In Situ Normothermic Regional Perfusion for Liver Donation From China Category III (Organ Donation After Brain Death Followed by Circulatory Death): A Single-Center Cohort Study

2020 ◽  
Vol 18 (1) ◽  
pp. 83-88
Author(s):  
Guang-Yu Ding ◽  
Yun Zhao ◽  
Wei Wu ◽  
Ming Zhong ◽  
Pei-Yao Fu ◽  
...  
Keyword(s):  
Cohort Study ◽  
Brain Death ◽  
Organ Donation ◽  
Regional Perfusion ◽  
Single Center ◽  
Donation After Brain Death ◽  
Liver Donation ◽  
Normothermic Regional Perfusion ◽  
Circulatory Death

scholarly journals Successful preservation and transplant of warm ischaemic lungs from controlled donors after circulatory death by prolonged in situ ventilation during normothermic regional perfusion of abdominal organs

2019 ◽  
Vol 29 (5) ◽  
pp. 699-705 ◽  
Author(s):  
Alessandro Palleschi ◽  
Davide Tosi ◽  
Lorenzo Rosso ◽  
Alberto Zanella ◽  
Riccardo De Carlis ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Organ Procurement ◽  
Regional Perfusion ◽  
Low Flow ◽  
Ex Vivo Lung Perfusion ◽  
Abdominal Organs ◽  
Using Data ◽  
Normothermic Regional Perfusion ◽  
Circulatory Death

Abstract OBJECTIVES Donation after circulatory death (DCD) potentially provides transplantable lungs suitable for a transplant, but in Italy, the need for 20 min of a no-touch period after cardiac arrest for legal declaration of death poses real challenges to organ preservation. METHODS This is a single-institution, retrospective study using data collected prospectively between October and December 2017. After the approval of the multidisciplinary DCD study group of Regione Lombardia, Maastricht category III DCD donors became eligible for combined procurement of lungs and abdominal organs. Our group subsequently established a dedicated technical protocol. Our protocol consists of a non-rapid normothermic open-lung procurement process that takes place during abdominal normothermic regional perfusion, namely without pleural topical cooling before the start of pneumoplegia. After the lung is procured according to the technique described in the article, lung function is evaluated by ex vivo lung perfusion, which is run with the low-flow, open atrium, low haematocrit technique. RESULTS During the study, we managed 5 controlled DCDs. In 3 cases, the lungs were successfully transplanted. All 3 patients are alive after 1 year, with good respiratory function. CONCLUSIONS Our approach resulted in adequate lung preservation and successful transplants without detrimental effects on abdominal organ procurement, confirming the possibility of overcoming the obstacle of a long no-touch period in a DCD setting.

Graft utilization after normothermic regional perfusion in controlled donation after circulatory death—a single‐center perspective from France

2021 ◽  
Vol 34 (9) ◽  
pp. 1656-1666
Author(s):  
Xavier Muller ◽  
Guillaume Rossignol ◽  
Sophie Damotte ◽  
Arnaud Gregoire ◽  
Xavier Matillon ◽  
...  
Keyword(s):  
Regional Perfusion ◽  
Donation After Circulatory Death ◽  
Single Center ◽  
Normothermic Regional Perfusion ◽  
Circulatory Death
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