scholarly journals 1α,25-Dihydroxyvitamin D3Modulates the Hair-Inductive Capacity of Dermal Papilla Cells: Therapeutic Potential for Hair Regeneration

2012 ◽  
Vol 1 (8) ◽  
pp. 615-626 ◽  
Author(s):  
Noriyuki Aoi ◽  
Keita Inoue ◽  
Toshihiro Chikanishi ◽  
Ryoji Fujiki ◽  
Hanako Yamamoto ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Dermal Papilla ◽  
Dermal Papilla Cells ◽  
Hair Regeneration

scholarly journals Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e34152 ◽  
Author(s):  
Soung-Hoon Lee ◽  
Juyong Yoon ◽  
Seung Ho Shin ◽  
Muhamad Zahoor ◽  
Hyoung Jun Kim ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Alkaline Phosphatase ◽  
Phosphatase Activity ◽  
Alkaline Phosphatase Activity ◽  
Murine Model ◽  
Dermal Papilla ◽  
Dermal Papilla Cells ◽  
Hair Regeneration

Wnt1a maintains characteristics of dermal papilla cells that induce mouse hair regeneration in a 3D preculture system

2015 ◽  
Vol 11 (5) ◽  
pp. 1479-1489 ◽  
Author(s):  
Liang Dong ◽  
Haojie Hao ◽  
Jiejie Liu ◽  
Chuan Tong ◽  
Dongdong Ti ◽  
...  
Keyword(s):  
Dermal Papilla ◽  
Dermal Papilla Cells ◽  
Hair Regeneration

scholarly journals Rescuing key native traits in cultured dermal papilla cells for human hair regeneration

2020 ◽  
Author(s):  
Carla M. Abreu ◽  
Mariana T. Cerqueira ◽  
Rogério P. Pirraco ◽  
Luca Gasperini ◽  
Rui L. Reis ◽  
...  
Keyword(s):  
Human Hair ◽  
Dermal Papilla ◽  
Dermal Papilla Cells ◽  
Hair Regeneration

Cytokine loaded layer-by-layer ultrathin matrices to deliver single dermal papilla cells for spot-by-spot hair follicle regeneration

2016 ◽  
Vol 4 (3) ◽  
pp. 489-504 ◽  
Author(s):  
Bo-jie Lin ◽  
Jin Wang ◽  
Yong Miao ◽  
Yu-qing Liu ◽  
Wei Jiang ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Dermal Papilla ◽  
Layer By Layer ◽  
Dermal Papilla Cells ◽  
Hair Regeneration

Polymer nanocoated dermal papilla cells promoting hair regeneration.

scholarly journals Multipotent Neural Crest Stem Cell-Like Cells from Rat Vibrissa Dermal Papilla Induce Neuronal Differentiation of PC12 Cells

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Meiying Li ◽  
Jin Yu Liu ◽  
Shichao Wang ◽  
Hao Xu ◽  
Lifeng Cui ◽  
...  
Keyword(s):  
Conditioned Medium ◽  
Neuronal Differentiation ◽  
Pc12 Cells ◽  
Neurotrophic Factor ◽  
Therapeutic Potential ◽  
Dermal Papilla ◽  
Elisa Assay ◽  
Dermal Papilla Cells ◽  
Promising Source

Bone marrow mesenchymal stem cells (BMSCs) transplants have been approved for treating central nervous system (CNS) injuries and diseases; however, their clinical applications are limited. Here, we model the therapeutic potential of dermal papilla cells (DPCs)in vitro. DPCs were isolated from rat vibrissae and characterized by immunocytofluorescence, RT-PCR, and multidifferentiation assays. We examined whether these cells could secrete neurotrophic factors (NTFs) by using cocultures of rat pheochromocytoma cells (PC12) with conditioned medium and ELISA assay. DPCs expressed Sox10, P75, Nestin, Sox9, and differentiated into adipocytes, osteoblasts, smooth muscle cells, and neurons under specific inducing conditions. The DPC-conditioned medium (DPC-CM) induced neuronal differentiation of PC12 cells and promoted neurite outgrowth. Results of ELISA assay showed that compared to BMSCs, DPCs secreted more brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF). Moreover, we observed that, compared with the total DPC population, sphere-forming DPCs expressed higher levels of Nestin and P75 and secreted greater amounts of GDNF. The DPCs from craniofacial hair follicle papilla may be a new and promising source for treating CNS injuries and diseases.

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