scholarly journals Levels of prostaglandin E2 (PGE2) in gingival crevicular fluid from smokers and non-smokers with gingivitis and chronic periodontal disease

2015 ◽  
Vol 7 (5) ◽  
pp. 54-59 ◽  
Author(s):  
Alessandra da Cruz Galhardo Camargo Gabriela ◽  
Pereira dos Santos Marcelo ◽  
Linhares Coutinho Silva Natalia ◽  
Luisa Palhares de Miranda Ana ◽  
Luiz Mendonca Tributino Jorge
Keyword(s):  
Periodontal Disease ◽  
Prostaglandin E2 ◽  
Gingival Crevicular Fluid ◽  
Chronic Periodontal Disease ◽  
Crevicular Fluid

RP-HPLC assay of doxycycline in human saliva and gingival crevicular fluid in patients with chronic periodontal disease

2013 ◽  
Vol 78-79 ◽  
pp. 170-175 ◽  
Author(s):  
Marko S. Denić ◽  
Slavica M. Sunarić ◽  
Ljiljana G. Kesić ◽  
Ivan Z. Minić ◽  
Radmila R. Obradović ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Gingival Crevicular Fluid ◽  
Human Saliva ◽  
Hplc Assay ◽  
Rp Hplc ◽  
Chronic Periodontal Disease ◽  
Crevicular Fluid

scholarly journals PROSTAGLANDIN LEVELS IN GINGIVAL CREVICULAR FLUID IN PERIODONTITIS PATIENT WITH HYPERTENSION

2020 ◽  
pp. 19-22
Author(s):  
RADITYA PRIHARNANTO ◽  
ROBERT LESSANG ◽  
SRI LELYATI C MASULILI ◽  
FATIMAH MARIA TADJOEDIN ◽  
HERLIS RAHDEWATI ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Periodontal Disease ◽  
Prostaglandin E2 ◽  
Gingival Crevicular Fluid ◽  
Clinical Sample ◽  
Tooth Surface ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Significant Difference ◽  
Crevicular Fluid

Objective: Periodontitis is an infection that involved tooth-supporting tissues by dental plaque biofilm on the tooth surface and host immune responseas causal to as inflammation resolution. Prostaglandin E2 (PGE2) as an inflammatory mediator has been implicated in the pathogenesis of variouschronic inflammatory diseases, including periodontitis, and as a regulator of blood pressure. This study aims to compare the levels of prostaglandinin the gingival crevicular fluid (GCF) of periodontitis patients with hypertension and non-hypertension.Methods: A total sample of 62 patients was examined and consists of 44 patients (aged 50–90 years) who were hypertension group and 18 patients(aged 30–49 years) who were non-hypertension groups as a control. Hypertension state was measured by blood pressure based on anamnesisand using sphygmomanometer mercury. The clinical sample was collected from 62 gingival crevicular fluids [GCF] of periodontal disease subject.Measurement of the clinical parameter of probing pocket depth [PD], and bleeding on probing [BOP ≥1] was included as a diagnostic requisition.The PD and clinical attachment loss [CAL] was defined as present if the PD was ≥5 mm and CAL was ≥1 mm. Prostaglandin E2 level was estimated ingingival crevicular fluid samples by using the enzyme-linked immunosorbent assay.Results: The level of PGE2 was statistically significant difference in hypertension patient compare with non-hypertension (p<0.05). There was asignificant difference in PD, recession, and CAL (p<0.05).Conclusion: Higher blood pressure might be related to the potential risk of inflammation and progression periodontal disease.

scholarly journals A pilot study of active enzyme levels in gingival crevicular fluid of patients with chronic periodontal disease

2016 ◽  
Vol 43 (8) ◽  
pp. 629-636 ◽  
Author(s):  
Sarhang S. Gul ◽  
Charles W. I. Douglas ◽  
Gareth S. Griffiths ◽  
Andrew Rawlinson
Keyword(s):  
Pilot Study ◽  
Periodontal Disease ◽  
Gingival Crevicular Fluid ◽  
Active Enzyme ◽  
Chronic Periodontal Disease ◽  
Crevicular Fluid

Salivary Diagnosis - Clinical Uses in Assessing Oral Inflammation

2017 ◽  
Vol 68 (6) ◽  
pp. 1201-1204 ◽  
Author(s):  
Iulia Ioana Stanescu ◽  
Alexandra Totan ◽  
Florentina Rus ◽  
Daniela Miricescu ◽  
Brandusa Mocanu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Periodontal Disease ◽  
Gingival Crevicular Fluid ◽  
Oxidative Stress Marker ◽  
Clinical Settings ◽  
Tissue Destruction ◽  
Whole Saliva ◽  
Oral Inflammation ◽  
Positive Correlations ◽  
Crevicular Fluid

The past decades demonstrated that saliva and its components represent a remarkable diagnosis fluid with valuable clinical uses for both oral and systemic diseases. At the same time it is well established that oxidative stress is involved in a wide number of pathologies, including periodontitis. The specific aim of the present study which included 50 subjects is to determine if saliva can be used in clinical settings to correlate oxidative stress and tissue destruction markers with the severity of periodontal disease. An important oxidative stress marker - 8-hydroxydesoxyguanosine (8-OHdG) and a collagen degradation marker - beta-crosslaps (b-CTX) were quantified in both saliva and gingival crevicular fluid (GCF) using ELISA kits and were found to be significantly increased in the chronic periodontitis group when compared to respective controls (p[0.05). At the same time positive correlations were observed between whole saliva and gingival crevicular fluid (p[0.05). Significant correlations were also determined between GCF and salivary markers and clinical parameters of periodontal disease. Present results demonstrate that saliva and its components can successfully be used in clinical settings and represents a reliable tool for assessing periodontal disease severity.

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