scholarly journals Green tea and bilberry protective effect against gentamicin-induced nephrotoxicity in rats

2020 ◽  
Vol 37 (3) ◽  
pp. 261-266
Author(s):  
Milica Veljković ◽  
Dragana Pavlović ◽  
Ivan Ilić ◽  
Dušan Sokolović
Keyword(s):  
Protective Effect ◽  
Green Tea ◽  
Biochemical Analysis ◽  
Histological Analysis ◽  
Basal Membrane ◽  
Bactericidal Effect ◽  
Proximal Tubules ◽  
Glomerular Basal Membrane ◽  
Complete Disruption ◽  
Distal Tubules

The aim of our study was to investigate if green tea and bilberry have protective effect on gentamicin-induced kidney damage, when applied together, and to make a connection between their effects. GM group of rats received only gentamicin, GT group received green tea only, B group received only bilberry, whereas control (C) group received saline only. GT+GM group received green tea together with gentamicin, and B+GM group received bilberry together with gentamicin. Biochemical analysis showed significantly increased urea and creatinine levels in GM group when compared to groups that also received bilberry or green tea. Histological analysis showed complete disruption of glomerular basal membrane as well as basal membranes of both proximal and distal tubules in GM group. These destructive effects were significantly milder and limited only to proximal tubules when bilberry or green tea was applied simultaneously with gentamicin. Both green tea and bilberry protective effect on gentamicin-induced nephrotoxicity is manifested because of their strong antioxidant activity. Since they are strong antioxidants, widely distributed in nature, they can offer available and inexpensive adjuvant therapy in Gram-negative infections, which can relieve gentamicin nephrotoxicity, but will not affect its bactericidal effect.

Modeling the Effects of Temperature, Sodium Chloride, and Green Tea and Their Interactions on the Thermal Inactivation of Listeria monocytogenes in Turkey†

2014 ◽  
Vol 77 (10) ◽  
pp. 1696-1702 ◽  
Author(s):  
VIJAY K. JUNEJA ◽  
JIMENA GARCIA-DÁVILA ◽  
JULIO CESAR LOPEZ-ROMERO ◽  
ETNA AIDA PENA-RAMOS ◽  
JUAN PEDRO CAMOU ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Sodium Chloride ◽  
Protective Effect ◽  
Heat Resistance ◽  
Green Tea ◽  
Thermal Inactivation ◽  
Heating Temperature ◽  
Lethal Effect ◽  
Interactive Effects ◽  
D Values

The interactive effects of heating temperature (55 to 65°C), sodium chloride (NaCl; 0 to 2%), and green tea 60% polyphenol extract (GTPE; 0 to 3%) on the heat resistance of a five-strain mixture of Listeria monocytogenes in ground turkey were determined. Thermal death times were quantified in bags that were submerged in a circulating water bath set at 55, 57, 60, 63, and 65°C. The recovery medium was tryptic soy agar supplemented with 0.6% yeast extract and 1% sodium pyruvate. D-values were analyzed by second-order response surface regression for temperature, NaCl, and GTPE. The data indicated that all three factors interacted to affect the inactivation of the pathogen. The D-values for turkey with no NaCl or GTPE at 55, 57, 60, 63, and 65°C were 36.3, 20.8, 13.2, 4.1, and 2.9 min, respectively. Although NaCl exhibited a concentration-dependent protective effect against heat lethality on L. monocytogenes in turkey, addition of GTPE rendered the pathogen more sensitive to the lethal effect of heat. GTPE levels up to 1.5% interacted with NaCl and reduced the protective effect of NaCl on heat resistance of the pathogen. Food processors can use the predictive model to design an appropriate heat treatment that would inactivate L. monocytogenes in cooked turkey products without adversely affecting the quality of the product.

THE EFFECTS OF MANDUCA SEXTA DIURETIC HORMONE ON FLUID TRANSPORT BY THE MALPIGHIAN TUBULES AND CRYPTONEPHRIC COMPLEX OF MANDUCA SEXTA

1993 ◽  
Vol 178 (1) ◽  
pp. 231-243 ◽  
Author(s):  
N. Audsley ◽  
G. M. Coast ◽  
D. A. Schooley
Keyword(s):  
Cyclic Amp ◽  
Manduca Sexta ◽  
Fluid Transport ◽  
Basal Membrane ◽  
Fluid Secretion ◽  
Hormonal Control ◽  
Malpighian Tubules ◽  
Proximal Tubules ◽  
Fluid Absorption ◽  
Diuretic Hormone

