scholarly journals Extraction and Evaluation of Lepidium Sativum and Flax Seeds Mucilage as a Pharmaceutical Granulation Binder

2021 ◽  
Author(s):  
Nagla Algali Layas
Keyword(s):  
Physical Properties ◽  
Angle Of Repose ◽  
Lepidium Sativum ◽  
Wet Granulation ◽  
Binding Agent ◽  
Flax Seeds ◽  
Good Flow

The powders holdtogether by a binder to form granule. Some excipients of natural origins arecurrently available as an alternative over the synthetic ones in pharmaceuticalformulation. The aim of this study was to isolate the mucilage from differentplant seeds and compare them to evaluate the binding effects. In present studyan effort was made to investigate the efficacy of mucilage obtained from Lepidiumsativum and flax seeds as granules excipient. The mucilage   was extracted from selected seeds byconventional method by precipitation of soaked and blended seeds in acetone.The dried mucilages were subjected to several phytochemical and physicochemicalproperties. Granules were formulated by wet granulation method by usingextracted mucilage as a binding agent and comparison was made against thegranules prepared with standard binder as PVP. The granules evaluated byvarious physical properties such as (bulk and tapped densities, Hausner’sratio, Carr’s index, angle of repose and friability). The results showed thatthe granules prepared from extracted mucilage as a binder had good flow andmechanical properties, all evaluated parameters were within the permissiblelimits. Thus, mucilage could be used as an alternative binding agent in pharmaceuticalgranules.

Exploration of Neem Gum, Acrylamide Grafted Neem Gum and Carboxymethylated Neem Gum as Retardant in Tablet Formulation

2020 ◽  
Vol 16 (9) ◽  
pp. 1404-1410
Author(s):  
Rishabha Malviya
Keyword(s):  
Diclofenac Sodium ◽  
Tablet Formulation ◽  
Angle Of Repose ◽  
Wet Granulation ◽  
Binding Agent ◽  
Grafted Polymer ◽  
Model Drug ◽  
Tablet Dosage ◽  
Tapped Density ◽  
Derivatives Of

Background: In the previous study, investigators have synthesized acrylamide grafted and carboxymethylated derivatives of neem gum and evaluated their potential in the formulation of nanoparticles. In continuation of previous work, authors have evaluated neem gum polysaccharide (NGP), acrylamide grafted neem gum polysaccharide (NGP-g-Am) and carboxymethylated neem gum polysaccharide (CMNGP) as binding agent in the tablet dosage form. Methods: Diclofenac sodium was used as a model drug while microcrystalline cellulose and talc were used as excipient in the preparation of granules employing wet granulation technique. NGP, NGP-g-Am and CMNGP were utilized as binding agent in the preparation of granules. Prepared granules were characterized for various pre-compression and post-compression parameters. Results and Discussion: Binding agents were used in the concentration of 4-24%w/w. NGP incorporated granules showed more bulk density and lower values of tapped density, Carr’s index, bulkiness, Hausner’s ratio and angle of repose as compared to NGP-g-Am consisting granules. NGP-g-Am consisting tablets showed more hardness and zero friability as compared to NGP based tablets. Drug content was found lower for the tablets having grafted polymer in place of NGP. CMNGP were also utilized to prepare granules but granules were not be able to compress keeping all the compacting parameters same as used in the case of NGP and NGP-g-Am consisting granules. NGP and NGP-g-Am were able to sustain drug release up to 6 and 8 h, respectively. Conclusion: It can be concluded that NGP-g-Am induces better properties when used as a binder in the tablet formulation than native polymer, while CMNGP cannot be utilized as a binding agent in the preparation of a tablet.

scholarly journals Physical Properties of Seeds of the Selected Oil Plants

2016 ◽  
Vol 20 (1) ◽  
pp. 69-77
Author(s):  
Marta Krajewska ◽  
Beata Ślaska-Grzywna ◽  
Dariusz Andrejko
Keyword(s):  
Physical Properties ◽  
Food Processing ◽  
Cannabis Sativa ◽  
Nigella Sativa ◽  
Angle Of Repose ◽  
Lepidium Sativum ◽  
Research Material ◽  
Winter Rapeseed ◽  
Single Seeds ◽  
Compressive Resistance

