scholarly journals Recent Advance of Amino-acids and Their Derivatives as Chiral Ligands in Asymmetric Transfer Hydrogenation of Ketones

2012 ◽  
Vol 32 (1) ◽  
pp. 19 ◽  
Author(s):  
Xiaona Li ◽  
Pengliang Zhang ◽  
Kai Duan ◽  
Jiaxi Wang
Keyword(s):  
Amino Acids ◽  
Transfer Hydrogenation ◽  
Chiral Ligands ◽  
Asymmetric Transfer Hydrogenation

scholarly journals Design of Iridium N-Heterocyclic Carbene Amino Acid Catalysts for Asymmetric Transfer Hydrogenation of Aryl Ketones

Catalysts ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 671
Author(s):  
Chad M. Bernier ◽  
Joseph S. Merola
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Enantiomeric Excess ◽  
Transfer Hydrogenation ◽  
Acid Catalysts ◽  
Asymmetric Transfer Hydrogenation ◽  
Reaction Conditions ◽  
Chiral Complexes ◽  
Acetophenone Derivatives ◽  
Aryl Ketones

A series of chiral complexes of the form Ir(NHC)2(aa)(H)(X) (NHC = N-heterocyclic carbene, aa = chelated amino acid, X = halide) was synthesized by oxidative addition of -amino acids to iridium(I) bis-NHC compounds and screened for asymmetric transfer hydrogenation of ketones. Following optimization of the reaction conditions, NHC, and amino acid ligands, high enantioselectivity was achieved when employing the Ir(IMe)2(l-Pro)(H)(I) catalyst (IMe = 1,3-dimethylimidazol-2-ylidene), which asymmetrically reduces a range of acetophenone derivatives in up to 95% enantiomeric excess.

Asymmetric transfer hydrogenation: chiral ligands and applications

2006 ◽  
Vol 35 (3) ◽  
pp. 226-236 ◽  
Author(s):  
Serafino Gladiali ◽  
Elisabetta Alberico
Keyword(s):  
Transfer Hydrogenation ◽  
Chiral Ligands ◽  
Asymmetric Transfer Hydrogenation

Asymmetric transfer hydrogenation of γ-aryl α,γ-dioxo-butyric acid esters

RSC Advances ◽  
2016 ◽  
Vol 6 (39) ◽  
pp. 33126-33131 ◽  
Author(s):  
Yuan-Zhao Mo ◽  
Hui-Fang Nie ◽  
Yang Lei ◽  
Dong-Xu Zhang ◽  
Xiao-Ye Li ◽  
...  
Keyword(s):  
Butyric Acid ◽  
Carbonyl Compounds ◽  
Transfer Hydrogenation ◽  
Chiral Ligands ◽  
Asymmetric Transfer Hydrogenation ◽  
Acid Esters

Six ferrocene-based chiral ligands were prepared and applied in ATH reaction of multiple-carbonyl compounds as RuCl(p-cymene)[Ts-DPEN] did.

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