Collaborative Approach to Managing a 47-Year-Old Male with Stage IIB Rectosigmoid Colon Cancer and New Onset of Diabetes

Author(s):  
Betsy Dokken, PhD, RN, ANP ◽  
Sandra E. Kurtin, RN, MS, AOCN®, ANP-C
2013 ◽  
Vol 12 (2) ◽  
pp. 103-105
Author(s):  
M. H. Hnatiuk ◽  
Yu. P. Petruk ◽  
M. V. Lianskorunskyi ◽  
S. I. Raichuk ◽  
S. Yu. Shevchenko ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yukimura Higashiura ◽  
Masato Furuhashi ◽  
Marenao Tanaka ◽  
Satoko Takahashi ◽  
Masayuki Koyama ◽  
...  

AbstractFatty liver index (FLI), a predictor of nonalcoholic fatty liver disease, has been reported to be associated with several metabolic disorders. This study aimed to evaluate the relationship between FLI and new onset of diabetes mellitus (DM). We investigated the association of FLI with new onset of DM during a 10-year period in subjects who received annual health examinations (n = 28,990). After exclusion of subjects with DM at baseline and those with missing data, a total of 12,290 subjects (male/female: 7925/4365) who received health examinations were recruited. FLI was significantly higher in males than in females. During the 10-year period, DM was developed in 533 males (6.7%) and 128 females (2.9%). Multivariable Cox proportional hazard models with a restricted cubic spline showed that the risk of new onset of DM increased with a higher FLI at baseline in both sexes after adjustment of age, fasting plasma glucose, habits of alcohol drinking and current smoking, family history of DM and diagnosis of hypertension and dyslipidemia at baseline. When the subjects were divided into subgroups according to tertiles of FLI level at baseline (T1–T3) in the absence and presence of impaired fasting glucose (IFG), hazard ratios after adjustment of the confounders gradually increased from T1 to T3 and from the absence to presence of IFG in both male and female subjects. In conclusion, a high level of FLI predicts new onset of DM in a general population of both male and female individuals.


2019 ◽  
Vol 114 (1) ◽  
pp. S1650-S1650
Author(s):  
Emmanuel McDonald ◽  
Jamie L. Skrove ◽  
Javier Sobrado ◽  
Karthik Mohan
Keyword(s):  

2019 ◽  
Vol 12 ◽  
pp. 117955141882503
Author(s):  
Vikas Jhawat ◽  
Sumeet Gupta ◽  
Bimal K Agarwal ◽  
Partha Roy ◽  
Vipin Saini

Background: Antihypertensive drug therapies have been reported to be associated with new onset of type 2 diabetes mellitus in some hypertensive patients after prolonged use. Angiotensin converting enzyme (ACE) gene has been found to affect essential hypertension, response of antihypertensive therapies, and glycemic disturbances. Therefore, ACE gene I/D polymorphism may be associated with risk of new onset of type 2 diabetes via metabolic disturbances, glycemic dysregulation, and insulin resistance. Aim: To assess the correlation between ACE gene I/D polymorphism and glycemic disturbance under influence of diuretic and other antihypertensive drug therapies. Materials and methods: We recruited 270 normotensive patients as control (150 men and 120 women), 270 hypertensive patients (95 men and 175 women), and 240 hypertensive with new onset of diabetes patients (80 men and 160 women). All samples were genotyped for ACE gene polymorphic alleles and relationship between different genotypes and anthropometric and clinical parameters along with drug therapies was established and analyzed. Results: Baseline clinical (systolic blood pressure, diastolic blood pressure, and fasting blood glucose level) and anthropometric parameters (height, weight, waist circumference, hip circumference, waist-hip ratio, and body mass index) of study populations were found highly statistically significant ( P < .05) when compared among study groups. Furthermore, genotype wise comparison of all these parameters in essential hypertensive (EH) and essential hypertensive with onset of diabetes (EHNOD) patients found most of them nonsignificant and no variation was found with respect to different genotypes of ACE gene. The genotype wise comparison of clinical parameters among different antihypertensive drug therapy was found statistically nonsignificant in both EH and EHNOD patients. Discussion: Anthropometric parameters can be taken as the risk indicator factors for hypertension and diabetes. However, ACE gene polymorphism may not be a risk factor for development of diabetes in hypertensive patients. Conclusion: The present study suggested that ACE gene polymorphism did not show any significant association with the risk of new onset of diabetes in EH patients and more detailed studies with large population size are needed. [Formula: see text]


2012 ◽  
Vol 27 (9) ◽  
pp. 1215-1222 ◽  
Author(s):  
Satoshi Ogiso ◽  
Takashi Yamaguchi ◽  
Meiki Fukuda ◽  
Takahide Murakami ◽  
Yoshihisa Okuchi ◽  
...  

2011 ◽  
Vol 92 (2) ◽  
pp. 203-209 ◽  
Author(s):  
Dorien M. Zelle ◽  
Pramod K. Agarwal ◽  
Jessica L. Pinto Ramirez ◽  
Jaap J. Homan van der Heide ◽  
Eva Corpeleijn ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document