AbstractThe paper examines the selected physical properties of seeds of 8 plants used in agri-food processing industry. These are: winter rapeseed (Brassica napus L.) Adriana cultivar, sesame (Sesamumindicum L.), common flax (Linum usitatissimum L.) Luna cultivar, husked sunflower (Helianthus L.) (country of origin – Bulgaria), hemp (Cannabis sativa L.) Benikocultivar, blue poppy (Papaver somniferum L.) Major cultivar, garden cress (Lepidium sativum L.), black caraway (Nigella Sativa L.). In the research material we determined the following: mass of thousand seeds (MTS), piling angle and angle of repose, tap and bulk density and compressive resistance of single seeds. Some seeds from the selected plant species differed with shape and size. Thus, the results determining the physical properties were varied.

scholarly journals Evaluasi Granul Ekstrak Daun Nangka (Artocarpus heterophyllus L.) dengan Menggunakan Metode Granulasi Basah

2021 ◽  
Vol 1 ◽  
pp. 1182-1193
Author(s):  
Intan Amalina Istiqomah ◽  
Dwi Bagus Pambudi ◽  
St. Rahmatullah ◽  
S Slamet
Keyword(s):  
Physical Properties ◽  
Water Content ◽  
Flow Rate ◽  
Leaf Extract ◽  
Extraction Process ◽  
Angle Of Repose ◽  
Wet Granulation ◽  
Artocarpus Heterophyllus ◽  
Pharmacological Studies ◽  
Rate Test

AbstractJackfruit leaf (Artocarpus heterophyllus L.) is a potential plant that has passed pharmacological studies showing its anti-inflammatory, antibacterial, antiviral, anticancer, antihypertensive, and diuretic activities. The purpose of this study was to determine whether the granules of jackfruit leaf extract (Artocarpus heterophyllus L.) met the physical requirements of good granules. The first step in this research is to carry out the simplicia extraction process of jackfruit leaves using the maceration method using 96% ethanol as solvent. And in the manufacture of granules using the wet granulation method. In the study, the results of the evaluation of the granules of the angle of repose of formula I and formula IV were 24,220, formula II and formula III were 26,380. The average Granule Flow Rate Test for formula I is 3.4 seconds, formula II averages 2.91 seconds, formula III averages 2.59, and formula IV averages 2.75 seconds and falls into the cohesive range. The water content test in formulas I, II, III, and IV was 1%. And in the compressibility test of formula I the results are 11%, formula II is 7.85%, formula III is 8.99%, and formula IV is 3.92%. From these data, it can be concluded that the granules in formulas I, II, III, and IV have good physical properties because in the physical properties test all formulas meet the requirements.Keywords: Jackfruit leaves; granule evaluation; granules; wet granulation. AbstrakDaun Nangka (Artocarpus heterophyllus L.) adalah tanaman potensial yang telah melewati studi farmakologi yang menunjukkan adanya aktivitas antiinflamasi, antibakteri, antivirus, antikanker, antihipertensi, dan diuretik. Tujuan dari penelitian ini adalah mengetahui apakah granul ekstrak daun nangka (Artocarpus heterophyllus L.) memenuhi persyaratan fisik granul yang baik. Langkah pertama pada penelitian ini adalah dengan melakukan proses ekstraksi simplisia daun nangka menggunakan metode maserasi dengan menggunakan pelarut etanol 96%. Dan pada pembuatan granul dengan menggunakan metode granulasi basah. Pada penelitian didapatkan hasil evaluasi granul sudut diam formula I dan formula IV hasilnya 24,220, formula II dan formula III hasilnya 26,380. Uji Laju Alir Granul formula I rata-ratanya 3,4 detik, formula II rata-ratanya 2,91 detik, formula III rata-ratanya 2,59, dan formula IV rata-ratanya 2,75 detik dan masuk kedalam rentang kohesif. Uji Kadar air pada formula I, II, III, dan IV hasilnya adalah 1%. Dan pada uji kompresibilitas formula I hasilnya 11%, formula II 7,85%, formula III 8,99%, dan formula IV 3,92%. Dari data tersebut dapat disimpulkan bahwa granul pada formula I, II, III, dan IV memiliki sifat fisik yang baik karena pada uji sifat fisik granul semua formula memenuhi syarat. Kata kunci : Daun nangka; evaluasi granul; granul; granulasi basah.

