Cancer remains the dominant disease target for biotech through to 2010

Fleur Pijpers; Mark J Belsey

doi:10.5912/jcb179

Cancer remains the dominant disease target for biotech through to 2010

Journal of Commercial Biotechnology ◽

10.5912/jcb179 ◽

1969 ◽

Vol 12 (4) ◽

Author(s):

Fleur Pijpers ◽

Mark J Belsey

Keyword(s):

Recombinant Proteins ◽

Inflammatory Disorder ◽

Biological Products ◽

Market Growth ◽

Pharmaceutical Markets ◽

Dominant Disease ◽

Will Power ◽

Reported Data ◽

Strategic Market ◽

Biological Market

The two leading therapeutic areas for biological products, in terms of current sales and pipeline focus, are oncology and AIID (arthritis, immune and inflammatory disorders). Datamonitor's biotechnology strategic market analysis team recently analysed the AIID market, since this sector is currently powering biotechnology market growth, owing to high demand for biologicals to treat rheumatoid arthritis and psoriasis (Belsey, M. and Churchill, C. (2006) 'Autoimmune and inflammatory disorder biologicals will power biotech market growth through to 2010', J. Comm. Biotechnol., Vol. 12, No. 2, pp. 237â€“241). In the current paper, we have analysed the oncology market, since biologicals designed to treat cancer indications have underpinned the development of the biotechnology market since its inception in the 1980s. Biological products treat a wide variety of cancers, of which the most prevalent are the 'big four' tumour types â€“ breast cancer, lung cancer, prostate cancer and colorectal cancer. In terms of technology focus, both monoclonal antibody therapeutics and recombinant proteins are set to drive cancer biological market growth. Key growth drivers include mainly Genentech and Roche products, such as Avastin (bevacizumab), Rituxan (rituximab) and Herceptin (trastuzumab), as well as Amgen products, including the second-generation recombinant proteins Neulasta (pegfilgrastim) and Aranesp (darbepoetin alfa). Across the major pharmaceutical markets, oncology biologicals generated US$10.7bn in 2004 (based on company-reported data), which Datamonitor forecasts to rise to US$29.0bn by 2010.

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Autoimmune and inflammatory disorder biologicals will power biotech market growth through to 2010

Journal of Commercial Biotechnology ◽

10.5912/jcb172 ◽

2006 ◽

Vol 12 (3) ◽

Author(s):

Clare A C Churchill ◽

Mark J Belsey

Keyword(s):

Market Analysis ◽

Inflammatory Disorder ◽

Annual Growth Rate ◽

Market Growth ◽

Compound Annual Growth Rate ◽

Antibody Therapeutics ◽

Wide Range ◽

Will Power ◽

Strategic Market ◽

Biological Market

Biologicals designed to treat arthritis, immune and inflammatory disorders (AIID) are currently powering biotechnology market growth. Datamonitor's biotechnology strategic market analysis team has therefore analysed this market to identify key biological products, together with growth drivers and resistors shaping the growth of this market. The AIID market covers a wide range of indications; however, the most prevalent are rheumatoid arthritis and psoriasis, which together represent a significant healthcare burden. A range of monoclonal antibody therapeutics such as Abbott/CAT's Humira are set to drive AIID biological market growth, together with Amgen/Wyeth's fusion protein Enbrel. Owing to very strong sales of Enbrel as a result of continued label expansion, Amgen is set to record the greatest biological AIID sales from 2004 to 2010. Many of the highly efficacious AIID biologicals such as Enbrel target TNF, which is rapidly emerging as the leading cytokine target for many AIID indications. Overall, AIID biologicals generated US$5.4bn in 2004, and this is set to rise to US$14.3bn by 2010: a strong compound annual growth rate of 17.9 per cent.

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Autoimmune and inflammatory disorder biologicals will power biotech market growth through to 2010

Journal of Commercial Biotechnology ◽

10.1057/palgrave.jcb.3040172 ◽

2006 ◽

Vol 12 (3) ◽

pp. 237-241 ◽

Cited By ~ 1

Author(s):

Clare A C Churchill ◽

Mark J Belsey

Keyword(s):

Inflammatory Disorder ◽

Market Growth ◽

Will Power

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Strategic Market Growth and Policy Recommendations for Sustainable Solar Energy Deployment in South Korea

Journal of Electrical Engineering and Technology ◽

10.1007/s42835-019-00331-6 ◽

2019 ◽

Vol 15 (2) ◽

pp. 803-815 ◽

Cited By ~ 8

Author(s):

Mohammed H. Alsharif ◽

Khalid Yahya ◽

Zong Woo Geem

Keyword(s):

Solar Energy ◽

South Korea ◽

Policy Recommendations ◽

Market Growth ◽

Strategic Market

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Enhancing Spatial Ability Through Sport Practice

Journal of Individual Differences ◽

10.1027/1614-0001/a000075 ◽

2012 ◽

Vol 33 (2) ◽

pp. 83-88 ◽

Cited By ~ 58

Author(s):

David Moreau ◽

Jérome Clerc ◽

Annie Mansy-Dannay ◽

Alain Guerrien

Keyword(s):

Mental Rotation ◽

Spatial Representations ◽

Mental Rotation Test ◽

Sport Training ◽

Sport Practice ◽

Undergraduate University Students ◽

Before And After ◽

Cognitive Plasticity ◽

Reported Data ◽

The Relationship

This experiment investigated the relationship between mental rotation and sport training. Undergraduate university students (n = 62) completed the Mental Rotation Test ( Vandenberg & Kuse, 1978 ), before and after a 10-month training in two different sports, which either involved extensive mental rotation ability (wrestling group) or did not (running group). Both groups showed comparable results in the pretest, but the wrestling group outperformed the running group in the posttest. As expected from previous studies, males outperformed women in the pretest and the posttest. Besides, self-reported data gathered after both sessions indicated an increase in adaptive strategies following training in wrestling, but not subsequent to training in running. These findings demonstrate the significant effect of training in particular sports on mental rotation performance, thus showing consistency with the notion of cognitive plasticity induced from motor training involving manipulation of spatial representations. They are discussed within an embodied cognition framework.

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Relative Importance of Leader Influences for Subordinates’ Proactive Behaviors, Prosocial Behaviors, and Task Performance

Journal of Personnel Psychology ◽

10.1027/1866-5888/a000105 ◽

2014 ◽

Vol 13 (2) ◽

pp. 70-86 ◽

Cited By ~ 30

Author(s):

Dan S. Chiaburu ◽

Troy A. Smith ◽

Jiexin Wang ◽

Ryan D. Zimmerman

Keyword(s):

Task Performance ◽

Transformational Change ◽

Future Research ◽

Contingent Reward ◽

Work Effectiveness ◽

Leader Influence ◽

Member Exchange ◽

Proactive Behaviors ◽

Reported Data ◽

Transactional Leader

We meta-analytically examine the relationships between three forms of leader influence, contingent reward (transactional), leader-member exchange (LMX; relational), and transformational (change-oriented) on subordinates’ proactive behaviors. Using non-self-reported data from a combined sample of more than 9,000 employees, we confirm positive relationships between leader influences and employee proactive outcomes. We examine the extent to which one leadership influence is stronger than the others in promoting subordinate proactivity. By combining our new meta-analytic data with existing meta-analytic correlations, we further investigate the extent to which various leadership predictors are differentially related to proactive and prosocial contextual performance, and to task performance. For all outcomes, there are only minimal differences between the contingent reward, LMX, and transformational leadership predictors. Using our results, we propose future research directions for the relationship between leader influences and subordinate work effectiveness.

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