scholarly journals ACE I/D Gene Polymorphism in Children with Family History of Premature Coronary Disease

2014 ◽  
Author(s):  
Dilek Yý lmaz Çiftdoð na
Keyword(s):  
Family History ◽  
Gene Polymorphism ◽  
Coronary Disease ◽  
History Of

P5329Montreal score and coronary artery calcification in the prediction of cardiovascular event in patients with familial hypercholesterolemia

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
M Miname ◽  
M S B Bittencourt ◽  
C E J Jannes ◽  
A C P Pereira ◽  
J E K Krieger ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Family History ◽  
Familial Hypercholesterolemia ◽  
Coronary Disease ◽  
Roc Curve ◽  
Cox Regression ◽  
Univariate Analysis ◽  
Cvd Risk ◽  
Cox Regression Analysis ◽  
History Of

Abstract Introduction Familial hypercholesterolemia (FH) is characterized by elevated levels of LDL-C and early cardiovascular disease (CVD). However, the risk of CVD in HF is variable. The Montreal score was designed to stratify cardiovascular risk in the FH population. Coronary calcium score (CAC) is a tool that can be used to optimize CVD risk assessment in FH. Purpose The objective of this study is to evaluate whether CAC is superior to the Montreal score in cardiovascular risk discrimination in FH. Methods We Included 206 patients with molecular diagnosis of FH (36.4% men, mean age 45±14 years, mean baseline LDL-C: 269±70 mg/dL). All patients underwent CAC and were treated with maximum tolerated statin therapy. We evaluated cardiovascular risk factors and calculated Montreal score as prior publication. Cox regression analysis was performed to test the association of CAC with the incidence of cardiovascular events. CAC was transformed into LogCAC + 1 to optimize the distribution of the CAC as previously described. Area under the ROC curve was calculated for Montreal score and CAC. Results Patients were followed by a median of 3.7 years (interquartile range: 2.7 to 6.8 years). Mean Montreal score was 22±8, median of 22. CAC was positive in 105 individuals (51%) and 15 CVD events (7.2%) had occurred. Montreal score above the median was associated with CAC (OR: 8.36, 95% CI: 4.47–15.62, p<0.001), and there was a gradient of increase in the Montreal score with CAC increase (mean Montreal score for CAC = 0, CAC 1–100, CAC>100: 17±7, 23±7, 30±4, p<0.001). Univariate analysis showed that the following variables were associated with CVD occurrence: male gender, family history of early coronary disease, corneal arcus, HDL-c (protective), logCAC + 1 and Montreal score. Multivariate analysis was performed: model 1 with Montreal score and logCAC + 1, only logCAC + 1 was associated with the occurrence of CVD (RR: 3.886; 95% CI: 2.112–7.148, p<0.001). Model 2 with family history of early coronary disease, corneal arcus, logCAC + 1 and Montreal score, only the latter was not associated with the occurrence of CVD. CAC presents greater area under the ROC curve for CVD event discrimination compared to the Montreal score: 0.839 versus 0.685, p=0.0074. Conclusion The Montreal score is associated with CAC in FH, however CAC is superior than this clinical score in predicting the occurrence of CVD in FH.

scholarly journals Coronary calcium scoring for long-term mortality prediction in patients with and without a family history of coronary disease

Heart ◽  
2015 ◽  
Vol 102 (3) ◽  
pp. 204-208 ◽  
Author(s):  
Joseph T Knapper ◽  
Faisal Khosa ◽  
Michael J Blaha ◽  
Taylor A Lebeis ◽  
Jenna Kay ◽  
...  
Keyword(s):  
Family History ◽  
Coronary Disease ◽  
Mortality Prediction ◽  
Coronary Calcium ◽  
Calcium Scoring ◽  
Coronary Calcium Scoring ◽  
History Of ◽  
Long Term Mortality

Erythrocyte Passive Potassium Flux is Increased in Patients with Ischemic Coronary Disease (ICD) and in Subjects with Family History of ICD

Angiology ◽  
1998 ◽  
Vol 49 (7) ◽  
pp. 549-555
Author(s):  
Antonino Saitta ◽  
Michele N. Saitta ◽  
Michele Bonaiuto ◽  
Maria Castaldo ◽  
Adriana Sardo ◽  
...  
Keyword(s):  
Family History ◽  
Coronary Disease ◽  
Potassium Flux ◽  
History Of ◽  
Ischemic Coronary Disease
Sign in / Sign up

Export Citation Format

Share Document