FORMULASI GRANUL EFFERVESCENT EKSTRAK ETANOL 90% BUAH LABU AIR (Lagenaria siceraria) SEBAGAI ANTIOKSIDAN DENGAN VARIASI GAS GENERATING AGENT

2020 ◽  
Vol 5 (2) ◽  
pp. 220-229
Author(s):  
Dyera Forestryana ◽  
◽  
Yunitha Hestiarini ◽  
Aristha Novyra Putri
Keyword(s):  
Citric Acid ◽  
Moisture Content ◽  
Sodium Bicarbonate ◽  
Physical Properties ◽  
Tartaric Acid ◽  
Angle Of Repose ◽  
Wet Granulation ◽  
Lagenaria Siceraria ◽  
Flow Properties ◽  
Compressibility Index

Water pumpkin (Lagenaria siceraria) is a vegetable that contains secondary metabolites that are beneficial to health. Its use as a vegetable is less attractive to the people so that to increase its utilization, dosage forms are made that can attract public interest, one of which is effervescent granules. Effervescent granules are the most popular dosage form because they can serve in fresh drinks. This study aims to determine the effect of variations in the concentration of acids (citric acid-tartaric acid) and base (sodium bicarbonate) on the physical properties of the formula. The water pumpkin effervescent granules made with various ratios of citric acid, tartaric acid, and sodium bicarbonate consisting of FI (2: 1: 2.5); F II (1: 2: 2,5); F III (2: 1: 3,52); F IV (1: 2: 3,44). The granule made by the wet granulation method. The physical properties of the formula included organoleptic, moisture content, flow properties, compressibility index, pH, solubility time, and acceptability test. Based on the results of the evaluation of physical properties, the granule formula of the water pumpkin effervescent meets the standard requirements with a moisture content of 1.26% -2.26%, flow properties from 6.33 to 7.0 seconds, angle of repose 31.14˚-33.69 ˚, compressibility index 13.61% -17.08%, pH 6.1-7.1 and dissolving time 191-223.33 seconds. Variations of citric acid-tartaric acid and sodium bicarbonate affect the physical properties and taste of the effervescent granules. Based on the acceptability test showed that the panelists liked the water pumpkin effervescent granules in FII.

scholarly journals Formulasi Tablet Paracetamol dengan Bahan Pengikat Pati Umbi Gembili (Dioscorea esculenta L)

2019 ◽  
Vol 6 (2) ◽  
pp. 55
Author(s):  
Elya Zulfa ◽  
Malinda Prihantini
Keyword(s):  
Physical Properties ◽  
Descriptive Analysis ◽  
Physical Characteristics ◽  
Wet Granulation ◽  
Test Results ◽  
Binding Agent ◽  
Disintegration Time

ABSTRAK Pati umbi gembili (PUG) memiliki kandungan utama amilopektin sebesar 75,7%. Amilopektin bersifat lekat dan dapat membentuk gel bila disuspensikan dengan air, sehingga dapat dimanfaatkan sebagai bahan pengikat. Tujuan penelitian ini adalah mengetahui sifat fisik tablet paracetamol dengan penambahan PUG sebagai bahan pengikat.  Proses pembuatan pati dari umbi gembili dilakukan dengan cara basah. Tablet Parasetamol dibuat dengan metode granulasi basah dengan variasi kadar mucilago PUG FI 5%, FII 10%, FIII 15%. Tablet yang dibuat, diuji sifat fisik (keseragaman bobot, kekerasan, kerapuhan dan waktu hancur) dan dianalisis secara deskriptif. Hasil uji sifat fisik tablet menunjukkan bahwa seluruh formula yang dibuat memenuhi syarat yang ditetapkan dalam kompendial. Kata Kunci :  Parasetamol, pati umbi gembili, bahan pengikat, granulasi basah  ABSTRACT Gembili tuber (PUG) starch has a major component of amylopectin of 75.7%. Amylopectin is sticky and can form a gel when suspended with water, so that it can be used as a tablet binding agent in the form of PUG mucilago. The purpose of this study was to determine the physical characteristics in paracetamol tablets of adding PUG mucilago (Dioscorea esculenta) as a binder. The process of making starch from gembili tuber is done by wet. Paracetamol tablets are made by wet granulation method with variations in levels of FI PUG mucilago 5%, FII 10%, FIII15%. Tablets were made, tested for physical properties (weight uniformity, hardness, friability and disintegration time) with descriptive analysis. The test results of the physical properties of tablets indicate that all formulas made meet the requirements set out in the literature Keywords: Paracetamol, gembili tuber starch, binder, wet granulation

Formulation and Evaluation of Sustained Release Bilayer Matrix Tablet of Glimepiride and Metformin Hydrochloride

