scholarly journals Analysis of the immune response in padel

2021 ◽  
Vol 8 (2) ◽  
pp. 134-140
Author(s):  
Cádiz Pía ◽  
Carlos Otín ◽  
Luis Páez ◽  
la de
Keyword(s):  
Immune Response ◽  
Inflammatory Response ◽  
Physiological Response ◽  
Acute Inflammatory Response ◽  
General State ◽  
Sports Performance ◽  
Before And After ◽  
Anti Inflammatory ◽  
High Level ◽  
Sports Activities

High intensity exercise and sports activities are closely related to a general state of inflammation that can lead to immunosuppression. This physiological response could decrease sports performance and even compromise the athlete's health. The objective of this study was to investigate the acute inflammatory response of a padel match. 15 elite players (28.2±7.9 years) participated voluntarily in the study. Different pro-inflammatory (IL-1ß, IL-2, IL-6, IL-7, IL-8, IL-12 and TNFa) and anti-inflammatory cytokines (IL-5, IL-10 and IL-13) were analyzed before and after a match. The results showed a decrease in IL-7 (p=0.007) and IL-8 (p<0.03) and increases in IL-10 (p<0.04). The results obtained suggest that the practice of high-level padel induces an anti-inflammatory response.

scholarly journals Acute inflammation and hematological response in Nile tilapia fed supplemented diet with natural extracts of propolis and Aloe barbadensis

2015 ◽  
Vol 75 (2) ◽  
pp. 491-496 ◽  
Author(s):  
G. Dotta ◽  
J. Ledic-Neto ◽  
ELT. Gonçalves ◽  
A. Brum ◽  
M. Maraschin ◽  
...  
Keyword(s):  
Immune Response ◽  
Inflammatory Response ◽  
Nile Tilapia ◽  
Acute Inflammation ◽  
Leukocyte Count ◽  
Acute Inflammatory Response ◽  
Swim Bladder ◽  
Aloe Barbadensis ◽  
Natural Extracts ◽  
Number Of Cells

This study evaluated the acute inflammatory response induced by carrageenin in the swim bladder of Nile tilapia supplemented with the mixture of natural extracts of propolis and Aloe barbadensis (1:1) at a concentration of 0.5%, 1% and 2% in diet during 15 days. Thirty-six fish were distributed into four treatments with three replicates: fish supplemented with 0.5% of admix of extracts of propolis and Aloe (1:1) injected with 500 µg carrageenin; fish supplemented with 1% of admix of extracts of propolis and Aloe (1:1) injected with 500 µg carrageenin; fish supplemented with 2% of admix of extracts of propolis and Aloe (1:1), injected with 500 µg carrageenin and unsupplemented fish injected with 500 µg carrageenin. Six hours after injection, samples of blood and exudate from the swim bladder of fish were collected. It was observed an increase in the leukocyte count in the swim bladder exudate of fish supplemented with extracts of propolis and Aloe injected with carrageenin. The most frequent cells were macrophages followed by granular leukocytes, thrombocytes and lymphocytes. Supplementation with propolis and Aloe to 0.5% caused a significant increase in the number of cells on the inflammatory focus mainly macrophages, cells responsible for the phagocytic activity in tissues, agent of innate fish immune response.

scholarly journals Depletion of Neutrophils Exacerbates the Early Inflammatory Immune Response in Lungs of Mice Infected withParacoccidioides brasiliensis

2016 ◽  
Vol 2016 ◽  
pp. 1-17 ◽  
Author(s):  
Paula Andrea Pino-Tamayo ◽  
Juan David Puerta-Arias ◽  
Damaris Lopera ◽  
Martha Eugenia Urán-Jiménez ◽  
Ángel González
Keyword(s):  
Monoclonal Antibody ◽  
Immune Response ◽  
Inflammatory Response ◽  
Paracoccidioides Brasiliensis ◽  
Yeast Cells ◽  
Histopathological Analysis ◽  
Acute Inflammatory Response ◽  
Fungal Load ◽  
Inflammatory Immune Response

