scholarly journals Bioactive compounds and antimicrobial potential of the roots extract of Anogeissus leiocarpa, a chewing stick used for oral care in Benin Republic

2020 ◽  
Vol 12 (4) ◽  
pp. 71-80
Author(s):  
Théophile Olayé ◽  
Fidèle Paul Tchobo ◽  
Nicodème Chabi ◽  
Hornel Koudokpon ◽  
Abou Madjid Olatoundé Amoussa ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Oral Care ◽  
Antimicrobial Potential ◽  
Benin Republic

scholarly journals Lilium Philadelphicum Flower as a Novel Source of Antimicrobial Agents: A Study of Bioactivity, Phytochemical Analysis and Partial Identification of Antimicrobial Metabolites

2021 ◽  
Author(s):  
Shefali Singh ◽  
Vineeta Singh ◽  
Alaa Alhazami ◽  
B.N. Mishra ◽  
Shafiul Haque ◽  
...  
Keyword(s):  
Cell Viability ◽  
Bioactive Compounds ◽  
Bioactive Compound ◽  
Biologically Active ◽  
Gas Chromatography Mass Spectrometry ◽  
Achromobacter Xylosoxidans ◽  
Phytochemical Analysis ◽  
Antimicrobial Potential ◽  
Compound Concentration

The members of the Liliaceae family have been regarded as an excellent source of biologically active compounds. However, the work on antimicrobial potential and characterization of the bioactive fractions of Lilium philadelphicum flower is limited and needs to be explored. The present study reports the antimicrobial potential, anti-inflammatory and anticancer potential of the bioactive fraction extracted from the flower of L. philadelphicum (Red Lily) and characterization of these bioactive compounds. The antimicrobial activity was tested against nine different Gram-positive and Gram-negative bacterial strains. The minimum inhibitory concentration (MIC) values of methanolic extract of L. philadelphicum flower against Acinetobacter bouvetii, Achromobacter xylosoxidans, Bacillus subtilis MTCC 121, Candida albicans MTCC 183, Klebsiella pneumoniae MTCC 3384, and Salmonella typhi MTCC 537 were 25, 50, 12.5, 50, 100 and 50 μg mL-1, respectively. The phytochemical analysis of the extract reveals the presence of phenols, flavonoids, tannins, terpenoids, glycosides, coumarins, and quinones. The cytotoxicity of the partially purified compound against the HepG2 cell line in MTT assay demonstrates up to 90% cell viability with a bioactive compound concentration of 50 μg/ml. However, with the increase in bioactive compound concentration up to 1000 μg/ml results into nearly 80% cell viability, just a minor decline in cell viability suggests the importance of bioactive compounds for suitable therapeutic applications. Spectroscopic studies of the bioactive compound by UV-Visible spectroscopy, FT-Infra Red spectroscopy, Gas Chromatography-Mass Spectrometry (GCMS) as well as its phytochemical analysis suggests the presence of terpenoids moiety, responsible for the antimicrobial property of L. philadelphicum flower.

scholarly journals Research Advances in the Use of Bioactive Compounds from Vitis vinifera By-Products in Oral Care

Antioxidants ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 502
Author(s):  
Cătălina Bogdan ◽  
Anca Pop ◽  
Sonia M. Iurian ◽  
Daniela Benedec ◽  
Mirela L. Moldovan
Keyword(s):  
Oral Health ◽  
Vitis Vinifera ◽  
Bioactive Compounds ◽  
Pathogenic Bacteria ◽  
Oral Care ◽  
Beneficial Effects ◽  
Raising Awareness ◽  
Oral Conditions ◽  
By Products

Oral health is considered an important factor of general health and it contributes to the quality of life. Despite the raising awareness of preventive measures, the prevalence of oral health conditions continues to increase. In this context, a growing interest in investigating natural resources like Vitis vinifera (V. vinifera) phenolic compounds (PhCs) as oral health promoters has emerged. This paper aims to review the evidence about the bioactivities of V. vinifera by-products in oral health. Up to date, a high number of studies have thoroughly reported the antimicrobial and antiplaque activity of V. vinifera extracts against S. mutans or in multi-species biofilms. Moreover, the bioactive compounds from V. vinifera by-products have been shown to modulate the periodontal inflammatory response and the underlying oxidative stress imbalance induced by the pathogenic bacteria. Considering these beneficial effects, the utility of V. vinifera by-products in the maintaining of oral health and the necessary steps towards the development of oral care products were emphasized. In conclusion, the high potential of V. vinifera by-products could be valorized in the development of oral hygiene products with multi-target actions in the prevention and progression of several oral conditions.

scholarly journals Drought Exposed Burkholderia seminalis JRBHU6 Exhibits Antimicrobial Potential Through Pyrazine-1,4-Dione Derivatives Targeting Multiple Bacterial and Fungal Proteins

2021 ◽  
Vol 12 ◽  
Author(s):  
Jay Kishor Prasad ◽  
Priyanka Pandey ◽  
Richa Anand ◽  
Richa Raghuwanshi
Keyword(s):  
Bioactive Compounds ◽  
In Silico ◽  
High Performance ◽  
Hydrolytic Enzymes ◽  
Trichophyton Mentagrophytes ◽  
Docking Studies ◽  
Bioactive Metabolites ◽  
Rrna Gene ◽  
Microsporum Gypseum ◽  
Antimicrobial Potential