1. Manduca sexta diuretic hormone (Mas-DH) stimulates fluid secretion by adult Malpighian tubules of M. sexta, demonstrating its site of diuretic action in M. sexta for the first time. It was not possible to develop a suitable bioassay to measure fluid secretion in larval proximal tubules. 2. Mas-DH has an antidiuretic action on the cryptonephric complex of larval M. sexta because it increases fluid absorption from the rectum. It appears that in this complex Mas-DH is acting on a Na+/K+/2Cl- co-transporter, presumably on the basal membrane of the cryptonephric Malpighian tubules, because Mas-DH-stimulated fluid absorption by the cryptonephric complex is inhibited by bumetanide or the removal of Cl-, Na+ or K+ from the haemolymph side of the tissue. This is the first demonstration of hormonal control of fluid absorption by the cryptonephric complex. 3. Concomitant with the stimulation of fluid transport, Mas-DH increases the amount of cyclic AMP secreted by adult Malpighian tubules and the cryptonephric complex. In addition, Mas-DH promotes cyclic AMP production by the larval proximal tubules.

Ochratoxin A and Citrinin Induced Nephrosis in Beagle Dogs II. Pathology

1977 ◽  
Vol 14 (3) ◽  
pp. 261-272 ◽  
Author(s):  
D. N. Kitchen ◽  
W. W. Carlton ◽  
J. Tuite
Keyword(s):  
Ochratoxin A ◽  
Proximal Tubules ◽  
Lymphoid Tissues ◽  
Tubular Epithelial Cells ◽  
Beagle Dogs ◽  
Peripheral Lymph ◽  
Collecting Ducts ◽  
Gross Lesions ◽  
Colon And Rectum ◽  
Distal Tubules

Beagle dogs were given ochratoxin A (0.1 and 0.2 mg/kg) and citrinin (5 and 10 mg/kg) alone and in two dose combinations for 14 days. The gross lesions included focal peritonitis and intestinal intussusceptions in dogs given citrinin. Changes in the kidneys of dogs given ochratoxin A were degeneration and necrosis with desquamation of tubular epithelial cells, primarily in the straight segment of the proximal tubules. Dogs given 10 mg/kg citrinin had similar changes in the distal tubules and collecting ducts. Dogs given combined doses of citrinin and ochratoxin A had degeneration and necrosis in proximal and distal tubules, and in thin segments and the collecting ducts; there were desquamated cells and granular casts in the lumina. Dogs given ochratoxin A had necrosis of lymphoid tissues in the spleen, tonsil, thymus, peripheral lymph nodes and lymph nodules of the ileum, colon and rectum. There was ulceration of the mucosa of the intestine in dogs given large combined doses of ochratoxin A and citrinin.

Protective effect of green tea extract against proline-induced oxidative damage in the rat kidney

2016 ◽  
Vol 83 ◽  
pp. 1422-1427 ◽  
Author(s):  
Débora Delwing-Dal Magro ◽  
Roberto Roecker ◽  
Gustavo M. Junges ◽  
André F. Rodrigues ◽  
Daniela Delwing-de Lima ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Protective Effect ◽  
Green Tea ◽  
Rat Kidney ◽  
Green Tea Extract ◽  
Tea Extract

scholarly journals Safety of Aqueous Extract of Calea ternifolia Used in Mexican Traditional Medicine

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Ma G. E. González-Yáñez ◽  
Catalina Rivas-Morales ◽  
María A. Oranday-Cárdenas ◽  
María J. Verde-Star ◽  
María A. Núñez-González ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Aqueous Extract ◽  
Histological Analysis ◽  
Liver Enzymes ◽  
Renal Tissue ◽  
Proximal Tubules ◽  
Hepatic Toxicity ◽  
Treatment Of Diabetes

There is a trend to use medicinal plants for primary medical care or as dietary supplements; however, the safety of many of these plants has not been studied. The objective of this work was to determine the toxic effect of the aqueous extract of Calea ternifolia (C. zacatechichi), known popularly as “dream herb” in vivo and in vitro in order to validate its safety. In vivo, the extract had moderate toxicity on A. salina. In vitro, the extract induced eryptosis of 73% at a concentration of 100 μg·mL−1 and it inhibited CYP3A by 99% at a concentration of 375 μg/mL. After administering 8.5 mg/kg of C. ternifolia to rats, we found a reduction in platelets and leukocytes and an increase in urea and the liver enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). Histological analysis showed spongiform changes in the proximal tubules of renal tissue and a lymphoid infiltrate in liver tissue. This plant is used in the treatment of diabetes, and it is commercialized as a dietary supplement in several countries. Our results show renal and hepatic toxicity; therefore, more profound research on the toxicity of this plant is needed.

Protective effect of green tea against prostate cancer: A case-control study in southeast China

2003 ◽  
Vol 108 (1) ◽  
pp. 130-135 ◽  
Author(s):  
Le Jian ◽  
Li Ping Xie ◽  
Andy H. Lee ◽  
Colin W. Binns
Keyword(s):  
Prostate Cancer ◽  
Protective Effect ◽  
Green Tea ◽  
Case Control Study ◽  
Case Control ◽  
Southeast China ◽  
Control Study
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