scholarly journals Anti-proliferative and cytotoxic effects of methanol extract of the leaves of Momordica charantia L. (Cucurbitaceae) on vascular smooth muscle cells (VSMC) and HT-29 cell lines

2017 ◽  
Vol 11 (42) ◽  
pp. 665-672
Author(s):  
S. O. Ofuegbe ◽  
A. A. Oyagbemi ◽  
T. O. Omobowale ◽  
O. S. Fagbohun ◽  
M. A. Yakubu ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Cell Lines ◽  
Vascular Smooth Muscle Cells ◽  
Methanol Extract ◽  
Muscle Cells ◽  
Momordica Charantia ◽  
Cytotoxic Effects ◽  
Ht 29

scholarly journals Fetuin-A and Albumin Alter Cytotoxic Effects of Calcium Phosphate Nanoparticles on Human Vascular Smooth Muscle Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e97565 ◽  
Author(s):  
Yana Dautova ◽  
Diana Kozlova ◽  
Jeremy N. Skepper ◽  
Matthias Epple ◽  
Martin D. Bootman ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Calcium Phosphate ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Cytotoxic Effects ◽  
Fetuin A ◽  
Calcium Phosphate Nanoparticles

scholarly journals Orai1 and Ca2+-independent phospholipase A2 are required for store-operated Icat-SOC current, Ca2+ entry, and proliferation of primary vascular smooth muscle cells

2012 ◽  
Vol 302 (5) ◽  
pp. C748-C756 ◽  
Author(s):  
Bo Yang ◽  
Tomasz Gwozdz ◽  
Joanna Dutko-Gwozdz ◽  
Victoria M. Bolotina
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Dna Synthesis ◽  
Phospholipase A2 ◽  
Cell Lines ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Multiple Functions

Store-operated Ca2+ entry (SOCE) is important for multiple functions of vascular smooth muscle cells (SMC), which, depending of their phenotype, can resemble excitable and nonexcitable cells. Similar to nonexcitable cells, Orai1 was found to mediate Ca2+-selective (CRAC-like) current and SOCE in dedifferentiated cultured SMC and smooth muscle-derived cell lines. However, the role of Orai1 in cation-selective store-operated channels (cat-SOC), which are responsible for SOCE in primary SMC, remains unclear. Here we focus on primary SMC, and assess the role of Orai1 and Ca2+-independent phospholipase A2 (iPLA2β, or PLA2G6) in activation of cat-SOC current ( Icat-SOC), SOCE, and SMC proliferation. Using molecular, electrophysiological, imaging, and functional approaches, we demonstrate that molecular knockdown of either Orai1 or iPLA2β leads to similar inhibition of the whole cell cat-SOC current and SOCE in primary aortic SMC and results in significant reduction in DNA synthesis and impairment of SMC proliferation. This is the first demonstration that Orai1 and iPLA2β are equally important for cat-SOC, SOCE, and proliferation of primary aortic SMC.

Docosahexaenoic acid (DHA)-induced heme oxygenase-1 attenuates cytotoxic effects of DHA in vascular smooth muscle cells

2013 ◽  
Vol 230 (2) ◽  
pp. 406-413 ◽  
Author(s):  
Gabriel Stulnig ◽  
Marie-Therese Frisch ◽  
Slaven Crnkovic ◽  
Philipp Stiegler ◽  
Michael Sereinigg ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Docosahexaenoic Acid ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Heme Oxygenase ◽  
Muscle Cells ◽  
Heme Oxygenase 1 ◽  
Cytotoxic Effects

Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells

2003 ◽  
Vol 284 (2) ◽  
pp. L279-L289 ◽  
Author(s):  
Susan J. Smith ◽  
Steven Brookes-Fazakerley ◽  
Louise E. Donnelly ◽  
Peter J. Barnes ◽  
Mary S. Barnette ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
T Cell ◽  
T Lymphocytes ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Cardiac Myocytes ◽  
Cell Lines ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Lung Fibroblasts

We have determined the expression of phosphodiesterase (PDE) 7A1 and PDE7A2 in human cells that have been implicated in the pathogenesis of chronic obstructive pulmonary disease and asthma. Messenger RNA transcripts were detected by RT-PCR in T lymphocytes, monocytes, neutrophils, airway and vascular smooth muscle cells, lung fibroblasts, epithelial cells, and cardiac myocytes. Human epithelial, T cell, eosinophil, and lung fibroblast cell lines were also positive for PDE7A1 and PDE7A2 mRNA transcripts. By Western immunoblot analyses the amount of PDE7A1 was greatest in T cell lines, peripheral blood T lymphocytes, epithelial cell lines, airway and vascular smooth muscle cells, lung fibroblasts, and eosinophils but was not detected in neutrophils. In contrast, PDE7A2 protein, which was identified in human cardiac myocytes, was not found in any of the other cell types investigated. Immunoconfocal analyses showed that PDE7A was expressed in neutrophils and alveolar macrophages. As the expression of PDE7A mirrors the distribution of PDE4 we speculate that this enzyme could be a target for novel anti-inflammatory drugs.

Cytotoxic Effects of Lysophosphatidylcholine on Vascular Smooth Muscle Cells

2012 ◽  
Vol 18 (3) ◽  
pp. 139 ◽  
Author(s):  
Dong-Yun Lee ◽  
Young-Hee Kang ◽  
Doo Seok Choi ◽  
Young Joo Lee ◽  
Mee-Ra Rhyu ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Cytotoxic Effects

scholarly journals Cytotoxic effects of a recombinant chimeric toxin on rapidly proliferating vascular smooth muscle cells.

Circulation ◽  
1991 ◽  
Vol 84 (2) ◽  
pp. 778-787 ◽  
Author(s):  
S E Epstein ◽  
C B Siegall ◽  
S Biro ◽  
Y M Fu ◽  
D FitzGerald ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Cytotoxic Effects
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