2021 ◽  
pp. 273-279
Author(s):  
Mayuri B. Patil ◽  
Avish D. Maru ◽  
Jayshree S. Bhadane
Keyword(s):  
Sustained Release ◽  
Type Ii Diabetes ◽  
In Vitro Release ◽  
Angle Of Repose ◽  
Metformin Hydrochloride ◽  
Wet Granulation ◽  
Matrix Tablet ◽  
Type Ii ◽  
Weight Variation

The aim of the present study was to design and evaluate bilayer tablets of metformin hydrochloride as sustained release form for the treatment of Type-II diabetes mellitus. The basic aim of any Bi-layer tablet formulation is to separate physically or chemically incompatible ingredients and to produce repeat action or prolonged action of tablet. They are many drugs for treating type-II diabetes. Sulphonyl urea and biguanides are used commonly by a wide section of patients. Melt granulation process was used for the formulation of sustained comprising metformin layer and wet granulation of immediate comprising layer of glimepiride. The precompression studies like bulk density, tapped density, angle of repose, compressible index and post formulation studies includes weight variation, hardness, thickness, friability and dissolution study. The in-vitro release profile of Glimepiride was dissolved within 45 min, and Metformin Hydrochloride was able to release more than 12 hrs. They all the formulation was optimized formula due to its higher rate of dissolution and collate all other parameters with the official specifications.

scholarly journals FORMULATION AND EVALUATION OF FLURBIPROFEN FAST DISINTEGRATING TABLETS USING NATURAL SUPERDISINTEGRANTS

2016 ◽  
Vol 9 (6) ◽  
pp. 247 ◽  
Author(s):  
Mohammed Sarfaraz ◽  
Surendra Kumar Sharma
Keyword(s):  
Drug Release ◽  
Angle Of Repose ◽  
Lepidium Sativum ◽  
Disintegration Time ◽  
Natural Sources ◽  
Weight Variation ◽  
Wetting Time ◽  
Tapped Density ◽  
Fast Disintegrating Tablets

ABSTRACTObjective: The main objective of this research was to formulate Fast disintegrating tablets of Flurbiprofen incorporating superdisintegrants, isolated from natural sources like Plantago ovata (PO) seeds, Lepidium sativum (LS) seeds and agar-agar.Methods: Superdisintegrants were isolated from their natural sources using reported methods. Swelling index and hydration capacity was determined for the natural superdisintegrants to know their disintegration capacity. The tablet formulations were designed using isolated natural superdisintegrants. The powder blends were evaluated for pre-compressional parameters like angle of repose, bulk density, tapped density, carr’s index, and hausner’s ratio. Fast disintegrating tablets were prepared by direct compression method. The compressed tablets were characterized for post compression parameters.Results: All formulations had hardness, friability, weight variation and drug content within the pharmacopoeial limits. The wetting time was 84 to 254 sec, in vitro disintegration time was between 59.2 to 221 sec, and in-vitro drug release was as low as 11.80% (LS1) to a maximum of 98.99% (PO4) after 4 min of study. Among all, optimized formulation was PO4, as it showed good wetting time (84 sec), fastest disintegration time (59.2 sec), dispersion time (135 sec) and drug release of 98.99.% within 4 min.Conclusion: Flurbiprofen FDT’s were successfully developed using isolated natural disintegrants. The natural disintegrants isolated showed promising results and can prove as effective alternative for synthetic disintegrants.

scholarly journals IMPROVEMENT OF MICROMERITIC, COMPRESSIBILITY AND SOLUBILITY CHARACTERISTICS OF LINEZOLID BY CRYSTALLO-CO-AGGLOMERATION TECHNIQUE

2017 ◽  
Vol 9 (4) ◽  
pp. 47 ◽  
Author(s):  
Atul M. Kadam ◽  
Shitalkumar S. Patil
Keyword(s):  
Drug Release ◽  
Methyl Cellulose ◽  
Mechanical Deformation ◽  
Angle Of Repose ◽  
Scanning Electronic Microscopy ◽  
Electronic Microscopy ◽  
X Ray ◽  
Fourier Transformation Infrared Spectroscopy ◽  
Time Required ◽  
Good Flow

