scholarly journals The use of negative-pressure wound therapy over a cultured epithelial autograft for full-thickness wounds secondary to purpura fulminans in an infant

2020 ◽  
Author(s):  
Benjamin Kah Liang Goh ◽  
Alvin Wen Choong Chua ◽  
Khong Yik Chew ◽  
Gavin Chun-Wui Kang ◽  
Li-Wei Chiang ◽  
...  
Keyword(s):  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Purpura Fulminans ◽  
Full Thickness ◽  
Wound Therapy ◽  
Cultured Epithelial Autograft

Negative pressure wound therapy using polyvinyl alcohol foam to bolster full-thickness mesh skin grafts in dogs

2017 ◽  
Vol 46 (3) ◽  
pp. 389-395 ◽  
Author(s):  
Matan Or ◽  
Bart Van Goethem ◽  
Adriaan Kitshoff ◽  
Annika Koenraadt ◽  
Ilona Schwarzkopf ◽  
...  
Keyword(s):  
Polyvinyl Alcohol ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Skin Grafts ◽  
Full Thickness ◽  
Wound Therapy

scholarly journals Clinical outcomes of full thickness skin graft combined with negative pressure wound therapy in diabetes mellitus foot amputee after infection

2017 ◽  
Vol 2 (3) ◽  
pp. 2473011417S0000
Author(s):  
Ji-Yong Ahn
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Skin Graft ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Full Thickness ◽  
Full Thickness Skin Graft ◽  
Wound Therapy ◽  
Full Thickness Skin ◽  
Thickness Skin

Category: Diabetes Introduction/Purpose: Infected diabetes mellitus (DM) foot has been controlled with amputation. After performing the amputation with preserving enough length of the foot due to functional and cosmetic advantages, remaining wounds have been covered with split thickness skin graft (STSG) despite of sacrifice of donor site with pain and scar. We hypothesized outcomes of full thickness skin graft (FTSG) combined with negative pressure wound therapy (NPWT) can be an alternative STSG. The aim of this study was to investigate clinical outcomes of FTSG combined with negative pressure wound therapy in DM foot infection. Methods: This study included 21 patients of infected DM foot (21 feet). There were 20 cases of midfoot and 1 case of hindfoot. We performed the amputation and combined NPWT at a mean age of 51.7 years (37 to 81) with the mean 12 months follow-up between June, 2014, and January, 2016. FTSG was performed after sufficient granulation healing of DM foot amputee. We measured multiple risk factors preoperatively and postoperatively. The wound healing after FTSG was evaluated during the followup. The relationship between outcomes of FTSG and multiple risk factors were evaluated. Results: 20 feet showed complete healing of wound. One foot showed failed wound healing. Mean NPWT number of times before the FTSG were 11. Mean C-reactive protein (CRP) values and Hemoglobin A1C (HbA1C) were 1.24 and 9.21 just before FTSG, respectively. There were no significant correlations between wound healing and risk factors (CRP, HbA1C) (p=0.223, p=0.175). Conclusion: Full thickness skin graft combined with negative pressure wound therapy (NPWT) can be the treatment of choice for the diabetes mellitus foot amputee as an alternative STSG.

scholarly journals Effects of Negative Pressure Wound Therapy on Healing of Free Full-Thickness Skin Grafts in Dogs

2013 ◽  
Vol 42 (5) ◽  
pp. 511-522 ◽  
Author(s):  
Bryden J. Stanley ◽  
Kathryn A. Pitt ◽  
Christian D. Weder ◽  
Michele C. Fritz ◽  
Joe G. Hauptman ◽  
...  
Keyword(s):  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Skin Grafts ◽  
Full Thickness ◽  
Wound Therapy ◽  
Full Thickness Skin ◽  
Thickness Skin

138 Evaluation of Healing Outcomes Combining Negative Pressure Wound Therapy with Autologous Skin Cell Suspension and Meshed Autografts: Pre-Clinical and Clinical Evidence

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S92-S93
Author(s):  
Bonnie C Carney ◽  
Lauren T Moffatt ◽  
Taryn E Travis ◽  
Saira Nisar ◽  
John W Keyloun ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Cell Suspension ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Graft Loss ◽  
Full Thickness ◽  
Wound Therapy ◽  
Skin Cell ◽  
Cellular Suspension ◽  
Histological Architecture

