Aim: Telfairia occidentalis has been reported to possess numerous health benefits. This study assessed the histomorphological effect of aqueous leaf extract of Tefairia occidentalis on the liver architecture of wistar rats.
Methodology: Sixteen adult female rats weighing between 140-240g were divided into four groups (I-IV) comprising of four (4) rats each. Group I, the control, was given normal rat feed with water, while group II, III, and IV were administered with 150mg/kg, 300mg/kg and 600mg/kg body weight of aqueous leaf extract of Telfairia occidentalis orally respectively via intubation method for 28 days. Thereafter, the experimental animals were sacrificed and their respective liver harvested for histomorphological examination using haematoxylin and eosin (H and E) standard laboratory method.
Results: Results showed that there was a significant decrease in the relative weight of the liver in groups II-IV when compared to group I respectively (p<0.05). Photomicrographic section of the liver showed normal hepatic tissue architecture with central vain (CV), portal triad (PT) and hepatocyte (H) in the control animals while photomicrograph section of the liver administered with 150mg/kg aqueous extract of Telfairia occidentalis showed hepatic tissue with focal aggregate inflammatory cell (FAIC) and normal tissue architecture with portal triad (PT) but photomicrograph of liver administered with 300mg/kg and 600mg/kg aqueous extract of Telfairia occidentalis showed alterations.
Conclusion: This study revealed that the aqueous leaf extracts of Telfairia occidentalis may possess hepatoprotective effects although it may enhance some physiological changes such as mild hemolysis, infiltration of some inflammatory cells and intra-hepatic hemorrhage detected in this study.
Key Words: liver, histomorphology, Telfairia occidentalis, weight, hepatoprotective effect.