Neutrophils predominate during the acute phase of theParacoccidioides brasiliensisinfection. Herein, we determined the role of the neutrophil during the early stages of experimental pulmonary paracoccidioidomycosis using a monoclonal antibody (mAb) specific for neutrophils. Male BALB/c mice were inoculated intranasally with1.5×106or2×106P. brasiliensisyeast cells. The mAb was administered 24 h before infection, followed by doses every 48 h until mice were sacrificed. Survival time was evaluated and mice were sacrificed at 48 h and 96 h after inoculation to assess cellularity, fungal load, cytokine/chemokine levels, and histopathological analysis. Neutrophils from mAb-treated mice were efficiently depleted (99.04%). Eighty percent of the mice treated with the mAb and infected with1.5×106yeast cells died during the first two weeks after infection. When mice were treated and infected with2×106yeast cells, 100% of them succumbed by the first week after infection. During the acute inflammatory response significant increases in numbers of eosinophils, fungal load and levels of proinflammatory cytokines/chemokines were observed in the mAb-treated mice. We also confirmed that neutrophils are an important source of IFN-γand IL-17. These results indicate that neutrophils are essential for protection as well as being important for regulating the early inflammatory immune response in experimental pulmonary paracoccidioidomycosis.

scholarly journals PathoBiochemistry-directed Guidelines for COVID-19

2021 ◽  
Author(s):  
Yuliya Buinitskaya ◽  
Clifford Wlodaver ◽  
Roman Gurinovich ◽  
Siarhei Kastsiuchenka
Keyword(s):  
Nitric Oxide ◽  
Immune Response ◽  
Severe Acute Respiratory Syndrome ◽  
Inflammatory Response ◽  
Therapeutic Interventions ◽  
Health Conditions ◽  
No Production ◽  
Acute Inflammatory Response ◽  
Therapeutic Guidelines ◽  
Oxidant Production

Patients with underlying health conditions are at risk for a poor outcome from Coronavirus disease 2019 (COVID-19). Using machine reasoning by the sci.AI system, we investigated the pathobiochemistry of this observation to generate therapeutic guidelines. Facts were extracted and linked from publications available in nlm.nih.gov and Europe PMC to form the dataset which was validated by medical experts. Previously we described how preexisting chronic inflammation renders the acute inflammatory response to Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) excessive translating the SARS-CoV-2 infection into the clinical COVID-19 syndrome. Herein we focus on therapeutic interventions that mitigate the immune response. In essence, from bench to bedside, as depicted in the Graphical Abstract, the clinical management of COVID-19 should aim at: A. Control of excessive oxidant production. B. Neutralization of excessive oxidants. C. Upregulation of nitric oxide (NO) production.

Lycopene rich extract from red guava ( Psidium guajava L.) displays anti-inflammatory and antioxidant profile by reducing suggestive hallmarks of acute inflammatory response in mice

2017 ◽  
Vol 99 ◽  
pp. 959-968 ◽  
Author(s):  
Andreanne G. Vasconcelos ◽  
Adriany das G.N. Amorim ◽  
Raimunda C. dos Santos ◽  
Jessica Maria T. Souza ◽  
Luan Kelves M. de Souza ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Psidium Guajava ◽  
Acute Inflammatory Response ◽  
Antioxidant Profile ◽  
Anti Inflammatory

scholarly journals Hyperbilirubinemia in Gunn Rats Is Associated with Decreased Inflammatory Response in LPS-Mediated Systemic Inflammation

2019 ◽  
Vol 20 (9) ◽  
pp. 2306 ◽  
Author(s):  
Petra Valaskova ◽  
Ales Dvorak ◽  
Martin Lenicek ◽  
Katerina Zizalova ◽  
Nikolina Kutinova-Canova ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Systemic Inflammation ◽  
Primary Hepatocytes ◽  
Inflammatory Status ◽  
Gunn Rats ◽  
Tnf Α ◽  
Before And After ◽  
Anti Inflammatory ◽  
Inflammatory Profile