Abstract Introduction Negative pressure wound therapy (NPWT) is an option for securing meshed split thickness skin grafts (mSTSGs) after burn excision to optimize skin graft adherence, working by minimizing disruption by shear forces and promoting the continual removal of wound bed drainage. Recently, the use of autologous skin cell suspension (ASCS) has been approved for use in treating full-thickness burn injuries in conjunction with mSTSGs. Limited data exists regarding the impact of NPWT on healing outcomes when the cellular suspension is utilized. It was hypothesized that NPWT in conjunction with ASCS+mSTSGs would aid in skin graft adherence without compromise to healing outcomes. Methods In this study, a Duroc pig model of burn, excision, mSTSG, ASCS + NPWT was used (n=2), where each animal had 2 sets of paired burns. Four wounds received mSTSG+ASCS+NPWT through post-operative day 3, and 4 wounds received mSTSG+ACSC+ traditional ASCS dressings. Percent re-epithelialization was measured using digital planimetry and Image J. Graft-adherence was evaluated using a scale with blinded reviewers (0=no graft loss, 4= >50% graft loss). Histological architecture, pigmentation, elasticity, and blood perfusion and blood vessel density were assessed at multiple time points through 2 weeks. After the evaluation of its effectiveness in animal models, the same surgical technique, including NPWT, was used in patients with full-thickness burns (n=9), and wound healing trajectories were described. Results In the Duroc pig study, all wounds healed within 14 days with minimal scar pathology and no significant differences in percent re-epithelialization between NPWT and non-NPWT wounds were observed (61.09 ± 9.01 and 61.15 ± 0.82% at Day 7). Additionally, no differences were detected for pigmentation, perfusion, or blood vessel density. Overall, the non-NPWT group had higher amounts of graft loss (1.0 ± 1.41 vs. 0 ± 0). NPWT-treated wounds had significantly improved elasticity (NPWT=109.5 ± 21.23 vs. non-NPWT=177.5 ± 35.4, p< 0.05). There were no differences in histological architecture between treatment groups. Patients had a median age of 53 (37–69), and median TBSA of 12.5 (8–18) resulting primarily from scald burns (67%). There were no reported morbidities, and all wounds were re-epithelialized within an expected time period. The use of NPWT promoted graft adherence, and was useful as a bolster dressing in wounds that crossed joints. Conclusions These data suggest the positive attributes of the cellular suspension delivered are retained following the application of NPWT. Re-epithelialization, revascularization, and repigmentation are not adversely impacted.

scholarly journals Impact of negative‐pressure wound therapy on bacterial behaviour and bioburden in a contaminated full‐thickness wound

2019 ◽  
Vol 16 (5) ◽  
pp. 1214-1221
Author(s):  
Zhirui Li ◽  
Qingwen Yu ◽  
Song Wang ◽  
Guoqi Wang ◽  
Tongtong Li ◽  
...  
Keyword(s):  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Full Thickness ◽  
Wound Therapy ◽  
Full Thickness Wound

An Application of a Negative-Pressure Wound Dressing for Partial- or Full-Thickness Burn Wounds

2020 ◽  
pp. 153473462093343
Author(s):  
Yulong Cheng ◽  
Zengding Zhou ◽  
Huan Hu ◽  
Wenbo Li ◽  
Yi Liu ◽  
...  
Keyword(s):  
Hospital Stay ◽  
Negative Pressure ◽  
Medical Records ◽  
Wound Dressing ◽  
Small Area ◽  
Negative Pressure Wound Therapy ◽  
Full Thickness ◽  
Wound Therapy ◽  
Vacuum Suction ◽  
Burn Wounds

Negative-pressure wound therapy is widely used in burn populations. Traditionally, negative-pressure devices use persistent vacuum suction, requiring a longer hospital stay. In this study, we applied a novel negative-pressure wound dressing for burn wounds, which eliminates the hospital stay. The medical records of 39 patients with partial-/full-thickness burns treated by negative-pressure wound dressing were retrospectively analyzed. The average burn area, burn degree, healing duration, cost, and incidents during treatment were determined and compared with previous data for conventional therapies. In conclusion, for patients diagnosed with partial-thickness or full-thickness burns and a burn area <34.6 ± 2.21 cm2, the negative-pressure wound dressing is a reliable option, especially for burnt children. Moreover, the negative-pressure wound dressing treatment was not only much cheaper than conventional therapies, but also eliminated hospital stay in patients with small-area deep burn wounds.

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