The present study aimed to explore the antimicrobial potentials of soil bacteria and identify the bioactive compounds and their likely targets through in silico studies. A total 53 bacterial isolates were screened for their antimicrobial potential of which the strain JRBHU6 showing highest antimicrobial activity was identified as Burkholderia seminalis (GenBank accession no. MK500868) based on 16S ribosomal RNA (rRNA) gene sequencing and phylogenetic analysis. B. seminalis JRBHU6 also produced hydrolytic enzymes chitinases and cellulase of significance in accrediting its antimicrobial nature. The bioactive metabolites produced by the isolate were extracted in different organic solvents among which methanolic extract showed best growth-suppressing activities toward multidrug resistant Staphylococcus aureus and fungal strains, viz Fusarium oxysporum, Aspergillus niger, Microsporum gypseum, Trichophyton mentagrophytes, and Trichoderma harzianum. The antimicrobial compounds were purified using silica gel thin layer chromatography and high-performance liquid chromatography (HPLC). On the basis of spectroscopic analysis, the bioactive metabolites were identified as pyrrolo(1,2-a)pyrazine-1,4-dione,hexahydro (PPDH) and pyrrolo(1,2-a)pyrazine-1,4-dione, hexahydro-3(2-methylpropyl) (PPDHMP). In silico molecular docking studies showed the bioactive compounds targeting fungal and bacterial proteins, among which PPDHMP was multitargeting in nature as reported for the first time through this study.

scholarly journals Antimicrobial Potential of Sonneratia alba and Sonneratia caseolaris against Shrimp Pathogens

2021 ◽  
pp. 7-14
Author(s):  
Dian Yuni Pratiwi
Keyword(s):  
Bioactive Compounds ◽  
Antimicrobial Agents ◽  
Shrimp Farming ◽  
Microbial Pathogens ◽  
Economic Losses ◽  
Negative Effects ◽  
Antimicrobial Potential ◽  
Sonneratia Caseolaris ◽  
Sonneratia Alba

Disease is one of the obstacles in shrimp farming. Many countries have experienced economic losses due to disease in shrimp caused by microbes. Many strategies are being used to overcome the problem such as antibiotics, formalin, probiotics, prebiotics, synbiotics, and others. However, the use antibiotics in long term can cause negative effects. So that, the development of potential new natural compounds is required to overcome this problem. This review article aims to explain the nutritional content, bioactive compounds, antimicrobial potential, and the effect of S. alba and S. caseolaris on shrimp survival. Sonneratia alba and Sonneratia caseolaris are plants that have many bioactive compounds such as alkaloids, flavonoids, terpenoids, and phenolics. They have also been shown to inhibit the growth of bacteria such as Vibrio harveyi, Escherichia coli, Staphylococcus aureus, Saprolegnia sp., and others. Application of S. alba and S. caseolaris can also increase the survival rate of infected shrimps. S. alba and S. caseolaris have the potential to be used as antimicrobial agents and can be used to protect shrimp from microbial pathogens.

scholarly journals ANTIMICROBIAL POTENTIAL AND CHEMICAL AND BIOACTIVE COMPOUNDS IN AGROINDUSTRIAL BY-PRODUCTS FROM PEACH/ POTENCIAL ANTIMICROBIANO E COMPOSTOS QUÍMICOS E BIOATIVOS EM SUBPRODUTOS AGROINDUSTRIAIS DE PÊSSEGO

2021 ◽  
Vol 7 (2) ◽  
pp. 18221-18234
Author(s):  
Cristina Soares Gettens ◽  
Thauana Heberle ◽  
Nádia Carbonera ◽  
Eliezer Avila Gandra ◽  
Márcia Arocha Gularte
Keyword(s):  
Bioactive Compounds ◽  
Antimicrobial Potential ◽  
By Products

scholarly journals Natural bioactive compounds and antimicrobial potential of Pavetta indica L.

2021 ◽  
Vol 10 (4) ◽  
pp. 161-164
Author(s):  
Gobalakrishnan R ◽  
Bhuvaneswari R
Keyword(s):  
Antimicrobial Activity ◽  
Bioactive Compounds ◽  
Antimicrobial Agents ◽  
Soluble Sugars ◽  
Pharmaceutical Research ◽  
Ethanolic Extract ◽  
Soluble Starch ◽  
Terrestrial Plants ◽  
Antimicrobial Potential ◽  
Wide Range

Terrestrial plants have opened up a new perspective for pharmaceutical research and development of novel antimicrobial agents for the treatment of microbial diseases. Therefore, it is necessary to start an urgent need to screen the plants for novel bioactive compounds. In this context, present study was carried out to screen phytochemical constituents from leaves of Pavetta indica L., and its antimicrobial potential. P. indica leaves possess Chlorophyll a (1.21 ±0.05 mg g-1), Chlorophyll b (1.61 ±0.09 mg g-1), total chlorophyll (2.82 ±0.13 mg g-1), carotenoids (0.57 ±0.06 mg g-1), total soluble sugars (30.08 ±0.79 mg g-1), total soluble starch (13.54 ± 0.72), total soluble proteins (47.81 ± 2.82 mg g-1), total free amino acids (5.77 ± 0.69 mg g-1), total phenol (7.67 ± 0.72 mg g-1), hydroxyl phenols (5.74 ± 0.29 mg g-1) and lipids (53.53 ± 2.50 mg g-1) while alkaloids, tannins, steroids, phenolic compounds, saponins, triterpenoids and cardiac glycosides were also present in the leaves of P. indica. Absolute ethanolic extract of P. indica showed significant antimicrobial activity against all the tested pathogens, followed by aqueous extract. In concluded that, P. indica leaves crude extracts have wide range of bioactive compounds and which might be led to potential antimicrobial activity. They may lend to developing novel therapeutic agent to different infectious diseases.

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