Decreased inflammatory status has been reported in subjects with mild unconjugated hyperbilirubinemia. However, mechanisms of the anti-inflammatory actions of bilirubin (BR) are not fully understood. The aim of this study is to assess the role of BR in systemic inflammation using hyperbilirubinemic Gunn rats as well as their normobilirubinemic littermates and further in primary hepatocytes. The rats were treated with lipopolysaccharide (LPS, 6 mg/kg intraperitoneally) for 12 h, their blood and liver were collected for analyses of inflammatory and hepatic injury markers. Primary hepatocytes were treated with BR and TNF-α. LPS-treated Gunn rats had a significantly decreased inflammatory response, as evidenced by the anti-inflammatory profile of white blood cell subsets, and lower hepatic and systemic expressions of IL-6, TNF-α, IL-1β, and IL-10. Hepatic mRNA expression of LPS-binding protein was upregulated in Gunn rats before and after LPS treatment. In addition, liver injury markers were lower in Gunn rats as compared to in LPS-treated controls. The exposure of primary hepatocytes to TNF-α with BR led to a milder decrease in phosphorylation of the NF-κB p65 subunit compared to in cells without BR. In conclusion, hyperbilirubinemia in Gunn rats is associated with an attenuated systemic inflammatory response and decreased liver damage upon exposure to LPS.

scholarly journals Improvement in peripherical visual attentional performance in professional soccer players following a single neurofeedback training.

2021 ◽  
Author(s):  
Sacha Assadourian ◽  
Antony Branco Lopes ◽  
Arnaud Saj
Keyword(s):  
Training Session ◽  
Soccer Players ◽  
Sports Performance ◽  
Attentional Deficits ◽  
Professional Soccer ◽  
Before And After ◽  
Eeg Neurofeedback ◽  
New Processing ◽  
Attentional Tasks ◽  
High Level

The effectiveness of EEG-neurofeedback (EEG-NFB) in modulating cognition has been the subject of much research for several years, particularly in relation to attentional functions in healthy subjects and those with attentional deficits. However, its effectiveness on sports performance remains poorly studied and its use is not widely practised among athletes, notably because of its accessibility and questionable effectiveness. The aim of this study is to show that this technology can be accessible, and that Alpha EEG-NFB is immediately effective. Fifteen professional soccer players took part in this study. Using a novel EEG headset that can be installed in less than one minute, and new processing software, the players performed two peripherical attentional tasks before and after, immediately and one month, a single Alpha EEG-NFB training session. The results showed a significant effect on both tasks immediately after EEG-NFB training, with a benefit of more than 30% and this performance continued after one month (20%). This study, the first to use this headset and software, shows that the improvement in sports performance can be related to cognitive performance, especially peripherical visual attentional functions. Furthermore, it demonstrates that the use of the EEG-NFB is accessible and effective for high-level athletes.

scholarly journals Sperm enter glands of preovulatory bovine endometrial explants and initiate inflammation

Reproduction ◽  
2020 ◽  
Vol 159 (2) ◽  
pp. 181-192 ◽  
Author(s):  
Ihshan Akthar ◽  
Susan S Suarez ◽  
Vernadyn A Morillo ◽  
Motoki Sasaki ◽  
Mohamed A Ezz ◽  
...  
Keyword(s):  
Immune Response ◽  
Epithelial Cells ◽  
Inflammatory Response ◽  
Fluorescent Labeling ◽  
Polymorphonuclear Neutrophils ◽  
Surface Epithelium ◽  
Acute Inflammatory Response ◽  
Sperm Binding ◽  
A Site ◽  
Uterine Glands

We previously reported that sperm binding to cultured monolayers of bovine uterine epithelial cells induces an acute inflammatory response involving the Toll-like receptor (TLR2) signaling pathway. This response serves to clear the uterus of sperm and thereby prepares the endometrium for implantation. The endometrium is lined by surface epithelial cells; however, epithelial cells also line uterine glands. To investigate the source of the immune response, we used an explant model. Explants of bovine endometrium were incubated with bull sperm illuminated by JC1 fluorescent labeling in their mitochondria. The sperm glided over the surface epithelium until they encountered and entered uterine glands, where they remained. Scanning electron microscopy of explants revealed polymorphonuclear neutrophils (PMNs) in uterine glands along with sperm. In the absence of sperm, PMNs were not seen in glands. The incubation of sperm with explants resulted in an acute inflammatory response, seen as the upregulation of mRNA expression of IL8, TNFA, IL1B, PGES and TLR2 in whole explants, as well as increased TNFA protein expression in uterine glands. TLR1/2 antagonist reduced sperm numbers in the glands and inhibited the increase of TNFA. Our observations suggest that uterine glands serve as a site where sperm interact with the uterine epithelium to trigger the innate immune response to clear excess sperm from the uterus.

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