scholarly journals Systematic review: Medicinal use and scientific elucidation of the Piper genus for the treatment of symptoms and inflammatory diseases

2020 ◽  
Vol 14 (2) ◽  
pp. 62-72 ◽  
Author(s):  
Norma Fernandes Lima Cícera ◽  
Ferreira de Lima Luciene ◽  
Bezerra Correia Denise ◽  
Tavares de Sousa Machado Sara ◽  
Pereira de Sousa Jéssica ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Diseases ◽  
Medicinal Use

scholarly journals Intelligent medical systems in diagnosing and treating inflammatory diseases of the pancreas (systematic review)

2018 ◽  
Vol 39 (1) ◽  
pp. 10-15
Author(s):  
A. A. Litvin
Keyword(s):  
Systematic Review ◽  
Neural Networks ◽  
Artificial Neural Networks ◽  
Decision Support ◽  
Decision Support Systems ◽  
Support Systems ◽  
Inflammatory Diseases ◽  
Review Of The Literature ◽  
Medical Systems ◽  
Pancreatic Diseases

This paper is a systematic review of the literature on the use of intelligent medical systems in the diagnosis and treatment of acute inflammatory pancreatic diseases. The author provides modern literature data on the efficacy of decision support systems based on artificial neural networks to determine the severity, diagnosis and outcome prognosis of pancreatitis and complications.

scholarly journals Immunogenicity of Biologics in Chronic Inflammatory Diseases: A Systematic Review

BioDrugs ◽  
2017 ◽  
Vol 31 (4) ◽  
pp. 299-316 ◽  
Author(s):  
Vibeke Strand ◽  
Alejandro Balsa ◽  
Jamal Al-Saleh ◽  
Leonor Barile-Fabris ◽  
Takahiko Horiuchi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Diseases ◽  
Chronic Inflammatory Diseases

scholarly journals Biosimilars for the Treatment of Chronic Inflammatory Diseases: A Systematic Review of Published Evidence

BioDrugs ◽  
2016 ◽  
Vol 30 (6) ◽  
pp. 525-570 ◽  
Author(s):  
Ira Jacobs ◽  
Danielle Petersel ◽  
Leah Isakov ◽  
Sadiq Lula ◽  
K. Lea Sewell
Keyword(s):  
Systematic Review ◽  
Inflammatory Diseases ◽  
Chronic Inflammatory Diseases ◽  
Published Evidence

scholarly journals The influence of biologics on the microbiome in immune-mediated inflammatory diseases: A systematic review

2021 ◽  
Vol 141 ◽  
pp. 111904
Author(s):  
Jakub Ruszkowski ◽  
Agnieszka Daca ◽  
Adrian Szewczyk ◽  
Alicja Dębska-Ślizień ◽  
Jacek M. Witkowski
Keyword(s):  
Systematic Review ◽  
Inflammatory Diseases ◽  
Immune Mediated

scholarly journals Outcome selection for tissue-agnostic drug trials for immune-mediated inflammatory diseases: a systematic review of core outcome sets and regulatory guidance

Trials ◽  
2022 ◽  
Vol 23 (1) ◽  
Author(s):  
Olalekan Lee Aiyegbusi ◽  
Lavinia Ferrante di Ruffano ◽  
Ameeta Retzer ◽  
Philip N. Newsome ◽  
Christopher D. Buckley ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Diseases ◽  
Core Outcome ◽  
Core Outcome Sets ◽  
Regulatory Guidance ◽  
Immune Mediated ◽  
Outcome Selection ◽  
Similarities And Differences ◽  
Selection For

Abstract Background Tissue-agnostic drug development provides a paradigm shift in precision medicine and requires innovative trial designs. However, outcome selection for such trials can prove challenging. The objectives of this review were to: Identify and map core outcome sets (COS), across 11 immune-mediated inflammatory diseases (IMIDs) in order to facilitate the selection of relevant outcomes across the conditions for innovative trials of tissue-agnostic drug therapies. Compare outcomes or endpoints recommended by the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) to identify and highlight similarities and differences. Methods The Core Outcome Measures in Effectiveness Trials (COMET), International Consortium for Health Outcomes Measurement (ICHOM), FDA and EMA databases were searched from inception to 28th December 2019. Two reviewers independently screened titles and abstracts of retrieved entries and conducted the subsequent full text screening. Hand searching of the reference lists and citation searching of the selected publications was conducted. The methodological quality of the included peer-reviewed articles was independently assessed by the reviewers based on the items of the COS–Standards for Development recommendations (COS–STAD) checklist. Core outcomes from the included publications were extracted and mapped across studies and conditions. Regulatory guidance from FDA and EMA, where available for clinical trials for the IMIDs, were obtained from their databases and recommendations on outcomes to measure directly compared. Results Forty-four COS publications were included in the final analysis. Outcomes such as disease activity, pain, fatigue, quality of life, physical function, work limitation/productivity, steroid use and biomarkers were recommended across majority of the conditions. There were significant similarities and differences in FDA and EMA recommendations. The only instance where either regulatory body directly referenced a COS was for jSLE—both referenced the Paediatric Rheumatology International Trials Organization (PRINTO) COS. Conclusions The findings from this systematic review provide valuable information to inform outcome selection in tissue-agnostic trials for IMIDs. There is a need for increased collaboration between regulators and COS developers and inclusion of regulators as key stakeholders in COS development to enhance the quality of COS. Trial registration Not registered.

scholarly journals COVID-19 AND PATIENTS UNDERGOING PHARMACOLOGICAL TREATMENTS FOR IMMUNE-MEDIATED INFLAMMATORY DISEASES: PROTOCOL FOR A RAPID LIVING SYSTEMATIC REVIEW

2020 ◽  
Author(s):  
Maria Eduarda dos Santos Puga ◽  
Aline Pereira da Rocha ◽  
Alvaro Nagib Atallah ◽  
Ana Carolina Pereira Nunes Pinto ◽  
César Ramos Rocha-Filho ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Diseases ◽  
Pharmacological Treatments ◽  
Immune Mediated

scholarly journals Allium sativum L. (Garlic) Role in Osteoarthritis: A Systematic Review of Clinical Trials

2021 ◽  
Vol 11 (4) ◽  
pp. 12104-12119
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Side Effects ◽  
Allium Sativum ◽  
Inflammatory Diseases ◽  
Control Group ◽  
Therapeutic Effects ◽  
Inflammatory Factor ◽  
Anti Inflammatory ◽  
Over Time

Osteoarthritis is a chronic degenerative disease involving the joints and bones, causing their degradation over time. Inflammation, pain, and stiffness in joints are indicators of the disease. Pharmacotherapy cannot always be efficient and may cause side effects. So, adjuncts such as complementary herbs have become of note. Garlic is a herb well-known for its various therapeutic effects such as anti-bacterial, anti-hypertension, antioxidant and anti-inflammatory effects. Due to garlic's widespread use, studying its effects and mechanisms on inflammatory diseases such as osteoarthritis has been noteworthy. We searched Science Direct, Pubmed, Cochrane, and Google Scholar databases for all articles published until October 2020, based on PRISMA. Searched keywords were the following: [(garlic and arthritis), (garlic and osteoarthritis), (Garlic and OA), (Allium sativum and arthritis), (Allium sativum and osteoarthritis), (Allium sativum and OA)]. The results showed garlic, and its constituents have remarkable effects on improving OA symptoms through antioxidant and anti-inflammatory pathways. Our review shows that groups receiving garlic as a treatment showed a significant reduction in pain and inflammatory factor levels and an improved physical function instead of the control group.

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