scholarly journals High-Resolution Probe-Based Confocal Laser Endomicroscopy for Diagnosing Biliary Diseases

2021 ◽  
Author(s):  
Hiroki Koda ◽  
Kazuo Hara ◽  
Okuno Nozomi ◽  
Takamichi Kuwahara ◽  
Mizuno Nobumasa ◽  
...  
Keyword(s):  
High Resolution ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Biliary Diseases

Fluorescence In Vivo Endomicroscopy: High-Resolution, 3-Dimensional Confocal Laser Endomicroscopy (Part 1)

2021 ◽  
Vol 29 (2) ◽  
pp. 32-37
Author(s):  
Mohammedayaz Rangrez ◽  
Lindsay Bussau ◽  
Kishwar Ifrit ◽  
Peter Delaney
Keyword(s):  
High Resolution ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
3 Dimensional

scholarly journals Fluorescence In Vivo Endomicroscopy Part 2: Applications of High-Resolution, 3-Dimensional Confocal Laser Endomicroscopy

2021 ◽  
Vol 29 (3) ◽  
pp. 14-26
Author(s):  
Mohammedayaz Rangrez ◽  
Lindsay Bussau ◽  
Kishwar Ifrit ◽  
Mark C. Preul ◽  
Peter Delaney
Keyword(s):  
High Resolution ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
3 Dimensional

scholarly journals High resolution tracking of macrophage cells in deep organs and lymphatics using fluorescent polymer dots

RSC Advances ◽  
2019 ◽  
Vol 9 (19) ◽  
pp. 10966-10975 ◽  
Author(s):  
Shiyi Tang ◽  
Yixiao Guo ◽  
Yidian Yang ◽  
Yao Li ◽  
Yanhong Gao ◽  
...  
Keyword(s):  
High Resolution ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Macrophage Cells ◽  
Polymer Dots ◽  
Fluorescent Polymer

Fluorescent polymer dots for tracking macrophage cells in deep organs using probe-based confocal laser endomicroscopy (pCLE).

scholarly journals In Vivo Endomicroscopy of Lung Injury and Repair in ARDS: Potential Added Value to Current Imaging

2019 ◽  
Vol 8 (8) ◽  
pp. 1197 ◽  
Author(s):  
Olivier Lesur ◽  
Frédéric Chagnon ◽  
Réjean Lebel ◽  
Martin Lepage
Keyword(s):  
High Resolution ◽  
Real Time ◽  
Added Value ◽  
Optical Biopsy ◽  
Fluorescence Probes ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Complication Risk ◽  
Bedside Method

Background: Standard clinical imaging of the acute respiratory distress syndrome (ARDS) lung lacks resolution and offers limited possibilities in the exploration of the structure–function relationship, and therefore cannot provide an early and clear discrimination of patients with unexpected diagnosis and unrepair profile. The current gold standard is open lung biopsy (OLB). However, despite being able to reveal precise information about the tissue collected, OLB cannot provide real-time information on treatment response and is accompanied with a complication risk rate up to 25%, making longitudinal monitoring a dangerous endeavor. Intravital probe-based confocal laser endomicroscopy (pCLE) is a developing and innovative high-resolution imaging technology. pCLE offers the possibility to leverage multiple and specific imaging probes to enable multiplex screening of several proteases and pathogenic microorganisms, simultaneously and longitudinally, in the lung. This bedside method will ultimately enable physicians to rapidly, noninvasively, and accurately diagnose degrading lung and/or fibrosis without the need of OLBs. Objectives and Methods: To extend the information provided by standard imaging of the ARDS lung with a bedside, high-resolution, miniaturized pCLE through the detailed molecular imaging of a carefully selected region-of-interest (ROI). To validate and quantify real-time imaging to validate pCLE against OLB. Results: Developments in lung pCLE using fluorescent affinity- or activity-based probes at both preclinical and clinical (first-in-man) stages are ongoing—the results are promising, revealing correlations with OLBs in problematic ARDS. Conclusion: It can be envisaged that safe, high-resolution, noninvasive pCLE with activatable fluorescence probes will provide a “virtual optical biopsy” and will provide decisive information in selected ARDS patients at the bedside.

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