scholarly journals Vitamin D and Insulin resistance in gestational diabetes mellitus

2017 ◽  
Vol 8 (3) ◽  
pp. 17-25
Author(s):  
M. Gashlan Hana ◽  
F. H. Noureldeen Amani ◽  
A. Elsherif Hanaa ◽  
Tareq Ohood
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus

scholarly journals Maternal Vitamin D Status in Gestational Diabetes Mellitus Women

2021 ◽  
pp. 55-63
Author(s):  
Zainedeen Nassar ◽  
Mazen Alzaharna
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Gaza Strip ◽  
Density Lipoprotein ◽  
Vitamin D Status

Aims: To assess vitamin D status among Gestational Diabetes Mellitus pregnant women in Gaza Strip. Study Design: Case control study. Place and Duration of Study: Samples were collected from pregnant women attending primary health care centers, Gaza, Gaza Strip. Methodology: The study comprised 90 participants, 45 GDM pregnant women and 45 apparently healthy pregnant women. Serum vitamin D and insulin levels were measured by ELISA, fasting blood glucose (FBG), 2 h oral glucose tolerance test (OGTT), glycated hemoglobin (HbA1c), triglycerides (TG), cholesterol, high-density lipoprotein (HDL), phosphorus and calcium were determined chemically. Blood pressure was measured. Body mass index (BMI) and low-density lipoprotein (LDL) were calculated. Ethical approval was acquired from Helsinki committee. All data was analyzed using the SPSS program. Results: The average vitamin D in GDM cases was lower than that in controls (P=0.031). There was an increase in the average of FBG, OGTT, HbA1c and insulin levels in GDM cases versus controls (P<0.001). The average levels of serum cholesterol, TG and LDL were significantly higher in cases as compared to controls. The average systolic and diastolic blood pressure levels were higher in GDM cases in relation to controls. Pearson correlation test showed a significant negative correlation between vitamin D and the parameters: BMI, glucose, OGTT, HbA1c and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). Conclusion: Vitamin D was lower in GDM women compared to controls. Low vitamin D status may be associated with insulin resistance and act as a risk factor for GDM.

scholarly journals Plasma retinol-binding protein 4 in the first and second trimester and risk of gestational diabetes mellitus in Chinese women: a nested case-control study

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Chuyao Jin ◽  
Lizi Lin ◽  
Na Han ◽  
Zhiling Zhao ◽  
Zheng Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Binding Protein ◽  
First Trimester ◽  
Retinol Binding Protein ◽  
Second Trimester ◽  
Retinol Binding Protein 4 ◽  
Plasma Retinol

Abstract Background To assess the association between plasma retinol-binding protein 4 (RBP4) levels both in the first trimester and second trimester and risk of gestational diabetes mellitus (GDM). Methods Plasma RBP4 levels and insulin were measured among 135 GDM cases and 135 controls nested within the Peking University Birth Cohort in Tongzhou. Multivariable linear regression analysis was conducted to assess the influence of RBP4 levels on insulin resistance. Conditional logistic regression models were used to compute the odds ratio (OR) and 95% confidence interval (CI) between RBP4 levels and risk of GDM. Results The GDM cases had significantly higher levels of RBP4 in the first trimester than controls (medians: 18.0 μg/L vs 14.4 μg/L; P < 0.05). Plasma RBP4 concentrations in the first and second trimester were associated with fasting insulin, homeostasis model assessment for insulin resistance (HOMA-IR), and the quantitative insulin sensitivity check index (QUICKI) in the second trimester (all P < 0.001). With adjustment for diet, physical activity, and other risk factors for GDM, the risk of GDM increased with every 1-log μg/L increment of RBP4 levels, and the OR (95% CI) was 3.12 (1.08–9.04) for RBP4 in the first trimester and 3.38 (1.03–11.08) for RBP4 in the second trimester. Conclusions Plasma RBP4 levels both in the first trimester and second trimester were dose-dependently associated with increased risk of GDM.

Gestational diabetes mellitus shares polymorphisms of genes associated with insulin resistance and type 2 diabetes in the Greek population

2010 ◽  
Vol 27 (4) ◽  
pp. 267-272 ◽  
Author(s):  
Kalliopi I. Pappa ◽  
Maria Gazouli ◽  
Konstantinos Economou ◽  
George Daskalakis ◽  
Eleni Anastasiou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Greek Population
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