Histologic and Biomechanical Studies of Tendon-To-Bone Healing After Autologous and Allogeneic Bone Transplants

2013 ◽  
Vol 11 (2) ◽  
pp. 164-168
Author(s):  
Ming-Wei Li ◽  
◽  
Xin-She Zhou
Keyword(s):  
Bone Healing ◽  
Allogeneic Bone ◽  
Bone Transplants

scholarly journals A partially demineralized allogeneic bone graft: in vitro osteogenic potential and preclinical evaluation in two different intramembranous bone healing models

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Pierre Tournier ◽  
Jérôme Guicheux ◽  
Arnaud Paré ◽  
Aymeric Maltezeanu ◽  
Thibaut Blondy ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Regeneration ◽  
Bone Healing ◽  
Bone Grafts ◽  
Ease Of Use ◽  
Osteogenic Potential ◽  
Allogeneic Bone ◽  
Promising Alternative ◽  
Allogenic Bone

AbstractIn skeletal surgical procedures, bone regeneration in irregular and hard-to-reach areas may present clinical challenges. In order to overcome the limitations of traditional autologous bone grafts and bone substitutes, an extrudable and easy-to-handle innovative partially demineralized allogenic bone graft in the form of a paste has been developed. In this study, the regenerative potential of this paste was assessed and compared to its clinically used precursor form allogenic bone particles. Compared to the particular bone graft, the bone paste allowed better attachment of human mesenchymal stromal cells and their commitment towards the osteoblastic lineage, and it induced a pro-regenerative phenotype of human monocytes/macrophages. The bone paste also supported bone healing in vivo in a guide bone regeneration model and, more interestingly, exhibited a substantial bone-forming ability when implanted in a critical-size defect model in rat calvaria. Thus, these findings indicate that this novel partially demineralized allogeneic bone paste that combines substantial bone healing properties and rapid and ease-of-use may be a promising alternative to allogeneic bone grafts for bone regeneration in several clinical contexts of oral and maxillofacial bone grafting.

Melatonin as a Trigger of Therapeutic Bone Regenerating Capacity in Biomaterials

2021 ◽  
Vol 22 ◽  
Author(s):  
Jinming Huang ◽  
Yi Li ◽  
Chengqi He
Keyword(s):  
Beneficial Effect ◽  
Bone Regeneration ◽  
Bone Metabolism ◽  
Bone Healing ◽  
Bone Grafting ◽  
Molecular Mechanisms ◽  
Bone Grafts ◽  
Bone Defects ◽  
Allogeneic Bone ◽  
Beneficial Effects

: Bone defects are usually treated with bone grafting. Several synthetic biomaterials have emerged to replace autologous and allogeneic bone grafts, but there are still shortcomings in bone regeneration. Melatonin has demonstrated a beneficial effect on bone metabolism with the potential to treat fractures, bone defects, and osteoporosis. The hormone promoted osteogenesis, inhibited osteoclastogenesis, stimulated angiogenesis, and reduced peri-implantitis around the graft. Recently, a growing number of studies showed beneficial effects of melatonin to treat bone defects. However, cellular and molecular mechanisms involved in bone healing are still poorly understood. In this review, we recapitulate the potential mechanisms of melatonin, providing a new horizon to the clinical treatment of bone defects.

scholarly journals An Extrudable Partially Demineralized Allogeneic Bone Paste Exhibits a Similar Bone Healing Capacity as the “Gold Standard” Bone Graft

2021 ◽  
Vol 9 ◽  
Author(s):  
Pierre Tournier ◽  
Jérôme Guicheux ◽  
Arnaud Paré ◽  
Joëlle Veziers ◽  
Ana Barbeito ◽  
...  
Keyword(s):  
Bone Healing ◽  
Gold Standard ◽  
Bone Grafting ◽  
Critical Size ◽  
Bone Grafts ◽  
Allogeneic Bone ◽  
Clinical Model ◽  
Critical Size Defects ◽  
Grafting Technique

Autologous bone grafts (BGs) remain the reference grafting technique in various clinical contexts of bone grafting procedures despite their numerous peri- and post-operative limitations. The use of allogeneic bone is a viable option for overcoming these limitations, as it is reliable and it has been widely utilized in various forms for decades. However, the lack of versatility of conventional allogeneic BGs (e.g., blocks, powders) limits their potential for use with irregular or hard-to-reach bone defects. In this context, a ready- and easy-to-use partially demineralized allogeneic BG in a paste form has been developed, with the aim of facilitating such bone grafting procedures. The regenerative properties of this bone paste (BP) was assessed and compared to that of a syngeneic BG in a pre-clinical model of intramembranous bone healing in critical size defects in rat calvaria. The microcomputed tridimensional quantifications and the histological observations at 7 weeks after the implantation revealed that the in vivo bone regeneration of critical-size defects (CSDs) filled with the BP was similar to syngeneic bone grafts (BGs). Thus, this ready-to-use, injectable, and moldable partially demineralized allogeneic BP, displaying equivalent bone healing capacity than the “gold standard,” may be of particular clinical relevance in the context of oral and maxillofacial bone reconstructions.

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