Objective: The purpose of current study was to improve physicochemical properties such as micrometric, compressibility and solubility of linezolid (LNZ) by preparing crystallo-co-agglomerates (CCA) in the presence of polymer for the enhancement of overall physicochemical performance.Methods: The process of agglomeration involves the use of dichloromethane (DCM) as a good solvent and chloroform as bridging liquid were used to prepare agglomerates. Agglomerates were characterised in the solid state using several techniques such as Scanning electronic microscopy(SEM), Fourier transformation infrared spectroscopy (FTIR), X-ray powder diffraction analysis (XRPD) The agglomerates obtained were evaluated for micrometric, mechanical, deformation, compressibility and drug release properties.Results: It was found that micrometric properties and dissolution characteristics of agglomerates were significantly improved than that of pure linezolid. Solubility was found to be increased than pure linezolid. The solubility of crystallo co-agglomerates was found an increase in 5 fold 3 fold and 3.7 fold for PVPK30 (0.5%), PVPK30 (0.25%) and PVPK30 (0.75%) respectively. The angle of repose for all batches was found between 22 ° to 30 °Carrs index was between 12.27±0.6 to 18.73±0.4 and Hausners ratio Near to 1, indicated good flow ability of agglomerates. The time required for drug release over a period of 60 min, is as LA1>LA2>LA3. LA3 shows fast drug release than LA1 and LA2, due to solubilization of drug due to more concentration of PVPK30 and less concentration of talc.Conclusion: Based on the above results, it was revealed that CCA of linezolid prepared with DCM and HPMC (Hydroxypropyl methyl cellulose)/PEG (Polyethylene glycol)/PVP (Polyvinylpyrrolidone) K30 exhibited improved micrometric properties, compressibility and in addition to improving solubility and dissolution rate.

scholarly journals Engineering Properties of Peeled and Unpeeled Multiplier Onion

2020 ◽  
Vol 8 (3) ◽  
pp. 232-238
Author(s):  
Dawn C.P. Ambrose
Keyword(s):  
Mechanical Properties ◽  
Physical Properties ◽  
Coefficient Of Friction ◽  
Angle Of Repose ◽  
Engineering Properties ◽  
True Density ◽  
Crushing Strength ◽  
Frictional Properties ◽  
Allium Cepa L ◽  
Multiplier Onion

Multiplier onion (Allium cepa L. var aggregatum. Don.) is mainly used for its unique flavour in seasoning dishes. The unpeeled onions are processed at farm level by means of primary processing and by secondary processing various products like paste, flakes, powder could be produced from peeled onions. For the design of processing and handling equipment knowledge of engineering properties is essential. The engineering properties of peeled and unpeeled multiplier onion were determined. The average values of the physical properties of unpeeled onion were recorded for bulk density and true density as 636.621 and 1526.825 kg/m3 respectively. Similarly for peeled onions, the bulk and true density were 627.03 and 1108.74 kg/m3 respectively. The moisture present in peeled and unpeeled onion was 77.66 % and 74.43% (w.b) respectively. The TSS of multiplier onion was found to be 20° Brix for both peeled and unpeeled samples. The colour values were also measured using colour flex meter for the peeled and unpeeled onions. The frictional properties including coefficient of friction, filling and emptying angle of repose were also measured. Mechanical properties were determined by using a texture analyser. The firmness was measured in terms of penetrating force and crushing strength which were recorded to be 8.59 N and 124.93 N respectively for peeled and 12.00 N and 138.35 N respectively for unpeeled onions.

Formulation and Evaluation of Immediate Release Tablets of Etizolam

2021 ◽  
pp. 281-284
Author(s):  
Abhishek Kumar Singh ◽  
Kasif Shakeel
Keyword(s):  
Immediate Release ◽  
Magnesium Stearate ◽  
Angle Of Repose ◽  
In Vitro Dissolution ◽  
Wet Granulation ◽  
Dissolution Profile ◽  
Compressibility Index ◽  
Tablet Hardness ◽  
In Vitro Disintegration

In the present investigation, immediate release tablet formulation of etizolam was developed for management of insomnia and anxiety using different Superdisintegrants (Sodium Starch Glycolate, Croscarmellose, Crospovidone), Povidone K-30 and Magnesium stearate by wet granulation method. The drug-excipients interaction was investigated by UV spectrophotometer. The granules and tablets of Etizolam were evaluated for various pre and post compression parameters like angle of repose, compressibility index, hausners ratio, tablet hardness, friability and in vitro disintegration and dissolution studies and their results were found to be satisfactory. These results suggest that maximum in vitro dissolution profile of formulation F6 were found to have equivalent percentage of drug release and concluded that F6 is better and similar to innovator product.

Sign in / Sign up

Export Citation Format

Share Document