scholarly journals Physicochemical characterisation of spray dried ternary solid dispersions of simvastatin. Processability, tableting and dissolution.

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Anant Paradkar ◽  
Hanan Abdalmaula ◽  
Krzysztof J Paluch
Keyword(s):  
Solid Dispersions ◽  
Ternary Solid Dispersions ◽  
Physicochemical Characterisation ◽  
Spray Dried

scholarly journals Design of spray dried ternary solid dispersions comprising itraconazole, soluplus and HPMCP: Effect of constituent compositions

2017 ◽  
Vol 519 (1-2) ◽  
pp. 365-372 ◽  
Author(s):  
Mark T. Davis ◽  
Catherine B. Potter ◽  
Maryam Mohammadpour ◽  
Ahmad B. Albadarin ◽  
Gavin M. Walker
Keyword(s):  
Solid Dispersions ◽  
Ternary Solid Dispersions ◽  
Spray Dried

Anomalous properties of spray dried solid dispersions

2009 ◽  
Vol 98 (12) ◽  
pp. 4724-4737 ◽  
Author(s):  
Hisham Al-Obaidi ◽  
Steve Brocchini ◽  
Graham Buckton
Keyword(s):  
Solid Dispersions ◽  
Spray Dried

Spray-dried solid dispersions containing ferulic acid: comparative analysis of three carriers, in vitro dissolution, antioxidant potential and in vivo anti-platelet effect

2016 ◽  
Vol 42 (11) ◽  
pp. 1813-1824 ◽  
Author(s):  
Jessica Mendes Nadal ◽  
Mona Lisa Simionatto Gomes ◽  
Débora Maria Borsato ◽  
Martinha Antunes Almeida ◽  
Fernanda Malaquias Barboza ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Ferulic Acid ◽  
Solid Dispersions ◽  
Antioxidant Potential ◽  
In Vitro Dissolution ◽  
Spray Dried

scholarly journals Spray-Dried Amorphous Solid Dispersions of Griseofulvin in HPC/Soluplus/SDS: Elucidating the Multifaceted Impact of SDS as a Minor Component

Pharmaceutics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 197 ◽  
Author(s):  
Mahbubur Rahman ◽  
Stephanie Ahmad ◽  
James Tarabokija ◽  
Nathaniel Parker ◽  
Ecevit Bilgili
Keyword(s):  
Solid Dispersions ◽  
Sodium Dodecyl ◽  
Minor Component ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersions ◽  
Acetone Water ◽  
Poorly Soluble ◽  
A Minor ◽  
The Impact ◽  
Spray Dried

This study aimed to elucidate the impact of a common anionic surfactant, sodium dodecyl sulfate (SDS), along with hydroxypropyl cellulose (HPC) and Soluplus (Sol) on the release of griseofulvin (GF), a poorly soluble drug, from amorphous solid dispersions (ASDs). Solutions of 2.5% GF and 2.5%–12.5% HPC/Sol with 0.125% SDS/without SDS were prepared in acetone–water and spray-dried. The solid-state characterization of the ASDs suggests that GF–Sol had better miscibility and stronger interactions than GF–HPC and formed XRPD-amorphous GF, whereas HPC-based ASDs, especially the ones with a lower HPC loading, had crystalline GF. The dissolution tests show that without SDS, ASDs provided limited GF supersaturation (max. 250%) due to poor wettability of Sol-based ASDs and extensive GF recrystallization in HPC-based ASDs (max. 50%). Sol-based ASDs with SDS exhibited a dramatic increase in supersaturation (max. 570%), especially at a higher Sol loading, whereas HPC-based ASDs with SDS did not. SDS did not interfere with Sol’s ability to inhibit GF recrystallization, as confirmed by the precipitation from the supersaturated state and PLM imaging. The favorable use of SDS in a ternary ASD was attributed to both the wettability enhancement and its inability to promote GF recrystallization when used as a minor component along with Sol.

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