines. In addition, overexpression of SLC2A9 inhibited HCC cell proliferation. SCL2A9 induced HCC cell apoptosis by inhibiting the expression of caspase 3. Our study also revealed that upregulation of SLC2A9 reduced intracellular reactive oxygen species (ROS) accumulation. Furthermore, SLC2A9 increased the mRNA and protein expression of tumor suppressor p53 in HCC cells. Probenecid inhibits SLC2A9-mediated uric acid transport, which promotes cell proliferation, inhibits cell apoptosis, induces intracellular ROS, and decreases the expression of p53 in HCC cells. Therefore, the present study demonstrated that SLC2A9 may be a novel tumor suppressor gene and a potential therapeutic target in HCC.

Synthesis and evaluation of sulfonamide derivatives as potent Human Uric Acid Transporter 1 (hURAT1) inhibitors

2017 ◽  
Vol 27 (9) ◽  
pp. 1919-1922
Author(s):  
Xintuo Yang ◽  
Xuehai Pang ◽  
Lei Fan ◽  
Xinghai Li ◽  
Yuanwei Chen
Keyword(s):  
Uric Acid ◽  
Acid Transporter

Placental uric acid transporter GLUT9 is modulated by free iodine

Placenta ◽  
2014 ◽  
Vol 35 (9) ◽  
pp. A97
Author(s):  
Benjamin P. Lüscher ◽  
Michael Fine ◽  
Camilla Marini ◽  
Benjamin Clemençon ◽  
Christiane Albrecht ◽  
...  
Keyword(s):  
Uric Acid ◽  
Free Iodine ◽  
Acid Transporter

ASSOCIATION STUDY OF URIC ACID TRANSPORTER GLUT9 GENOTYPE WITH THE RENIN-ANGIOTENSIN SYSTEM

2018 ◽  
Vol 36 (Supplement 1) ◽  
pp. e76
Author(s):  
T. Konoshita ◽  
M. Urabe ◽  
S. Kaeriyama ◽  
T. Nakaya ◽  
M. Yamada ◽  
...  
Keyword(s):  
Uric Acid ◽  
Association Study ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Acid Transporter
Sign in / Sign up

Export Citation Format

Share Document